Generic Name: Ruxolitinib (rux oh LI ti nib)
Brand Name: Jakafi
Medically reviewed on May 2, 2018
Uses of Jakafi:
What do I need to tell my doctor BEFORE I take Jakafi?
- If you have an allergy to ruxolitinib or any other part of Jakafi (ruxolitinib).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have an infection.
- If you have any of these health problems: Kidney disease or liver disease.
- If you are taking fluconazole.
- If you are breast-feeding. Do not breast-feed while you take Jakafi (ruxolitinib) and for 2 weeks after your last dose.
This is not a list of all drugs or health problems that interact with Jakafi (ruxolitinib).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Jakafi (ruxolitinib) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Jakafi?
- Tell all of your health care providers that you take Jakafi (ruxolitinib). This includes your doctors, nurses, pharmacists, and dentists.
- You may only get Jakafi (ruxolitinib) from certain pharmacies.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- If you have had TB (tuberculosis) or have been close to someone who has TB, talk with your doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Have your skin checked as you have been told by your doctor. Talk with your doctor.
- Avoid grapefruit and grapefruit juice.
- Some patients have had very bad health problems after stopping Jakafi (ruxolitinib). Do not stop taking Jakafi (ruxolitinib) without calling your doctor. Call your doctor right away if you stop Jakafi (ruxolitinib) and you have a fever, trouble breathing, signs of low blood pressure like very bad dizziness or passing out, or any bruising or bleeding. Call your doctor right away if you stop Jakafi (ruxolitinib) and you have signs of organ problems like a change in how much urine is passed, dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes. You may need to start taking Jakafi (ruxolitinib) again.
- Treatment with Jakafi (ruxolitinib) may lead to higher cholesterol and triglycerides. The effect of these changes on heart health is not known. Talk with the doctor.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Jakafi (ruxolitinib) while you are pregnant.
How is this medicine (Jakafi) best taken?
Use Jakafi (ruxolitinib) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- To gain the most benefit, do not miss doses.
- Keep taking Jakafi (ruxolitinib) as you have been told by your doctor or other health care provider, even if you feel well.
- Take with or without food.
- Those who have feeding tubes may also use the tablet. Mix each tablet with 40 mL of water. Stir for 10 minutes. Give within 6 hours of mixing. Flush the feeding tube with water before and after Jakafi (ruxolitinib) is given.
- If you are on dialysis and are taking Jakafi (ruxolitinib) on the day you get dialysis, take it after your dialysis. If you have questions, talk with your doctor.
What do I do if I miss a dose?
- Never make up a missed dose. Skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Painful skin rash with blisters.
- Upset stomach or throwing up.
- Shortness of breath.
- Feeling tired or weak.
- A very bad brain problem called progressive multifocal leukoencephalopathy (PML) has happened with Jakafi (ruxolitinib). It may cause disability or can be deadly. Tell your doctor right away if you have signs like confusion, memory problems, low mood (depression), change in the way you act, change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.
- Certain types of skin cancer have happened in people taking Jakafi (ruxolitinib). Call your doctor right away if you have a change in color or size of a mole, or any new or changing skin lump or growth.
What are some other side effects of Jakafi?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Loose stools (diarrhea).
- Hard stools (constipation).
- Muscle spasm.
- Belly pain.
- Weight gain.
- Nose and throat irritation.
- Joint pain.
- Upset stomach.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Jakafi?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Jakafi (ruxolitinib), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Jakafi (ruxolitinib)
- Jakafi Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Compare Alternatives
- Support Group
- Pricing & Coupons
- En Español
- 6 Reviews – Add your own review/rating
- Drug class: multikinase inhibitors