Estradiol Cypionate use while Breastfeeding
Drugs containing Estradiol Cypionate: Estrace, CombiPatch, Vagifem, Estradiol Patch, Progynova, Yuvafem, Estring, Imvexxy, Estrace Vaginal Cream, Oriahnn, Show all 116 »Climara, Divigel, Vivelle-Dot, Estrogel, Minivelle, Natazia, Depo-Estradiol, Dotti, Myfembree, Activella, Bijuva, Lyllana, Angeliq, Vivelle, Evamist, Estrogen Patches, Delestrogen, Evorel, Oestradiol Implants, Climara Pro, Mimvey, Amabelz, Femring, Estradot, Estrofem, Estreva, Estraderm, Alora, Oesclim, Oestrogel Pump-Pack, Progynova TS, Sandrena, Zumenon, Fematrix, Climaval, Menorest, Oestrogel, Elestrin, Menostar, Lunelle, Ena, Lopreeza, Prefest, Valergen, Depogen, Dep Gynogen, Gynogen LA 20, Dioval 40, Dioval XX, Duragen, Estra-C, Estra-V 40, Estro-Cyp, Gynodiol, Estro-Span 40, Medidiol 10, Dura-Estrin, Fempatch, Esclim, Estragyn LA 5, Clinagen LA 40, Estro-LA, Menaval-20, Estradot 37.5, Estradot 50, Estradot 75, Estradot 100, Dermestril, FemSeven, Aerodiol, Elleste Solo, Adgyn Estro, FemSeven Sequi Phase I, Menorest Patch, Nuvelle TS Phase I, FemTab, Estrasorb, Femtran, Primogyn Depot, Climodien, Organon Oestradiol, Bedol, Delidose, Dermestril Septem, Estradiol G GAM, Estrapatch, Femsept, Oestrodose, Oromone, Provames, Systen, Thais, Thaissept, Estra Pellets, Femtrace, Mimvey Lo, Ortho-Prefest, Depo-Testadiol, Depotestogen, Dep Androgyn, Delatestadiol, Estra-Testrin, Valertest No 1, Duo-Cyp, Dura-Dumone, Duratestrin
Medically reviewed by Drugs.com. Last updated on May 15, 2021.
Estradiol Cypionate Levels and Effects while Breastfeeding
Summary of Use during Lactation
Estradiol cypionate has not been studied during breastfeeding. However, the similar drug, estradiol valerate, has been used to suppress lactation, usually in combination with testosterone. Generally, estradiol cypionate should be avoided in mothers wishing to breastfeed.
Maternal Levels. Relevant published information on estradiol cypionate was not found as of the revision date. However, estradiol appears in breastmilk in small amounts after administration by other routes.[1,2]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Another injection ester form of estradiol, estradiol valerate was previously used therapeutically to suppress lactation, usually in combination with testosterone.[3-5]
A retrospective cohort study compared 371 women who received high-dose estrogen (either 3 mg of diethylstilbestrol or 150 mcg of ethinyl estradiol daily) during adolescence for adult height reduction to 409 women who did not receive estrogen. No difference in breastfeeding duration was found between the two groups, indicating that high-dose estrogen during adolescence has no effect on later breastfeeding.
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Nilsson S, Nygren KG, Johansson ED. Transfer of estradiol to human milk. Am J Obstet Gynecol. 1978;132:653–7. [PubMed: 717472]
Perheentupa A, Critchley HO, Illingworth PJ, et al. Enhanced sensitivity to steroid-negative feedback during breast-feeding: Low-dose estradiol (transdermal estradiol supplementation) suppresses gonadotropins and ovarian activity assessed by inhibin B. J Clin Endocrinol Metab. 2000;85:4280–6. [PubMed: 11095468]
Louviere RL, Upton RT. Evaluation of Deladumone OB in the suppression of postpartum lactation. Am J Obstet Gynecol. 1975;121:641–2. [PubMed: 1090174]
Morris JA, Creasy RK, Hohe PT. Inhibition of puerperal lactation. Double-blind comparison of chlorotrianesene, testosterone enanthate with estradiol valerate and placebo. Obstet Gynecol. 1970;36:107–14. [PubMed: 4912251]
Iliya FA, Safon L, O'Leary JA. Testosterone enanthate (180 mg.) and estradiol valerate (8 mg.) for suppression of lactation: A double-blind evaluation. Obstet Gynecol. 1966;27:643–5. [PubMed: 5949195]
Jordan HL, Bruinsma FJ, Thomson RJ, et al. Adolescent exposure to high-dose estrogen and subsequent effects on lactation. Reprod Toxicol. 2007;24:397–402. [PubMed: 17531440]
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