Fluphenazine use while Breastfeeding
Medically reviewed by Drugs.com. Last updated on Feb 21, 2022.
Drugs containing Fluphenazine: Prolixin, Prolixin Decanoate, Permitil, Prolixin Enanthate
Fluphenazine Levels and Effects while Breastfeeding
Summary of Use during Lactation
There is no published experience with fluphenazine during breastfeeding. Very limited long-term follow-up data indicate no adverse developmental effects when other phenothiazines are used alone. Because of the lack of published experience with fluphenazine during breastfeeding, other antipsychotic agents may be preferred, especially while nursing a newborn or preterm infant. Monitor the infant for drowsiness and developmental milestones, especially if other antipsychotics are used concurrently.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Phenothiazines cause galactorrhea in 26 to 40% of female patients.[1,2] Hyperprolactinemia appears to be the cause of the galactorrhea.[3-6] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.
Like other phenothiazines, fluphenazine elevates serum prolactin and has caused galactorrhea. The elevation is related to serum levels and lasts 2 to 4 weeks with the depot injectable formulation.[2,8] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.
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Hooper JH Jr, Welch VC, Shackelford RT. Abnormal lactation associated with tranquilizing drug therapy. JAMA. 1961;178:506–7. [PubMed: 14448766]
Turkington RW. Prolactin secretion in patients treated with various drugs: phenothiazines, tricyclic antidepressants, reserpine, and methyldopa. Arch Intern Med. 1972;130:349–54. [PubMed: 4560178]
Turkington RW. Serum prolactin levels in patients with gynecomastia. J Clin Endocrinol Metab. 1972;34:62–6. [PubMed: 5061776]
Beumont PJ, Gelder MG, Friesen HG, et al. The effects of phenothiazine on endrocrine function: I Patients with inappropriate lactation and amenorrhoea. Br J Psychiatry. 1974;124:413–9. [PubMed: 4151788]
Meltzer HY, Fang VS. The effect of neuroleptics on serum prolactin in schizophrenic patients. Arch Gen Psychiatry. 1976;33:279–86. [PubMed: 1259521]
Maguire GA. Prolactin elevation with antipsychotic medications: Mechanisms of action and clinical consequences. J Clin Psychiatry. 2002;63 Suppl 4:56–62. [PubMed: 11913677]
Meltzer HY, Fang VS, Goode DJ. Prolactin and neuroleptics: Clinical implications for efficacy and toxicity. The effect of neuroleptics and alpha-methyl-para-tyrosine on serum prolactin levels in laboratory animals and man. Psychopharmacol Bull. 1978;14:5–7. [PubMed: 625539]
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