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How does Wellbutrin work in a brain?


WildcatVet 27 Aug 2021

Hi, Tsuto!
This answer is from Medical News Today:
"Most antidepressants are selective serotonin reuptake inhibitor (SSRI). They boost the levels of serotonin in the brain.
Bupropion, or Wellbutrin, is different. It is a norepinephrine-dopamine reuptake inhibitor (NDRI).
An NDRI boosts levels of the neurotransmitters norepinephrine, also known as noradrenaline, and dopamine.
Its action is complex, and its neurological effects are only partly understood.
As well as being an antidepressant, bupropion is an antagonist at nicotinic receptors. This means that it blocks receptors where nicotine normally binds, making it useful in smoking cessation."
Best regards,

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