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Benzocaine/cetylpyridinium/menthol topical Disease Interactions

There is 1 disease interaction with benzocaine / cetylpyridinium / menthol topical.

Moderate

Benzocaine (applies to benzocaine/cetylpyridinium/menthol topical) methemoglobinemia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency

Rarely, benzocaine has induced methemoglobinemia resulting in respiratory distress and cyanosis. Therapy with benzocaine should be administered cautiously to patients with or predisposed to methemoglobinemia. If life-threatening or severe methemoglobinemia develops, methylene blue infused at a dosage of 1 to 2 mg/kg body weight will rapidly reverse or improve the condition except in G-6-PD-deficient patients.

References

  1. "Product Information. Americaine (benzocaine topical)." Novartis Consumer Health PROD (2001):
  2. "Product Information. Americaine Otic (benzocaine otic)." Medeva Pharmaceuticals PROD (2001):

Benzocaine/cetylpyridinium/menthol topical drug interactions

There are 49 drug interactions with benzocaine / cetylpyridinium / menthol topical.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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