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Pyrilamine use while Breastfeeding

Drugs containing Pyrilamine: Midol Complete, Midol PMS Maximum Strength, Pamprin Multi-Symptom Menstrual Relief, Capron DM, Menstrual Pain Relief, Capron DMT, Aldex D, Ninjacof, PMS Relief, Codimal DM, Show all 166 »Histine-D, Resperal, AllerTan, Aldex DM, Tanoral, Viratan-DM, Menstrual Relief, De-Chlor MR, Codituss DH, Hydrophene DH, Mintuss MR, Ryna-12X, Hyco-DH, Dicomal-DH, Hycomal DH, PhendaCof Plus, Vetuss HC Syrup, Ru-Tuss with Hydrocodone, Rolatuss with Hydrocodone, A-Tan 12X, Codal-DH Syrup, Pyril D, Poly Hist DHC, Codituss DM, Codal-DM Syrup, Viravan-DM, V-Tan DM, Zotex-12, Deconsal DM Tannate, Triplex DM, Reme Hist DM, Tussplex, Pryil DM, MyHist-DM, Tannate V DM, Ru-Hist Plus, Deconsal DM, Viravan-PDM, Viravan-P, Trimal DH, Pyrlex PD, Poly Hist HC, Ryna-12, Myci Spray, Ryna-12S, Deconsal CT, Viravan-T, K-Tan 4, K-Tan, Pyril Mal Phenyl HCl, Poly-Histine, Poly Hist Forte (old formulation), R-Tannic-S A/D, Pyril Tann-12, Viravan-S, V-Tann, Ry-T-12, Deconsal CT Tannate, Tri-Histine, Quadra-Hist D, Rynesa 12S, Metahistine D, Delhist D, Multihistamine-D, Multihistamine-D Ped, Poly-D, Poly-Histine-D, Prohistine-D, Polytine D, Ru-Hist D (old formulation), Trihist-D, Liqui-Histine-D, KG-Hist D, Iohist D, Uni-Multihist D Ped, Liqui-Minic Infant, Quadra-Hist D Pediatric, Delhistine D, Coryza-DM, Nalfrx, Atrohist Pediatric, Corzall Plus, Pyrlex CB, Pro-Chlo, Ninjacof-D, Histalet Forte, Vanex Forte, Rynatan-S Pediatric, Tussi-12D, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Zotex-D, Tannate 12D S, Triple Tannate Pediatric, Menstrual Relief Multi-Symptom, Menstrual Relief Extra Strength, Menstrual Relief Maximum Strength, Menstrual Complete, Ninjacof-A, Covangesic, Premsyn PMS, Pamprin Maximum Pain, Menstrual PMS, Tannihist-12D, Syncol, PMS Formula Multi-Symptom, HistaFlex, Dermagesic, Z-Xtra, Tussi-12D S, C-Tanna 12D, Equitan Pediatric, Tri-Tannate, P-Hist, Codimal PH, Pyrichlor PE, Poly Hist PD (old formulation), Phena-S 12, MyHist-PD, Triplex AD, Zotex-C, Pro-Red AC (old formulation), Nalex A 12, Dicomal-PH, Neo AC, Pro-Clear AC, Poly Tan DM, Poly Tan D, Poly Tan, ProHist, Conal, Tri Tann Pediatric, Tanamine Pediatric, URL-Tannate, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tritan, Tanamine, R-Tannamine, Triotann, Phena-Plus, Ru-Hist Forte, Histatan, Phena-S, Triotann Pediatric, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Pyrlex

Medically reviewed by Last updated on Feb 2, 2021.

Pyrilamine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. One early study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in 3 women, drug levels in milk ranged from 50 to 2.3 mg/L at 1 to 2 hours after the dose and 220 mcg/L to 4 mg/L 5 hours after the dose. Eight hours after the dose, levels were 200 mcg/L and 1.16 mg/L in two mothers, respectively, and not measured in the third.[1] No studies using modern assay methods have been reported.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.[2]

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.
Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. [PubMed: 8498418]
Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. [PubMed: 3928731]
Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. [PubMed: 7228996]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

  • Breast Feeding
  • Lactation
  • Antihistamines

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