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Pyrilamine use while Breastfeeding

Drugs containing Pyrilamine: Midol PMS, Midol Maximum Strength Menstrual, Triplex DM, Ru-Hist Forte, Capron DM, Tanoral, Pyril D, Poly Hist HC, Delhistine D, Viravan-T, Show all 165 »Triplex AD, Triotann, Ninjacof, Menstrual Relief Maximum Strength, Viravan-S, Zotex-C, Pamprin Maximum Pain, Neo AC, Trimal DH, Mintuss MR, Tussplex, V-Tan DM, Hyco-DH, De-Chlor MR, Codituss DH, Hycomal DH, Dicomal-DH, PhendaCof Plus, Hydrophene DH, Codal-DH Syrup, Vetuss HC Syrup, Ryna-12X, Reme Hist DM, Pryil DM, MyHist-DM, Codituss DM, Codimal DM, Deconsal DM Tannate, Viratan-DM, Tannate V DM, Ru-Hist Plus, Aldex DM, A-Tan 12X, Rolatuss with Hydrocodone, Poly Hist DHC, Zotex-12, Deconsal DM, Viravan-PDM, Ru-Tuss with Hydrocodone, Metahistine D, Poly Hist Forte (old formulation), R-Tannic-S A/D, Pyril Tann-12, Pyril Mal Phenyl HCl, Ryna-12, Deconsal CT, K-Tan 4, K-Tan, V-Tann, Ry-T-12, Ru-Hist D (old formulation), Viravan-P, Pyrlex, Ryna-12S, Pyrlex PD, Deconsal CT Tannate, Aldex D, Rynesa 12S, Myci Spray, Tri-Histine, Viravan-DM, Polytine D, Trihist-D, Prohistine-D, Poly-Histine-D, Multihistamine-D, Multihistamine-D Ped, Poly-D, Liqui-Histine-D, KG-Hist D, Quadra-Hist D Pediatric, Quadra-Hist D, Poly-Histine, Liqui-Minic Infant, Uni-Multihist D Ped, Iohist D, Histine-D, Delhist D, Coryza-DM, Pyrlex CB, Pro-Chlo, Histalet Forte, Corzall Plus, Zotex-D, Tannihist-12D, Tannate 12D S, Tussi-12D, Vanex Forte, Atrohist Pediatric, R-Tannamine Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Triotann-S, R-Tannate, Rynatan-S Pediatric, R-Tannate Pediatric, Gelhist Pediatric, C-Tanna 12D, Tussi-12D S, Midol PMS Maximum Strength, Premsyn PMS, Menstrual Relief Multi-Symptom, Covangesic, Ninjacof-A, Menstrual Relief Extra Strength, Menstrual Relief, Menstrual Complete, Menstrual PMS, Menstrual Pain Relief, HistaFlex, Dermagesic, Z-Xtra, Pamprin Multi-Symptom Menstrual Relief, PMS Relief, Syncol, PMS Formula Multi-Symptom, Equitan Pediatric, Triple Tannate Pediatric, MyHist-PD, Codimal PH, Pro-Red AC (old formulation), Phena-S 12, Poly Hist PD (old formulation), AllerTan, Conal, Pyrichlor PE, Dicomal-PH, Pro-Clear AC, P-Hist, Resperal, Nalfrx, ProHist, Poly Tan, Poly Tan DM, Poly Tan D, Nalex A 12, Tri Tann Pediatric, Url-Tannate Pediatric, Tritan, Tanamine, Rhinatate, Rhinatate Pediatric, Tri-Tannate, Tanamine Pediatric, Tri-Tannate Pediatric, R-Tannamine, URL-Tannate, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Chlorex-A 12, Triotann Pediatric, Histatan, Phena-S, Codal-DM Syrup

Pyrilamine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. One early study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in 3 women, drug levels in milk ranged from 50 to 2.3 mg/L at 1 to 2 hours after the dose and 220 mcg/L to 4 mg/L 5 hours after the dose. Eight hours after the dose, levels were 200 mcg/L and 1.16 mg/L in two mothers, respectively, and not measured in the third.[1] No studies using modern assay methods have been reported.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.[2]

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.

2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Pyrilamine Identification

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Administrative Information

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