IV Infiltration
Medically reviewed by Drugs.com. Last updated on Sep 23, 2025.
What is IV infiltration?
IV infiltration happens when fluid or medicine leaks into the tissue around your IV site. This can happen if the IV moves out of your vein or pokes through the vein wall. Some medicines can cause more harm than others. These include chemo, some antibiotics, contrast liquid, or blood pressure medicines.
What increases my risk for IV infiltration?
You may have a higher risk if:
- Your IV is in an area with little soft tissue
- A large needle is used
- You need IV treatment often
What are the signs and symptoms of IV infiltration?
These signs and symptoms may develop at your IV site:
- Fluid leaking
- Sharp or burning pain
- Swelling, firm, or hard skin
- Cool or pale skin
- Blisters or sores
- Numbness or tingling
- Skin stays pale after you press and let go
How is IV infiltration treated?
Medicines may be given to decrease pain or swelling. You may also need medicine to treat what leaked into your tissue.
How should I care for my IV site at home?
- Use a cold or warm pack as directed. Your healthcare provider will tell you which to use according to the type of infiltrated fluid.
- Elevate your arm above the level of your heart as directed. This helps decrease swelling and pain. Rest your arm of pillows or soft blankets.
- Do not use soap, lotion, or cream on the area. Ask your provider what to use to clean and cover the area.
When should I seek immediate care?
- You develop a fever higher than 101ºF (38.3°C).
- Your symptoms get worse.
- You see thick or bloody drainage at the IV site.
- Your skin turns dark red, purple, or black.
- Your sores get worse or your skin starts to peel.
When should I call my doctor?
- You have a fever.
- You have questions or concerns about your condition or care.
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Further information
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