Generic Name: von willebrand factor recombinant (Intravenous route)
Von WILL-a-brand FAK-tor re-KOM-bin-ant
Medically reviewed on June 7, 2018
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Hemostatic
Uses For Vonvendi
Von Willebrand factor recombinant injection is used to treat and control serious bleeding episodes in patients with a bleeding problem called von Willebrand disease (VWD). Von Willebrand factor is normally produced in the body and it helps you form blood clots. Patients with von Willebrand disease do not make enough of this substance to prevent bleeding, so this product is given to increase the blood levels.
Von Willebrand factor recombinant injection is also used to manage bleeding before surgery in patients with von Willebrand disease.
This medicine is available only with your doctor's prescription.
Before Using Vonvendi
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of von Willebrand factor recombinant injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies have not been performed on the relationship of age to the effects of von Willebrand factor recombinant injection in geriatric patients.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Blood clots, history of or
- Disseminated intravascular coagulation (DIC, blood clots all over the body), history of or
- Heart attack, recent or
- Pulmonary embolism (blood clot in lungs), history of or
- Stroke, history of—Use with caution. May make these conditions worse.
Proper Use of Vonvendi
A nurse or other trained health professional will give you this medicine in a hospital or clinic. It is given through a needle placed into one of your veins.
This medicine may also be given at home to patients who do not need to be in a hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to prepare and inject the medicine. Make sure you understand all of the instructions before giving yourself an injection.
Your dose may change based on where you are bleeding. Do not use more medicine or use it more often than your doctor tells you to.
Precautions While Using Vonvendi
It is very important that your doctor check your progress closely while you are receiving this medicine to make sure it is working properly. Blood tests are needed to check for unwanted effects.
This medicine may increase your chance of having blood clots. Tell your doctor right away if you have a sudden or severe headache, problems with vision or speech, chest pain, or numbness or weakness with this medicine.
This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you get the injection.
Vonvendi Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
- Chest discomfort
- fast, pounding, or irregular heartbeat or pulse
Incidence not known
- Blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- coughing or spitting up blood
- difficulty with swallowing
- discoloration of the skin
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- hives or welts, itching, or skin rash
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- redness of the skin
- tightness in the chest
- trouble breathing
- unusual drowsiness, dullness, tiredness, weakness or feeling of sluggishness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feeling at the infusion site
- change in taste
- feeling of warmth
- loss of taste
- redness of the face, neck, arms, and occasionally, upper chest
- shakiness in the legs, arms, hands, or feet
- sudden sweating
- trembling or shaking of the hands or feet
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: miscellaneous coagulation modifiers