Skip to Content

Medications for Monkeypox Prophylaxis

About Monkeypox Prophylaxis

Monkeypox prophylaxis is when measures are taken to prevent monkeypox in people who are considered to be at high risk of being infected with monkeypox virus (MPXV). Monkeypox is a virus that belongs to the same virus family as cowpox, smallpox and vaccinia. The pox viruses cause pox lesions and can leave pockmark scars after the rash has healed.

Infection of Monkeypox

Monkeypox is a rare infection that is indigenous to rain forests of western and central Africa and is only occasionally reported outside of these areas. The monkeypox virus is linked to animals including rabbits, squirrels, monkeys, gazelles and rats. People can become infected with monkeypox virus if there is direct contact with infected animals or during butchering and meal preparation, if the animals are used as meat sources. Human-to-human transmission is thought to occur with respiratory droplets and direct contact with the skin lesions.

Symptoms of Monkeypox

The time from exposure to first when symptoms appear averages at 12 days, but it can range from 4 and 20 days.  Symptoms start with fever, chills sweats headache, muscle pain, short of breath, cough and general feelings of being unwell. After a couple of days the lymph nodes become swollen. Up to 10 days after the first signs of infection a rash starts usually on the face and spreads over the body.  The rash progresses into fluid-filled spots that then ulcerate, scab over and then heal, often leaving pockmark scars.

Prevention of Monkeypox

Prevention of monkeypox is by avoiding contact with infected animals and by reducing person to person transmission by isolating infected people, with caregivers following good infection containment practices. 

Adults that are at high risk of monkeypox infection can be vaccinated with monkeypox vaccine.

Drugs used to treat Monkeypox Prophylaxis

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
smallpox and monkeypox vaccine Rate Add review
Rx U

Generic name: smallpox and monkeypox vaccine systemic

Brand name:  Jynneos

For consumers:

For professionals: A-Z Drug Facts

Jynneos Rate Add review
Rx U

Generic name: smallpox and monkeypox vaccine systemic

For consumers:

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Browse Treatment Options

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.