Serzone User Reviews & Ratings

• Tia
• Taken for 10 years or more
• April 24, 2021

For Depression "I was crippled by panic attacks that didn’t subside completely for about 2 years. I couldn’t drive by myself, I lost too much weight, & it turned into agoraphobia. The doctor put me on Serzone & I got my life back! I had no side effects & had a yearly blood labs taken to ensure there were no issues with my liver. After being on nefazodone for 26 years (while living a full life) this drug has been discontinued. I’ve been tapering off but the side effects are debilitating. I have irregular heart beat, hot or extreme cold in my extremities, I feel like I have the flu, body aches & pains, headaches (which I normally never get), extreme hunger, nausea, my moods are all over & manic, and of course my panic attacks have returned with a vengeance! I wish they would continue to make this medicine again as my life has slipped back into the prison of my life prior to nefazodone. I would even fly to another country to get scripts if there was a supply elsewhere."

• Zsa...
• Taken for 10 years or more
• March 18, 2020

For Depression "After having a baby in 1991 I came down with postpartum depression. I tried everything on the market. I went through a few doctors, a few hospital stays and a few experiences with charcoal due to no longer wanting to fight to exist any longer. Finally my doctor tried one last medication on me as I wouldn't take anything that affected my weight (gaining), my sex drive or could cause Tardive dyskinesia. My doctor started me on Nefazodone, a generic for Serzone. What a difference Nefazodone made in my life. My Doc found a dose that worked for me until my mother passed away. That's when he added Lamictal, a mood stabilizer. I am now off of the Lamictal, but, continued the Nefazodone taking two 100mg a day at bedtime, I am finally at a pretty happy spot in my life and I know that without my amazing therapist and Nefazodone I wouldn't be here today!!!"

• Birdie...
• Taken for 10 years or more
• June 8, 2019

For Depression "I was first diagnosed with depression, generalized anxiety disorder, panic attacks and social anxiety disorder about 18 years ago. Under the guidance of a psychiatrist and a psychologist, I was prescribed a fairly new drug - Serzone. Relief came within 1/2 hour after taking my first dose. I have no side effects. It is a fabulous drug."

• sonnyi
• July 23, 2012

For Depression "Was on Serzone for 10 years. The best antidepressant ever and I have been on most of them since my tour in Vietnam. No sexual side effects on like SSRI`s or SNRI`s. Then they took it off the market. Just recently went back to nefazodone. Serzone works so good."

• Nicole
• February 10, 2018

For Depression "Serzone was a miracle drug for me. I’ve tried almost every anti-depressant and they all had horrible side effects and did nothing to alleviate my depression. Serzone made me feel like I could finally see things clearly. I felt as if a veil had been lifted and no longer felt like I was in a fog. Whereas before going for a walk, cleaning house, self-care seemed like a monumental feat, after serzone everything became easy. I didn’t feel like these tasks were an insurmountable hurdle. Basic tasks became simple and I could finally see beyond my depression. I write this now as I’m back to suffering severe depression and searching for a drug similar to serzone as I think they took it off the market."

• mumchik
• March 1, 2009

For Depression "I took this drug for 8 months and it cured my depression which is usually unheard of. When I asked for it again several years later for post-partum after having my last child I was told it was taken off the market. Why?? Because it actually CURED people - I don't get it."

• PW_in...
• Taken for 10 years or more
• April 15, 2019

"I starting experiencing anxiety and panic attacks in graduate school at age 22 and was diagnosed with hypochondriasis and agoraphobia a few years later. For 20+ years thereafter I tried more than two dozen medications, including benzodiazepines, tricyclics, AMOIs, and SSRIs, all with no success. At age 48 my new psychiatrist recommended that I try Serzone (nefazodone) along with a small dose (1 mg at bedtime) of Klonopin (clonazepam). This combination worked tremendously. I have taken both medications continuously for 25 years (I'm 67 now) and I haven't suffered a panic attack, or from hypochondiasis or agoraphobia since 1995. I take 200 mg of nefazodone per day (at bedtime)."

• An...
• Taken for 5 to 10 years
• December 27, 2014

For Depression "My PCP prescribed Serzone for me after I described typical symptoms of depression. As an RN I didn't want to feel "medicated" & never did. This medicine gave me back myself. I was on it for about 4 yrs then switched to Paxil for about 2 yrs and then taken off all together. I haven't been on any medicines for depression in 7 yrs as my divorce is long over & I am well healed - Amen! I would recommend Serzone regular lab work & doctor's care. Also, talk therapy helps too!"

• natur...
• March 19, 2011

For Depression "I was on Serzone for 6 years and it gave me my life back. It truly is a miracle medicine and should not get the bad rap. I never had any liver problems, in fact I only had dry mouth as a side-effect. It did not affect my libido or ability like the Cymbalta that I am on now. I had liver problems with Depakote ER and I don't understand why it does not get the negative press. Serzone is amazing and I am going to work with my new psychiatrist to be back on it once again. I can't wait to get my life back once again!"

• harpi...
• March 26, 2011

For Anxiety "I have been using Serzone and the generic versions for over 15 years now. When the brand was pulled from the market, I tried Wellbutron, Celexa and Prozac. All three had horrible side effects and I finally found a doctor who would prescribe me the generic of Serzone again. This medication keeps me on an even keel, keeps the anxious thoughts from overwhelming me and helps me sleep at night. My liver panels are always perfect and my only side effect is that I have to take it right before I go to bed as it makes me sleepy."

• valley
• Taken for 10 years or more
• February 23, 2019

For Depression "I went on Elavil to try to help severe migraine. While it was somewhat helpful for the headaches, it immediately began making me gain weight. I put on 40 pounds, and it was a shock because I had never been overweight before. I was 42. I changed doctors, and she put me on Serzone. Within a week I dropped 4 pounds! I was so excited, I began walking again and trying to lose weight. Overall, I lost the 40 pounds and kept it off. Then Serzone was banned, and I had to change antidepressants. The weight piled on, and in six months I gained 60 pounds on Cymbalta. Now, I’m in my late 60s and my new doctor refuses to let me try Nefazodone , which is now available again. I’m so angry. I’ve dropped that doc and am going to a new psychiatrist next week. Here’s hoping she is more brave and understanding and will let me switch to Nefazodone. I hope I can still lose weight even though I’m 25 years older. Being overweight makes me more depressed than any of my life’s problems."

• Hope
• May 27, 2009

For Depression "I have taken this antidepressant for as long as it has been on the market. It was and remains the only antidepressant that works for me. It has almost zero side effects when compared to the Tri-cyclics, SSRIs and SNRIs that I tried before this drug. It is in a class by itself and unfortunately will probably remain so. This antidepressant gave me back my life, calmed my panic attacks and even helped with social phobia. It is too bad that it has been given such a bad rap that it is hardly prescribed anymore."

• marky...
• December 17, 2009

For Depression "I started taking this drug for chronic daily headaches in 1999. Turns out they were caused by stress & serious depression. The Serzone was a miracle drug for me! I saw the world so much more clearly and without the negative lens. My headaches were gone (turns out it actually has a patent for preventing migraines!). I was on it for 8 years until I moved to a new city and had trouble finding doctors to write for it. So I was off it the last two years, and my doctor had me on awful Depakote instead. I hated it! I found a doctor this week to put me back on Nefazodone (Serzone). I look forward to ramping up the dosage and feeling alive again! It was a great drug for me without sexual side effects, which is important to many men."

• Teton
• December 24, 2017

For Depression "I was in a major depression after my baby died in the second trimester. Thoughts of suicide, the works. When I finally reached out for help I was put on serzone....truly a miracle drug. I was young, 28 and never had side effects. After a year I weaned off. Three years later I had my daughter and started spiralling downward, post partum - after you have a baby it is supposed to be the happiest time! I reached out for help and could no longer obtain serzone. I have literally been on EVERY antidepressant for the past 16 years. Nothing has worked like serzone. I am in a bad spot depression-wise again and am thinking it will be worth the liver risk to try to feel normal again."

• mabe
• December 10, 2009

For Panic Disorder "I was having many panic attacks and could barely manage my life. I started Serzone with the few side effects of dry mouth, sleepiness at first, and constipation. Only the dry mouth remains. I have now been on it ten years through many major stress issues. It has kept me functional through all these, and I have avoided breakdowns that could have occurred. (On measures of stress tests, I usually rank in the "Go to the Hospital" area). No liver problems, and it is tested yearly. I have had to slightly up the dosage two years ago. I did have a horrible time in trying to quickly change to another drug when it appeared that serzone was going out of production. I am grateful for it, and wish it was more widely used"

• NCCHICK
• July 8, 2009

For Depression "I have just started on Serzone (Nefazodone) after reading up on it. I have tried so many other SSRI's that did not work so I am hoping that this class of drug will. I wish people wouldn't worry about the the liver issue. Depakote and Cymbalta both have the same risk but they haven't been pulled off the market due to the bad rap. I decided to try Serzone regardless of the liver issue. I will have my liver checked at least every 6 months and if it becomes abnormal, I will stop taking Serzone. No big deal. It is as simple as that. But I read that the risk is only about 1 in 250,000. I will take those odds if this drug really helps me. So far I feel drowsy but I can live with that. The alternative is debilitating fatigue and horrible negativity."

• Anonymous
• September 21, 2009

For Depression "Serzone is the only one that has helped me and I've never had any liver problems that are associated with it. It makes me feel better right away. Really though I am certifiably depressed and it works. If nothing else works then try this. If the ones you are on work, then by all means don't, thanks."

• Anonymous
• July 21, 2009

For Depression "It is one of best of the many I have tried over the last twenty years. Many others either eliminated libido and/or stopped working after a relatively short time. The only side effect noticed is oily skin."

• Anonymous
• January 21, 2010

For Depression "I love this medicine. I feel happy & energetic & nothing else helped at all."

• Misti...
• Taken for 1 to 6 months
• March 4, 2015

For Major Depressive Disorder "Minimal side effects. Last resort after many years on other antidepressants that I couldn't tolerate the side effects with or just plain didn't work"

• Anonymous
• March 12, 2009

"This medicine helped me when others didn't, and I had no side effects."