Alprolix Disease Interactions
There are 2 disease interactions with Alprolix (coagulation factor ix).
Prothrombin complex (applies to Alprolix) heparin-induced thrombocytopenia
Major Potential Hazard, Moderate plausibility.
The brand name products, Kcentra and Bebulin of prothrombin complex, contain heparin; therefore, their use is contraindicated in patients with known heparin-induced thrombocytopenia.
Prothrombin complex (applies to Alprolix) thromboembolism
Major Potential Hazard, Moderate plausibility. Applicable conditions: Coagulation Defect, Thrombotic/Thromboembolic Disorder, Thrombotic Thrombocytopenic Purpura, Myocardial Infarction, Pulmonary Embolism, Disseminated Intravascular Coagulation
The brand name product, Kcentra of prothrombin complex is contraindicated in patients with disseminated intravascular coagulation (DIC). Both fatal and non-fatal arterial thromboembolic events (including acute myocardial infarction and arterial thrombosis), and venous thromboembolic events (including pulmonary embolism and venous thrombosis) and disseminated intravascular coagulation have been reported with the use of this product in clinical trials and post marketing surveillance. Exercise care if using this product in patients with a history of thromboembolic events.
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Alprolix drug interactions
There are 8 drug interactions with Alprolix (coagulation factor ix).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
