Cipaglucosidase alfa Disease Interactions

Patients with an acute underlying illness at the time of avalglucosidase alfa or cipaglucosidase alfa infusion may be at greater risk for infusion-associated reactions (IARs); compromised cardiac and respiratory function may predispose patients to a higher risk of severe complications from IARs. Antihistamines, antipyretics, and/or corticosteroids can be given before avalglucosidase alfa or cipaglucosidase alfa infusion to reduce the risk of IARs; however, IARs may still occur in pretreated patients.

Patients susceptible to fluid volume overload, or patients with acute underlying respiratory illness or compromised cardiac or respiratory function for whom fluid restriction is indicated may be at risk of serious exacerbation of their cardiac or respiratory status during avalglucosidase alfa or cipaglucosidase alfa infusion; more frequent monitoring of vitals should be performed during infusion in such patients. Some patients may require prolonged observation times.