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Mequinol/ tretinoin

Generic Name: mequinol/tretinoin (ME-kwi-nole/TREH-tih-noyn)
Brand Name: Solage

Mequinol/ tretinoin is used for:

Treating solar lentigines (darkened lesions on skin that has been exposed to sunlight over a long period of time). Mequinol/tretinoin is used with a total skin care and sunlight avoidance program. It may also be used for other conditions as determined by your doctor.

Mequinol/tretinoin is a combination depigmentation agent and retinoid. Exactly how it works is unknown.

Do NOT use mequinol/ tretinoin if:

  • you are allergic to any ingredient in mequinol/tretinoin
  • you are taking a fluoroquinolone (eg, levofloxacin), a phenothiazine (eg, chlorpromazine), a sulfonamide (eg, glipizide, sulfamethoxazole), a tetracycline (eg, doxycycline), a thiazide diuretic (eg, hydrochlorothiazide), or other medicines that may increase your skin's sensitivity to the sun. Ask your doctor or pharmacist if you have questions about whether any of your medicines increase your skin's sun sensitivity.
  • you are pregnant or may become pregnant

Contact your doctor or health care provider right away if any of these apply to you.

Before using mequinol/ tretinoin:

Some medical conditions may interact with mequinol/tretinoin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have eczema, irritated or inflamed skin, an increased number of white blood cells, vitiligo (loss of skin pigmentation), or sunburn
  • if you are unusually sensitive to sunlight or must be outside for prolonged periods of time

Some MEDICINES MAY INTERACT with mequinol/tretinoin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Fluoroquinolones (eg, levofloxacin), phenothiazines (eg, chlorpromazine), sulfonamides (eg, glipizide, sulfamethoxazole), tetracyclines (eg, doxycycline), or thiazide diuretics (eg, hydrochlorothiazide) because the risk of sunburn may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if mequinol/tretinoin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use mequinol/ tretinoin:

Use mequinol/tretinoin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with mequinol/tretinoin. Talk to your pharmacist if you have questions about this information.
  • Mequinol/tretinoin is for external use only.
  • Use mequinol/tretinoin twice daily, at least 8 hours apart, unless directed otherwise by your doctor.
  • Remove all cosmetics with a mild soap before applying mequinol/tretinoin. Gently dry the area. Wait 20 to 30 minutes to make sure that skin is completely dry.
  • Use the applicator tip to apply mequinol/tretinoin to the affected area. Use only enough to make the lesion appear moist. Avoid getting mequinol/tretinoin on the surrounding, normally colored skin.
  • Do not shower or bathe the treated areas for at least 6 hours after you apply mequinol/tretinoin.
  • Wait 30 minutes after applying mequinol/tretinoin before you apply cosmetics.
  • If you miss a dose of mequinol/tretinoin, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use mequinol/tretinoin.

Important safety information:

  • Avoid getting mequinol/tretinoin in your eyes, on the inside or angles of your nose, or in your mouth. If you get mequinol/tretinoin in your eyes, rinse thoroughly with water.
  • Mequinol/tretinoin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to mequinol/tretinoin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Talk with your doctor before you use any other medicines or products on your skin. While you are using mequinol/tretinoin, you may use cosmetics.
  • Do not apply mequinol/tretinoin to skin that is sunburned. Wait until the burn is fully healed before using mequinol/tretinoin.
  • Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Safety and effectiveness of mequinol/tretinoin have not been established in patients with moderately dark to dark skin.
  • Avoid using other topical medication, cosmetics, or other products that have a strong drying effect. If you have dry skin from using these products, allow your skin to "rest" before using mequinol/tretinoin.
  • If the lesion you have been treating becomes the same color as your normal skin, contact your doctor.
  • Do not use mequinol/tretinoin on skin with eczema, or for any condition other than that for which it was prescribed.
  • Weather extremes, such as windy or cold weather, may irritate your skin more while you are using mequinol/tretinoin.
  • Mequinol/tretinoin may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
  • Mequinol/tretinoin should only be used in addition to a comprehensive skin care and sunlight avoidance program prepared by your doctor.
  • Mequinol/tretinoin is flammable. Do not store or use near an open flame or while smoking.
  • If you are able to become pregnant, use effective birth control while you are using mequinol/tretinoin.
  • Mequinol/tretinoin should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use mequinol/tretinoin if you are pregnant. If you think you may be pregnant, contact your doctor immediately. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use mequinol/tretinoin, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of mequinol/ tretinoin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning, dry skin, itching, peeling, redness, stinging, tingling, or warmth at application site; unusual sensitivity to wind and cold.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering, crusting, swelling, or excessive redness of the skin; changes in skin color; lightening of the skin surrounding the treatment area.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include clumsiness; dizziness; excessive redness, peeling, and discomfort; flushing; headache; stomach pain.

Proper storage of mequinol/tretinoin:

Store mequinol/tretinoin at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat and light. Do not store in the bathroom. Keep mequinol/tretinoin out of the reach of children and away from pets.

General information:

  • If you have any questions about mequinol/tretinoin, please talk with your doctor, pharmacist, or other health care provider.
  • Mequinol/tretinoin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take mequinol/tretinoin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about mequinol/tretinoin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to mequinol/tretinoin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using mequinol/tretinoin.

Issue Date: June 3, 2015

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.