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Estradiol Cypionate use while Breastfeeding

Drugs containing Estradiol Cypionate: Estrace, Vagifem, Estradiol Patch, Estrace Vaginal Cream, Vivelle, Vivelle-Dot, Estring, Estrogel, Yuvafem, Climara, Show all 109 »Minivelle, Mimvey, Elestrin, Evamist, CombiPatch, Activella, Depo-Estradiol, Divigel, Estradot, Estrogen Patches, Natazia, Alora, Lopreeza, Estraderm, Angeliq, Climara Pro, Progynova, Femring, Estrofem, Delestrogen, Mimvey Lo, Amabelz, Zumenon, Systen, Menostar, Prefest, Femtrace, Provames, Sandrena, Fematrix, Estrasorb, Estradiol G GAM, Evorel, Medidiol 10, Depogen, Dioval 40, Gynodiol, Estro-Span 40, Oestrogel, FemSeven, Oestrodose, Oromone, Thais, Thaissept, Menorest, Femsept, Delidose, Dermestril Septem, Estrapatch, Estreva, Dura-Dumone, Duo-Cyp, Depotestogen, Depo-Testadiol, Ortho-Prefest, Oestradiol Implants, Duratestrin, Dep Androgyn, Valertest No 1, Estra-Testrin, Delatestadiol, Lunelle, Ena, Estradot 37.5, Estragyn LA 5, Esclim, Fempatch, Oesclim, Clinagen LA 40, Menaval-20, Estro-LA, Dura-Estrin, Estro-Cyp, Gynogen LA 20, Dep Gynogen, Valergen, Dioval XX, Duragen, Estra-V 40, Estra-C, Estradot 50, Estradot 75, FemTab, Climaval, Nuvelle TS Phase I, Femtran, Primogyn Depot, Organon Oestradiol, Climodien, Menorest Patch, FemSeven Sequi Phase I, Dermestril, Oestrogel Pump-Pack, Estradot 100, Progynova TS, Aerodiol, Adgyn Estro, Elleste Solo, Bedol

Estradiol Cypionate Levels and Effects while Breastfeeding

Summary of Use during Lactation

Estradiol cypionate has not been studied during breastfeeding. However, the similar drug, estradiol valerate, has been used to suppress lactation, usually in combination with testosterone. Generally, estradiol cypionate should be avoided in mothers wishing to breastfeed.

Drug Levels

Maternal Levels. Relevant published information on estradiol cypionate was not found as of the revision date. However, estradiol appears in breastmilk in small amounts after administration by other routes.[1][2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Another injection ester form of estradiol, estradiol valerate was previously used therapeutically to suppress lactation, usually in combination with testosterone.[3][4][5]

A retrospective cohort study compared 371 women who received high-dose estrogen (either 3 mg of diethylstilbestrol or 150 mcg of ethinyl estradiol daily) during adolescence for adult height reduction to 409 women who did not receive estrogen. No difference in breastfeeding duration was found between the two groups, indicating that high-dose estrogen during adolescence has no effect on later breastfeeding.[6]

Alternate Drugs to Consider

Ethinyl Estradiol


1. Nilsson S, Nygren KG, Johansson ED. Transfer of estradiol to human milk. Am J Obstet Gynecol. 1978;132:653-7. PMID: 717472

2. Perheentupa A, Critchley HO, Illingworth PJ, McNeilley AS. Enhanced sensitivity to steroid-negative feedback during breast-feeding: low-dose estradiol (transdermal estradiol supplementation) suppresses gonadotropins and ovarian activity assessed by inhibin B. J Clin Endocrinol Metab. 2000;85:4280-6. PMID: 11095468

3. Louviere RL, Upton RT. Evaluation of Deladumone OB in the suppression of postpartum lactation. Am J Obstet Gynecol. 1975;121:641-2. PMID: 1090174

4. Morris JA, Creasy RK, Hohe PT. Inhibition of puerperal lactation. Double-blind comparison of chlorotrianesene, testosterone enanthate with estradiol valerate and placebo. Obstet Gynecol. 1970;36:107-14. PMID: 4912251

5. Iliya FA, Safon L, O'Leary JA. Testosterone enanthate (180 mg.) and estradiol valerate (8 mg.) for suppression of lactation: a double-blind evaluation. Obstet Gynecol. 1966;27:643-5. PMID: 5949195

6. Jordan HL, Bruinsma FJ, Thomson RJ et al. Adolescent exposure to high-dose estrogen and subsequent effects on lactation. Reprod Toxicol. 2007;24:397-402. PMID: 17531440

Estradiol Cypionate Identification

Substance Name

Estradiol Cypionate

CAS Registry Number


Drug Class



Administrative Information

LactMed Record Number


Last Revision Date



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