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Primary Immune Deficiency Disorder


A primary immune deficiency disorder (PIDD) means your immune system did not develop correctly, or does not work correctly. This increases your risk for infections and certain cancers. Infections you had before, such as tuberculosis, may also become active again. Your immune system may also attack healthy cells instead of harmful cells.


Seek care immediately if:

  • You have sudden or severe trouble breathing.

Contact your healthcare provider if:

  • You have a fever that does not come down with medicine, such as acetaminophen.
  • You have new or worsening symptoms.
  • You have questions or concerns about your condition or care.


  • Antibiotics may be given to prevent or treat a bacterial infection.
  • Take your medicine as directed. Contact your healthcare provider if you think your medicine is not helping or if you have side effects. Tell him or her if you are allergic to any medicine. Keep a list of the medicines, vitamins, and herbs you take. Include the amounts, and when and why you take them. Bring the list or the pill bottles to follow-up visits. Carry your medicine list with you in case of an emergency.

Manage a PIDD:

The following are ways you can help prevent infection and protect or build your immune system:

  • Wash your hands often. This can help prevent infection and the spread of germs. Use soap and warm water. Wash your hands after you change a child's diaper and before you prepare or eat food. Use an alcohol-based hand rub if soap and water are not available. Carry gel with you when you leave the house. Dry your hands before you use hand rub. Rub your hands together until all of the liquid has dried.
  • Avoid crowds during flu season. Flu season is from late October to the middle of March. Do not have close contact with someone who is sick. Stay 3 to 6 feet away from people when you are in public. Ask friends and family to visit only when they are not sick.
  • Ask about vaccines you may need. Get the flu vaccine every year when it becomes available. You may also need the pneumonia vaccine every 5 years. Ask your healthcare provider for more information about vaccines.
  • Eat a variety of healthy foods. Healthy foods help your immune system work better. Healthy foods include fruits, vegetables, whole-grain breads, fish, lean meats, low-fat dairy products, and cooked beans.
  • Exercise as directed. Exercise can help keep your lungs clear. This will help decrease your risk for a lung infection. Do not exercise outdoors in cold weather or in an area that has pollution.
  • Protect your mouth from germs that lead to infection. Brush your teeth at least 2 times per day. See your dentist at least every 6 months.
  • Do not smoke. Nicotine and other chemicals in cigarettes and cigars can cause lung damage. Ask your healthcare provider for information if you currently smoke and need help to quit. E-cigarettes or smokeless tobacco still contain nicotine. Talk to your healthcare provider before you use these products.
  • Ask if you need to be screened for cancer. A PIDD can increase your risk for certain cancers. Regular screening can help find cancer early.

Follow up with your doctor as directed:

Write down your questions so you remember to ask them during your visits.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

Learn more about Primary Immune Deficiency Disorder (Discharge Care)

Associated drugs

IBM Watson Micromedex

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.