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Pyrilamine use while Breastfeeding

Drugs containing Pyrilamine: Triplex AD, Midol Maximum Strength Menstrual, Midol PMS, Codituss DM, Pamprin Maximum Pain, Tanoral, Pamprin Multi-Symptom Menstrual Relief, Syncol, Nalex A 12, Capron DM, Show all 162 »Poly-Histine, AllerTan, Menstrual PMS, Pyril D, Menstrual Pain Relief, Tri-Histine, Hycomal DH, Vetuss HC Syrup, Dicomal-DH, PhendaCof Plus, De-Chlor MR, Tussplex, Poly Hist HC, Delhist D, Multihistamine-D, Trimal DH, Mintuss MR, Codal-DH Syrup, Hydrophene DH, Codituss DH, Hyco-DH, Ryna-12X, Codimal DM, Reme Hist DM, Pryil DM, Triplex DM, Viratan-DM, Zotex-12, Deconsal DM Tannate, Aldex DM, MyHist-DM, Tannate V DM, Multihistamine-D Ped, A-Tan 12X, Rolatuss with Hydrocodone, Poly Hist DHC, Viravan-PDM, Ru-Hist Plus, Deconsal DM, Ru-Tuss with Hydrocodone, Trihist-D, Pyril Tann-12, Viravan-S, V-Tann, R-Tannic-S A/D, Poly Hist Forte (old formulation), K-Tan, Ryna-12, Pyril Mal Phenyl HCl, Ry-T-12, Deconsal CT Tannate, Ru-Hist D (old formulation), Viravan-P, Pyrlex, Ryna-12S, Pyrlex PD, Aldex D, Rynesa 12S, K-Tan 4, Viravan-T, Polytine D, V-Tan DM, Liqui-Histine-D, Metahistine D, Prohistine-D, Delhistine D, Poly-Histine-D, KG-Hist D, Iohist D, Quadra-Hist D, Myci Spray, Deconsal CT, Quadra-Hist D Pediatric, Liqui-Minic Infant, Histine-D, Uni-Multihist D Ped, Poly-D, ProHist, Rynatan-S Pediatric, R-Tannate Pediatric, Gelhist Pediatric, Atrohist Pediatric, Vanex Forte, Pro-Chlo, Ninjacof, Histalet Forte, R-Tannate, Triotann-S, Triple Tannate Pediatric, Tri-Tannate, Tanamine Pediatric, Equitan Pediatric, Tanoral Pediatric, R-Tannamine Pediatric, Triotann-S Pediatric, Pyrlex CB, Corzall Plus, Premsyn PMS, PMS Formula Multi-Symptom, PMS Relief, Midol PMS Maximum Strength, Covangesic, Menstrual Relief, Menstrual Complete, Ninjacof-A, HistaFlex, Dermagesic, Tannate 12D S, Tussi-12D, Zotex-D, Tannihist-12D, C-Tanna 12D, Z-Xtra, Tussi-12D S, Tri-Tannate Pediatric, Rhinatate Pediatric, Pro-Red AC (old formulation), Dicomal-PH, Neo AC, Codimal PH, Zotex-C, Poly Hist PD (old formulation), Phena-S 12, MyHist-PD, Pro-Clear AC, Poly Tan DM, Resperal, Nalfrx, Codal-DM Syrup, P-Hist, Coryza-DM, Poly Tan D, Poly Tan, Pyrichlor PE, Conal, R-Tannamine, URL-Tannate, Triotann, Tanamine, Tritan, Rhinatate, Url-Tannate Pediatric, Ru-Hist Forte, Histatan, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Tri-Gestan S, Chlorex-A 12, Phena-S, Triotann Pediatric, Viravan-DM

Pyrilamine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. One early study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in 3 women, drug levels in milk ranged from 50 to 2.3 mg/L at 1 to 2 hours after the dose and 220 mcg/L to 4 mg/L 5 hours after the dose. Eight hours after the dose, levels were 200 mcg/L and 1.16 mg/L in two mothers, respectively, and not measured in the third.[1] No studies using modern assay methods have been reported.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.[2]

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.

2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Pyrilamine Identification

Substance Name

Pyrilamine

CAS Registry Number

91-84-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

232

Last Revision Date

20150310

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