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Related terms: Ekbom Disease, RLS, Willis-Ekbom Disease, Restless Leg

New Genes Linked to Restless Legs Syndrome

Posted 18 Oct 2017 by Drugs.com

WEDNESDAY, Oct. 18, 2017 – Scientists have pinpointed more gene mutations that may cause restless legs syndrome. A new study involving roughly 46,000 people with restless legs syndrome turned up 13 new gene variants that appear to raise the risk for the condition, which affects up to 10 percent of the U.S. and European populations. "We were able to identify a total of 19 risk-associated genetic variants, of which 13 are new. We're confident that our findings will significantly improve our understanding of the molecular causes of restless legs syndrome," said study first author Dr. Barbara Schormair. She's with the Institute of Neurogenomics at the Helmholtz Center in Munich, Germany. People with the condition experience unpleasant sensations in their legs at night, including tingling and the urge to move their legs. For the study, an international team of researchers from the Technical ... Read more

Related support groups: Restless Legs Syndrome, Periodic Limb Movement Disorder, Thalidomide, Thalomid

Frequent Blood Donations Safe for Some, But Not All

Posted 21 Sep 2017 by Drugs.com

THURSDAY, Sept. 21, 2017 – Some people may safely donate blood as often as every eight weeks – but that may not be a healthy choice for all, a new study suggests. The study was done in the United Kingdom, where experts recommend that blood donors wait 12 to 16 weeks before giving again. That's in contrast to the United States, where blood donations are already allowed at eight-week intervals. The study – a large clinical trial involving more than 45,000 blood donors – was set up to answer a critical question: Do frequent donors suffer ill health effects? The answer, researchers found, was "nuanced." There was no evidence that frequent donations caused "major adverse effects," such as draining donors' physical energy, dimming their mental sharpness or harming their general quality of life. "Frequent," in this trial, meant every eight weeks for men and every 12 weeks for women, over ... Read more

Related support groups: Fatigue, Restless Legs Syndrome, Anemia, Iron Deficiency Anemia, Blood Transfusion, Blood Cell Transplantation

Living With Purpose May Help Seniors Sleep Soundly

Posted 10 Jul 2017 by Drugs.com

MONDAY, July 10, 2017 – Seniors who believe they have a purpose in life may sleep better, researchers say. Those who have good reasons to get up every day are less apt to have problems that keep them awake at night, such as sleep apnea and restless leg syndrome, according to a new study. People tend to have more trouble sleeping as they age, the researchers added. "Helping people cultivate a purpose in life could be an effective drug-free strategy to improve sleep quality, particularly for a population that is facing more insomnia," said study senior author Jason Ong. He's an associate professor of neurology at Northwestern University's Feinberg School of Medicine in Chicago. The study included more than 800 people between the ages of 60 and 100 who did not have dementia. Those who said their lives had meaning were 63 percent less likely to have sleep apnea and 52 percent less likely ... Read more

Related support groups: Sleep Disorders, Insomnia, Fatigue, Restless Legs Syndrome, Dementia, Alzheimer's Disease, Sleep Apnea, Periodic Limb Movement Disorder, Mild Cognitive Impairment, Obstructive Sleep Apnea/Hypopnea Syndrome, Shift Work Sleep Disorder

Better Sleep Could Mean Better Sex for Older Women

Posted 1 Feb 2017 by Drugs.com

WEDNESDAY, Feb. 1, 2017 – A more satisfying sex life may be only a good night's sleep away for women over 50, new research finds. Researchers led by Dr. Juliana Kling of the Mayo Clinic in Scottsdale, Ariz., tracked data from nearly 94,000 women aged 50 to 79. The investigators found that 31 percent had insomnia, and a little more than half (56 percent) said they were somewhat or very satisfied with their sex life. But too little sleep – fewer than seven to eight hours a night – was linked with a lower likelihood of sexual satisfaction, the findings showed. "This is a very important study since it examines a question which has tremendous potential impact on women's lives," said Dr. Jill Rabin, who reviewed the findings. She's co-chief of the Women's Health Program at Northwell Health in New Hyde Park, N.Y. Age played a key role in outcomes. For example, the study found that older ... Read more

Related support groups: Anxiety, Generalized Anxiety Disorder, Xanax, Anxiety and Stress, Sleep Disorders, Klonopin, Insomnia, Clonazepam, Ativan, Valium, Fatigue, Hot Flashes, Lorazepam, Restless Legs Syndrome, Alprazolam, Diazepam, Menopausal Disorders, Temazepam, Postmenopausal Symptoms, Librium

Study Finds Genetic Link Between Sleep Problems and Obesity

Posted 19 Dec 2016 by Drugs.com

MONDAY, Dec. 19, 2016 – There seems to be a genetic link between poor sleep and some medical conditions, including obesity, restless legs syndrome and schizophrenia, researchers report. "This clinical science is an important step forwards in understanding the biological basis for these conditions, so it's very exciting," said study co-author Dr. Martin Rutter. He is senior lecturer in cardiometabolic medicine at the University of Manchester in England. "Scientists have long observed a connection between sleep disorders and these conditions in epidemiological studies. But this is the first time these biological links have been identified at a molecular level," Rutter said. The researchers, from the University of Manchester and Massachusetts General Hospital in Boston, examined the mapped genes of more than 112,000 people in search of links between the participants' genes and their ... Read more

Related support groups: Obesity, Restless Legs Syndrome, Schizophrenia, Schizoaffective Disorder, Periodic Limb Movement Disorder, Diagnosis and Investigation

Health Tip: Do You Have Restless Legs Syndrome?

Posted 4 Jan 2016 by Drugs.com

-- Restless legs syndrome (RLS) is a nervous system disorder that's characterized by an itchy twitching of the legs during rest that's relieved by moving them. The National Heart, Lung, and Blood Institute says typical symptoms include: Feeling a crawling, tingling, burning, aching, pulling or itching sensation in the legs. Having the urge to move worsens when you are still. Walking and other types of movement alleviate the urge. Having symptoms that worsen late in the day. Read more

Related support groups: Restless Legs Syndrome, Periodic Limb Movement Disorder

Health Tip: What's Behind Muscle Cramps?

Posted 28 Oct 2015 by Drugs.com

-- Nothing can end a workout faster than muscle cramps. But have you ever wondered what causes them? The Mayo Clinic mentions these common factors: Straining or overusing muscles. Being dehydrated. Keeping a muscle in the same position for a long time. Having poor blood supply to affected muscles. Having compressed nerves in the spine. Getting less-than-required amounts of dietary minerals, such as potassium, magnesium or calcium. Read more

Related support groups: Muscle Spasm, Muscle Pain, Restless Legs Syndrome, Dietary Supplementation, Vitamin/Mineral Supplementation and Deficiency, Periodic Limb Movement Disorder, Nocturnal Leg Cramps, Potassium Chloride, Muscle Twitching, Klor-Con, K + Potassium, Klor-Con M20, Caltrate 600 with D, Klor-Con M10, K-Tab, Micro-K 10, Calcium/Vitamin D, Os-Cal 500 with D, K-10, Micro-K

New Drug Shows Promise for Restless Legs Syndrome: Study

Posted 12 Feb 2014 by Drugs.com

WEDNESDAY, Feb. 12, 2014 – For relieving symptoms of restless legs syndrome and slowing its progression, the drug pregabalin (Lyrica) outperformed the current standard medication in a head-to-head comparison, a new study found. Pramipexole (Mirapex), which is commonly used to treat this neurological disease, makes many people worse, said lead researcher Richard Allen, an associate professor of neurology at Johns Hopkins University School of Medicine in Baltimore. Lyrica works just as well and doesn't worsen the condition, Allen said. People with restless legs syndrome – now also known as Willis-Ekbom disease – feel throbbing, creeping or other unpleasant sensations in the legs and an uncontrollable urge to move them. Symptoms occur primarily at night, and most people with restless legs syndrome have trouble falling asleep and staying asleep. Moving the legs relieves the discomfort; ... Read more

Related support groups: Lyrica, Restless Legs Syndrome, Pregabalin

Restless Legs Syndrome Tied to Earlier Death Risk

Posted 12 Jun 2013 by Drugs.com

WEDNESDAY, June 12 – Men with restless legs syndrome now have another health concern: New research has just linked the condition to an increased risk of dying early. In a study of nearly 20,000 men, Harvard researchers found that men with restless legs syndrome had a 39 percent higher risk of an early death than did men without the condition. "This study suggests that individuals with restless legs syndrome are more likely to die early than other people," said study author Dr. Xiang Gao, an assistant professor at Harvard Medical School and an associate epidemiologist at Brigham and Women's Hospital in Boston. "This association was independent of other known risk factors." "[However], this is an observational study," Gao said of the findings, which were published online June 12 in the journal Neurology. "We can only see an association that suggests a possible causal relationship." ... Read more

Related support groups: Restless Legs Syndrome

Drugs May Help Relieve Restless Legs Syndrome

Posted 4 Mar 2013 by Drugs.com

MONDAY, March 4 – People suffering from restless legs syndrome may find some relief by taking one of several drugs approved to treat the condition, a new review confirms. The medications, which include Requip (ropinirole), levodopa, Neurontin (gabapentin) and Lyrica (pregabalin), appear to reduce symptoms of the syndrome in more than 60 percent of patients, researchers report. The first two drugs raise dopamine levels in the body, and the last two drugs reduce the amount of calcium reaching brain cells and trigger the production of other chemicals that help reduce pain. Dopamine is a brain chemical that regulates movement and mood. "Physicians and patients now have better information on the effectiveness and harms of two types of drug treatments for patients with at least moderately severe restless legs symptoms in which to guide treatment choices," said review author Dr. Timothy Wilt, ... Read more

Related support groups: Gabapentin, Lyrica, Restless Legs Syndrome, Neurontin, Pregabalin, Requip, Ropinirole, Levodopa, Gralise, Horizant, Requip XL, Requip Starter Kit, Gabarone, Repreve, ReQuip Follow on Pack, Dopar, ReQuip Starter Pack, Larodopa, Fanatrex

FDA Medwatch Alert: Mirapex (pramipexole): Drug Safety Communication - Ongoing Safety Review, Possible Risk of Heart Failure

Posted 19 Sep 2012 by Drugs.com

ISSUE: FDA notified healthcare profesionals about a possible increased risk of heart failure with Mirapex (pramipexole). Results of recent studies suggest a potential risk of heart failure that needs further review of available data. Because of the study limitations, FDA is not able to determine whether Mirapex increases the risk of heart failure. FDA is continuing to work with the manufacturer to clarify further the risk of heart failure with Mirapex and will update the public when more information is available. FDA evaluated a pooled analysis of randomized clinical trials and found that heart failure was more frequent with Mirapex than with placebo; however, these results were not statistically significant. FDA also evaluated two epidemiologic studies that suggested an increased risk of new onset of heart failure with Mirapex use. However, study limitations make it difficult to ... Read more

Related support groups: Restless Legs Syndrome, Parkinson's Disease, Mirapex, Pramipexole

Drug Patch Approved for Advanced Parkinson's and Restless Leg Syndrome

Posted 3 Apr 2012 by Drugs.com

TUESDAY, April 3 – The Neupro (rotigotine) transdermal system has been approved by the U.S. Food and Drug Administration to treat advanced Parkinson's disease and moderate-to-severe restless leg syndrome, the Belgian drug maker UCB said Tuesday in a news release. The continuous drug delivery patch was first approved by the FDA in 2007 to treat early-stage Parkinson's. The dopamine agonist skin patch is believed to work by stimulating dopamine receptors within the caudate-putamen, the portion of the brain that regulates movement, the company said. In clinical testing, observed side effects of Neupro included nausea, vomiting, skin site reactions, dizziness, insomnia and headache. Neupro contains sodium metabisulfite, which could cause deadly allergic-like reactions in certain susceptible people. Also, the drug should not be used by pregnant women, UCB warned. More information To learn ... Read more

Related support groups: Restless Legs Syndrome, Parkinson's Disease, Neupro, Rotigotine

Classic Restless Legs Syndrome Not Linked to Parkinson's

Posted 10 Nov 2011 by Drugs.com

THURSDAY, Nov. 10 – People with early Parkinson's disease are not more likely to have restless legs syndrome, but many people with Parkinson's do report leg motor restlessness, according to the results of a new Norwegian study. People with restless legs syndrome, or RLS, have an overwhelming urge to move their legs. This typically occurs at night during rest, and the sensation is relieved by movement. By contrast, leg motor restlessness is characterized by the urge to move the legs throughout the day, and this sensation does not improve with movement. Both RLS and Parkinson's disease, which is a chronic and progressive movement disorder that affects nearly 1 million people in the United States, do respond to the same drugs, but that is where their connection ends. Medications that boost levels of the brain chemical dopamine treat both conditions. To better understand the relationship ... Read more

Related support groups: Restless Legs Syndrome

Restless Legs Syndrome May Boost Blood Pressure

Posted 10 Oct 2011 by Drugs.com

MONDAY, Oct. 10 – Middle-aged women who suffer from a common condition called restless legs syndrome may be at increased risk of high blood pressure, U.S. researchers report. Restless legs syndrome is a sensory motor disorder that causes intense, unpleasant leg sensations, and an irresistible urge to move the legs, often at night. The condition, which may affect between 5 to 15 percent of U.S. adults, can disrupt sleep and cause daytime drowsiness. "For those who experience restless legs syndrome symptoms, please consult your doctor regarding this issue," said lead researcher Dr. Xiang Gao, an assistant professor of medicine at the Harvard Medical School. "The risk of hypertension can be substantially reduced by following a healthy life style, including a healthy diet, regular physical activity, and keeping optimal body weight," he added. Unabated, hypertension, also known as high ... Read more

Related support groups: Restless Legs Syndrome

Genes Linked to Restless Legs Syndrome Identified

Posted 14 Jul 2011 by Drugs.com

THURSDAY, July 14 – An international team of researchers has identified two genetic regions that seem to be implicated in restless legs syndrome. Restless legs syndrome is a condition in which people experience a tingling or "creepy crawly" feeling in the legs, relieved only by movement. One of the most common neurological diseases, the syndrome can lead to chronic sleep loss, daytime fatigue and even depression. In the new study, scientists from Europe, Canada and the United States analyzed genetic sequence variants in nearly 5,000 people suffering from restless legs syndrome along with more than 7,000 people who did not have the condition. The researchers found two new genetic regions that play a role in the syndrome. One of the regions is within a gene involved in regulating brain activity, known as TOX3, according to the report published online July 14 in PLoS Genetics. Although ... Read more

Related support groups: Restless Legs Syndrome

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tramadol, gabapentin, clonazepam, lamotrigine, clonidine, pregabalin, Mirapex, Requip, ropinirole, view more... Sinemet, pramipexole, levodopa, Neupro, carbidopa / levodopa, Horizant, gabapentin enacarbil, Sinemet CR, rotigotine, Parcopa, Repreve, Requip Starter Kit, Dopar, Larodopa, Atamet, ReQuip Follow on Pack, ReQuip Starter Pack