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Granisetron use while Breastfeeding

Medically reviewed by Last updated on Oct 11, 2023.

Drugs containing Granisetron: Kytril, Sancuso, Sustol, Granisol

Granisetron Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the use of granisetron during breastfeeding. Until more data become available, granisetron should be used with caution during breastfeeding. An alternate drug may be preferred.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

A woman nursing an 8-month-old infant 6 to 8 times daily was admitted to the hospital for an appendectomy. During the procedure she received granisetron, cefazolin, ketorolac, rocuronium, succinylcholine, and sufentanil. The patient also received 2 boluses of intravenous propofol of 150 mg followed shortly thereafter by a 50 mg dose. Postoperatively, she was receiving acetaminophen, cefazolin, ibuprofen, and pantoprazole, as well as oxycodone and dimenhydrinate as needed. Twenty-two hours after the procedure, the mother extracted milk for the first time and noted it to be light green in color. Analysis of the green milk using a nonvalidated assay detected no propofol. The green color faded and was absent by postoperative day 4 when she resumed breastfeeding. The authors judged that the green color was possibly caused by propofol or one of its metabolites.[1]

Alternate Drugs to Consider



Rainone A, Delucilla L, Elofer S, et al. Propofol-induced green breast milk: A case report. Can J Hosp Pharm. 2018;71:389–91. [PMC free article: PMC6306180] [PubMed: 30626986]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding



Gastrointestinal Agents

Serotonin Antagonists

Serotonin 5-HT3 Receptor Antagonists

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Further information

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