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Pyrilamine use while Breastfeeding

Medically reviewed by Last updated on Sep 3, 2023.

Drugs containing Pyrilamine: Midol Complete, Ninjacof, Capron DM, Menstrual Pain Relief, Capron DMT, Midol PMS Maximum Strength, Pamprin Multi-Symptom Menstrual Relief, Resperal, Menstrual PMS, Tanoral, Show all 167 »Premsyn PMS, Pamprin Maximum Pain, Chlorex-A 12, Nalex A 12, AllerTan, Polytine D, Menstrual Relief Extra Strength, Menstrual Relief Maximum Strength, Menstrual Relief, Menstrual Complete, Ninjacof-A, Covangesic, Menstrual Relief Multi-Symptom, Syncol, PMS Formula Multi-Symptom, PMS Relief, HistaFlex, Dermagesic, Z-Xtra, Tussi-12D S, C-Tanna 12D, Tannihist-12D, Tannate 12D S, Tussi-12D, Zotex-D, Corzall Plus, Pyrlex CB, Pro-Chlo, Ninjacof-D, Histalet Forte, Vanex Forte, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Equitan Pediatric, Triple Tannate Pediatric, Tri-Tannate, Tanamine Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tritan, Tanamine, R-Tannamine, URL-Tannate, Triotann, Ru-Hist Forte, Histatan, Phena-S, Triotann Pediatric, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Conal, Pyrichlor PE, Poly Hist PD (old formulation), Phena-S 12, MyHist-PD, Triplex AD, Zotex-C, Codimal PH, Pro-Red AC (old formulation), Dicomal-PH, Neo AC, Pro-Clear AC, Poly Tan DM, Poly Tan D, Poly Tan, Coryza-DM, ProHist, P-Hist, Nalfrx, Codal-DM Syrup, Viravan-DM, V-Tan DM, Zotex-12, Deconsal DM Tannate, Aldex DM, Viratan-DM, Triplex DM, Codimal DM, Codituss DM, Reme Hist DM, Pryil DM, MyHist-DM, Tannate V DM, Ru-Hist Plus, Deconsal DM, Viravan-PDM, Poly Hist DHC, Ryna-12X, A-Tan 12X, Rolatuss with Hydrocodone, Ru-Tuss with Hydrocodone, Vetuss HC Syrup, PhendaCof Plus, Hycomal DH, Dicomal-DH, Hyco-DH, Codal-DH Syrup, Hydrophene DH, Codituss DH, De-Chlor MR, Mintuss MR, Trimal DH, Tussplex, Poly Hist HC, Delhist D, Multihistamine-D, Multihistamine-D Ped, Poly-D, Delhistine D, Poly-Histine-D, Prohistine-D, Metahistine D, Trihist-D, Liqui-Histine-D, KG-Hist D, Iohist D, Histine-D, Uni-Multihist D Ped, Liqui-Minic Infant, Quadra-Hist D Pediatric, Quadra-Hist D, Poly-Histine, Tri-Histine, Myci Spray, Deconsal CT, Viravan-T, K-Tan 4, K-Tan, Ryna-12, Pyril Mal Phenyl HCl, Poly Hist Forte (old formulation), R-Tannic-S A/D, Pyril Tann-12, Viravan-S, V-Tann, Ry-T-12, Deconsal CT Tannate, Aldex D, Rynesa 12S, Pyrlex PD, Ryna-12S, Ru-Hist D (old formulation), Pyril D, Viravan-P, PediaClear 8, Pyrlex

Pyrilamine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.[1]

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2,3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


Ito S, Blajchman A, Stephenson M, et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393–9. [PubMed: 8498418]
Messinis IE, Souvatzoglou A, Fais N, et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143–6. [PubMed: 3928731]
Pontiroli AE, De Castro e Silva E, Mazzoleni F, et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: Sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924–8. [PubMed: 7228996]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding



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Further information

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