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Pyrilamine use while Breastfeeding

Drugs containing Pyrilamine: Midol PMS, Ninjacof, Codimal DM, Triplex DM, Midol PMS Maximum Strength, Pamprin Maximum Pain, Pamprin Multi-Symptom Menstrual Relief, Triplex AD, Tanoral, Tussi-12D, Show all 165 »Menstrual Complete, Neo AC, Capron DM, Histine-D, Triotann-S Pediatric, Poly Hist Forte (old formulation), Midol Maximum Strength Menstrual, PMS Relief, Hycomal DH, Ryna-12X, A-Tan 12X, Rolatuss with Hydrocodone, Ru-Tuss with Hydrocodone, Vetuss HC Syrup, PhendaCof Plus, Dicomal-DH, Ryna-12S, Hyco-DH, Codal-DH Syrup, Hydrophene DH, Codituss DH, De-Chlor MR, Mintuss MR, Poly Hist DHC, Viravan-S, Tussplex, Viratan-DM, Viravan-P, V-Tan DM, Zotex-12, Deconsal DM Tannate, Aldex DM, Pyril D, Codituss DM, Viravan-PDM, Reme Hist DM, Pryil DM, Ru-Hist D (old formulation), MyHist-DM, Tannate V DM, Ru-Hist Plus, Deconsal DM, Trimal DH, Poly Hist HC, Pyril Tann-12, Deconsal CT, Quadra-Hist D, Poly-Histine, Deconsal CT Tannate, Tri-Histine, Myci Spray, Ry-T-12, Viravan-T, Rynesa 12S, K-Tan 4, K-Tan, Ryna-12, V-Tann, Pyril Mal Phenyl HCl, R-Tannic-S A/D, Aldex D, Quadra-Hist D Pediatric, Pyrlex PD, Prohistine-D, Delhist D, Multihistamine-D, Multihistamine-D Ped, Poly-D, Delhistine D, Poly-Histine-D, Viravan-DM, Liqui-Minic Infant, Polytine D, Trihist-D, Liqui-Histine-D, KG-Hist D, Iohist D, Uni-Multihist D Ped, Metahistine D, Coryza-DM, Codal-DM Syrup, Rynatan-S Pediatric, Corzall Plus, Pyrlex CB, Pro-Chlo, Histalet Forte, Vanex Forte, Atrohist Pediatric, R-Tannate Pediatric, Tannate 12D S, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannamine Pediatric, Tanoral Pediatric, Equitan Pediatric, Triple Tannate Pediatric, Zotex-D, Tannihist-12D, Tanamine Pediatric, Menstrual Relief Multi-Symptom, Menstrual Relief Extra Strength, Menstrual Relief Maximum Strength, Menstrual Relief, Ninjacof-A, Covangesic, Premsyn PMS, Menstrual PMS, C-Tanna 12D, Menstrual Pain Relief, Syncol, PMS Formula Multi-Symptom, HistaFlex, Dermagesic, Z-Xtra, Tussi-12D S, Tri-Tannate, Tri-Tannate Pediatric, Nalfrx, Pro-Red AC (old formulation), Pyrichlor PE, Poly Hist PD (old formulation), Phena-S 12, MyHist-PD, Zotex-C, Codimal PH, Dicomal-PH, AllerTan, Pro-Clear AC, Poly Tan DM, Poly Tan D, Poly Tan, ProHist, P-Hist, Resperal, Conal, Nalex A 12, Rhinatate Pediatric, Triotann, Rhinatate, Url-Tannate Pediatric, Tritan, Tanamine, R-Tannamine, URL-Tannate, Ru-Hist Forte, Tri Tann Pediatric, Histatan, Phena-S, Triotann Pediatric, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Pyrlex

Pyrilamine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. One early study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in 3 women, drug levels in milk ranged from 50 to 2.3 mg/L at 1 to 2 hours after the dose and 220 mcg/L to 4 mg/L 5 hours after the dose. Eight hours after the dose, levels were 200 mcg/L and 1.16 mg/L in two mothers, respectively, and not measured in the third.[1] No studies using modern assay methods have been reported.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.[2]

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.

2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Pyrilamine Identification

Substance Name

Pyrilamine

CAS Registry Number

91-84-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

232

Last Revision Date

20150310

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