Berotralstat Disease Interactions
There is 1 disease interaction with berotralstat.
Moderate
Berotralstat (applies to berotralstat) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Berotralstat has not been studied in patients with end-stage renal disease (CrCl < 15 mL/min or patients requiring hemodialysis), and its use is not recommended in these patients. No dosage adjustment is recommended for patients with mild, moderate or severe renal impairment.
References (1)
- (2021) "Product Information. Orladeyo (berotralstat)." BioCryst Pharmaceuticals Inc
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Berotralstat drug interactions
There are 524 drug interactions with berotralstat.
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- Drug class: hereditary angioedema agents
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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