Pyrilamine use while Breastfeeding
Drugs containing Pyrilamine: Triplex AD, Tanoral, Midol PMS, Ninjacof, Pamprin Multi-Symptom Menstrual Relief, Menstrual Pain Relief, Pamprin Maximum Pain, Resperal, Midol PMS Maximum Strength, Capron DM, Show all 165 »Triplex DM, Poly-Histine-D, KG-Hist D, Menstrual Complete, Neo AC, Phena-Plus, Ru-Hist Forte, URL-Tannate, Tritan, Triotann-S, Pyril D, Midol Maximum Strength Menstrual, Tussi-12D, Dermagesic, Tussi-12D S, Trimal DH, Codal-DH Syrup, Hydrophene DH, Codituss DH, De-Chlor MR, Mintuss MR, Tussplex, Dicomal-DH, Poly Hist HC, Menstrual Relief, Menstrual Relief Maximum Strength, Delhist D, Multihistamine-D, Multihistamine-D Ped, Hyco-DH, PhendaCof Plus, Hycomal DH, Viravan-PDM, Reme Hist DM, Pryil DM, MyHist-DM, Tannate V DM, Ru-Hist Plus, Deconsal DM, Ninjacof-A, Delhistine D, Poly Hist DHC, Ryna-12X, A-Tan 12X, Rolatuss with Hydrocodone, Ru-Tuss with Hydrocodone, Vetuss HC Syrup, Poly-D, Metahistine D, Prohistine-D, Ry-T-12, Pyril Mal Phenyl HCl, Poly Hist Forte (old formulation), R-Tannic-S A/D, Pyril Tann-12, Viravan-S, V-Tann, Deconsal CT Tannate, K-Tan, Aldex D, Rynesa 12S, Pyrlex PD, Ryna-12S, Ru-Hist D (old formulation), Viravan-P, Ryna-12, K-Tan 4, Codimal DM, Liqui-Minic Infant, Polytine D, Trihist-D, Liqui-Histine-D, Iohist D, Histine-D, Uni-Multihist D Ped, Quadra-Hist D Pediatric, Viravan-T, Quadra-Hist D, Poly-Histine, Tri-Histine, Myci Spray, Menstrual Relief Extra Strength, Deconsal CT, Codituss DM, Aldex DM, Viratan-DM, R-Tannate Pediatric, Tanamine, Url-Tannate Pediatric, Rhinatate, Rhinatate Pediatric, Tri-Tannate Pediatric, Tanamine Pediatric, Tri-Tannate, Triple Tannate Pediatric, Equitan Pediatric, Tanoral Pediatric, Triotann-S Pediatric, R-Tannamine Pediatric, R-Tannate, Gelhist Pediatric, Rynatan-S Pediatric, Triotann, Histalet Forte, Tannihist-12D, Tannate 12D S, Zotex-D, Corzall Plus, Pyrlex CB, Pro-Chlo, Vanex Forte, Atrohist Pediatric, Z-Xtra, HistaFlex, PMS Relief, PMS Formula Multi-Symptom, Syncol, Menstrual PMS, R-Tannamine, Histatan, C-Tanna 12D, P-Hist, Poly Tan DM, Poly Tan D, Poly Tan, Premsyn PMS, Coryza-DM, ProHist, Nalfrx, Menstrual Relief Multi-Symptom, Covangesic, Codal-DM Syrup, Viravan-DM, V-Tan DM, Zotex-12, Deconsal DM Tannate, Pro-Clear AC, Dicomal-PH, Phena-S, AllerTan, Triotann Pediatric, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Tri Tann Pediatric, Nalex A 12, Conal, Pro-Red AC (old formulation), Pyrichlor PE, Poly Hist PD (old formulation), Phena-S 12, MyHist-PD, Zotex-C, Codimal PH, Pyrlex
Pyrilamine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. One early study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in 3 women, drug levels in milk ranged from 50 to 2.3 mg/L at 1 to 2 hours after the dose and 220 mcg/L to 4 mg/L 5 hours after the dose. Eight hours after the dose, levels were 200 mcg/L and 1.16 mg/L in two mothers, respectively, and not measured in the third. No studies using modern assay methods have been reported.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.
Effects on Lactation and Breastmilk
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.
Alternate Drugs to Consider
1. Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.
2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
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