Skip to Content

Pyrilamine use while Breastfeeding

Drugs containing Pyrilamine: Midol PMS, Capron DM, Triplex DM, Tanoral, Poly Hist Forte (old formulation), Pyril D, Midol Maximum Strength Menstrual, Triplex AD, Poly-Histine-D, Neo AC, Show all 165 »Codituss DM, Poly-Histine, Triotann, Ninjacof, HistaFlex, Menstrual Pain Relief, Pamprin Multi-Symptom Menstrual Relief, Pamprin Maximum Pain, Midol PMS Maximum Strength, Codimal DM, Menstrual Relief Maximum Strength, Ru-Tuss with Hydrocodone, Poly Hist HC, Vetuss HC Syrup, Tussplex, PhendaCof Plus, Hydrophene DH, Rolatuss with Hydrocodone, Codituss DH, De-Chlor MR, Trimal DH, Codal-DH Syrup, Hycomal DH, Dicomal-DH, Hyco-DH, Mintuss MR, Poly Hist DHC, Viratan-DM, Reme Hist DM, Aldex DM, Deconsal DM Tannate, V-Tan DM, Zotex-12, Pryil DM, MyHist-DM, Delhist D, Ryna-12X, Viravan-PDM, Deconsal DM, Tannate V DM, Ru-Hist Plus, A-Tan 12X, Trihist-D, Pyril Tann-12, Viravan-S, V-Tann, R-Tannic-S A/D, Pyril Mal Phenyl HCl, K-Tan 4, K-Tan, Ryna-12, Ry-T-12, Deconsal CT Tannate, Ru-Hist D (old formulation), Viravan-P, Pyrlex, Ryna-12S, Pyrlex PD, Aldex D, Rynesa 12S, Viravan-T, Deconsal CT, Polytine D, Viravan-DM, Liqui-Histine-D, Metahistine D, Prohistine-D, Multihistamine-D Ped, Poly-D, Delhistine D, KG-Hist D, Iohist D, Quadra-Hist D, Tri-Histine, Myci Spray, Quadra-Hist D Pediatric, Liqui-Minic Infant, Histine-D, Uni-Multihist D Ped, Multihistamine-D, Coryza-DM, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Vanex Forte, Histalet Forte, Corzall Plus, Pyrlex CB, Pro-Chlo, Gelhist Pediatric, R-Tannate, Equitan Pediatric, Triple Tannate Pediatric, Tri-Tannate, Tanoral Pediatric, Triotann-S Pediatric, Triotann-S, R-Tannamine Pediatric, Zotex-D, Tussi-12D, Premsyn PMS, Menstrual Relief Multi-Symptom, Menstrual PMS, Covangesic, Ninjacof-A, Menstrual Relief Extra Strength, Menstrual Relief, Menstrual Complete, Syncol, PMS Formula Multi-Symptom, C-Tanna 12D, Tannihist-12D, Tannate 12D S, Tussi-12D S, Z-Xtra, PMS Relief, Dermagesic, Tanamine Pediatric, Tri-Tannate Pediatric, Zotex-C, Codimal PH, Pro-Red AC (old formulation), MyHist-PD, Phena-S 12, Conal, Pyrichlor PE, Poly Hist PD (old formulation), Dicomal-PH, Pro-Clear AC, P-Hist, Resperal, Nalfrx, ProHist, Poly Tan, Poly Tan DM, Poly Tan D, AllerTan, Nalex A 12, Tanamine, R-Tannamine, URL-Tannate, Tritan, Url-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Ru-Hist Forte, Histatan, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Tri-Gestan S, Chlorex-A 12, Phena-S, Triotann Pediatric, Codal-DM Syrup

Pyrilamine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. One early study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in 3 women, drug levels in milk ranged from 50 to 2.3 mg/L at 1 to 2 hours after the dose and 220 mcg/L to 4 mg/L 5 hours after the dose. Eight hours after the dose, levels were 200 mcg/L and 1.16 mg/L in two mothers, respectively, and not measured in the third.[1] No studies using modern assay methods have been reported.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.[2]

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.

2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Pyrilamine Identification

Substance Name


CAS Registry Number


Drug Class


Administrative Information

LactMed Record Number


Last Revision Date



Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.