Benznidazole Disease Interactions
There are 4 disease interactions with benznidazole.
Benznidazole (applies to benznidazole) Cockayne syndrome
Major Potential Hazard, Moderate plausibility.
Benznidazole is contraindicated in patients with Cockayne syndrome. Cases of severe irreversible hepatotoxicity/acute liver failure with fatal outcomes have been reported after start of metronidazole (another nitroimidazole drug structurally related to benznidazole) in patients with Cockayne syndrome.
Benznidazole (applies to benznidazole) bone marrow depression
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Bone Marrow Depression/Low Blood Counts
Hematological manifestations of bone marrow depression (e.g., neutropenia, thrombocytopenia, anemia, and leukopenia) have been reported with the use of benznidazole; these resolved after treatment was discontinued. Only under strict medical supervision should benznidazole be taken by patients with hematological manifestations of bone marrow depression. Complete blood count should be monitored; total and differential leukocyte counts are recommended before, during, and after therapy.
Benznidazole (applies to benznidazole) liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
The use of benznidazole has not been evaluated in patients with liver dysfunction; caution is recommended.
Benznidazole (applies to benznidazole) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
The use of benznidazole has not been evaluated in patients with renal dysfunction; caution is recommended.
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Benznidazole drug interactions
There are 133 drug interactions with benznidazole.
Benznidazole alcohol/food interactions
There is 1 alcohol/food interaction with benznidazole.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.