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Diabetes, Type 2 News (Page 3)

Related terms: Noninsulin-dependent Diabetes, Type 2 Diabetes, Diabetes, Type 2

FDA Medwatch Alert: Canagliflozin (Invokana, Invokamet) and Dapagliflozin (Farxiga, Xigduo XR): Drug Safety Communication - Strengthened Kidney Warnings

Posted 15 Jun 2016 by Drugs.com

ISSUE: FDA has strengthened the existing warning about the risk of acute kidney injury for the type 2 diabetes medicines canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR).  Based on recent reports, we have revised the warnings in the drug labels to include information about acute kidney injury and added recommendations to minimize this risk. BACKGROUND: Canagliflozin and dapagliflozin are prescription medicines used with diet and exercise to help lower blood sugar in adults with type 2 diabetes.  They belong to a class of drugs called sodium-glucose cotransporter-2 (SGLT2) inhibitors.  Canagliflozin and dapagliflozin lower blood sugar by causing the kidneys to remove sugar from the body through the urine. From March 2013, when canagliflozin was approved, to October 2015, FDA received reports of 101 confirmable cases* of acute kidney injury, some requiring ho ... Read more

Related support groups: Diabetes, Type 2, Invokana, Farxiga, Xigduo XR, Invokamet, Canagliflozin, Dapagliflozin, Canagliflozin/metformin, Dapagliflozin/metformin

Spare the Meat, Skip the Type 2 Diabetes?

Posted 14 Jun 2016 by Drugs.com

TUESDAY, June 14, 2016 – Eating a mainly plant-based diet – especially one with lots of healthy veggies, fruit and whole grains – may significantly lower your risk of type 2 diabetes, a new study suggests. "This study highlights that even moderate dietary changes in the direction of a healthful plant-based diet can play a significant role in the prevention of type 2 diabetes," said study lead author Ambika Satija, a postdoctoral fellow at the Harvard School of Public Health in Boston. "These findings provide further evidence to support current dietary recommendations for chronic disease prevention," Satija added in a school news release. The study included information from more than 200,000 Americans. They all completed a series of questionnaires about their diet, lifestyle, medical history and current health. The information was collected over 20 years. People who closely followed a ... Read more

Related support groups: Diabetes, Type 2, Dietary Supplementation, Dietary Fiber Supplementation

Brains of Teens With Type 2 Diabetes May Have Gray Matter Differences

Posted 14 Jun 2016 by Drugs.com

TUESDAY, June 14, 2016 – Teens with type 2 diabetes may have differences in gray matter in their brains, a small study found. Researchers conducted brain scans on 20 teens with type 2 diabetes and 20 teens without the blood sugar disease. Those with diabetes had less gray matter in six regions in their brains, and more gray matter in three regions. Some of these affected regions are involved in seeing and hearing, speech, memory, emotions, decision-making and self-control, the researchers said. Gray matter is where thinking occurs, experts noted. The Cincinnati Children's Hospital Medical Center team also found an association between less gray matter and the ability to pronounce and sound out unfamiliar words. "Previous studies suggested that youth with type 2 diabetes have changes in brain structure and poorer cognitive function scores compared to their peers," said senior study ... Read more

Related support groups: Diabetes, Type 2, Diagnosis and Investigation, Head Imaging

Type 2 Diabetes, Heart Disease a Dangerous Combo

Posted 13 Jun 2016 by Drugs.com

SATURDAY, June 11, 2016 – Prospects for people with type 2 diabetes and heart disease may be grimmer than previously believed, researchers report. "Type 2 diabetes accompanied by an acute coronary syndrome needs much more attention, especially in order to prevent yet another major cardiac event," said study leader Dr. William White. He is a professor with the University of Connecticut Health Center's Calhoun Cardiology Center. The study included more than 5,300 people around the world with type 2 diabetes. Those admitted to the hospital for congestive heart failure had a 24 percent to 28 percent chance of dying within 18 months. That's five times higher than the risk among those not hospitalized for a major heart problem, the researchers said. The risk of heart disease is two to three times higher among people with type 2 diabetes than in the general population, the study authors ... Read more

Related support groups: Diabetes, Type 2, Heart Disease, Heart Attack, Angina, Insulin Resistance, Pre-Diabetes, Myocardial Infarction, Coronary Artery Disease (CAD), Diabetes Mellitus, Acute Coronary Syndrome, Ischemic Heart Disease, Abnormal Glucose Tolerance, Acute Coronary Syndrome - Prophylaxis, Myocardial Infarction - Prophylaxis

Tight Blood Sugar Control Helps Fight Diabetic Eye Disease

Posted 13 Jun 2016 by Drugs.com

SATURDAY, June 11, 2016 – Intensive blood sugar control appears to reduce the risk of eye disease progression in people with type 2 diabetes, a new study says. People with type 2 diabetes are at risk for the eye disease called diabetic retinopathy. This condition damages tiny blood vessels in the retina, the light-sensitive tissue in the back of the eye. Researchers compared type 2 diabetes patients who received either intensive therapy or standard therapy to control blood sugar. To measure how well the therapy worked, people in the study had hemoglobin A1C tests. The A1C test estimates several months of blood sugar levels. People are diagnosed with diabetes when their A1C is 6.5 percent or higher, the U.S. National Institute of Diabetes and Digestive and Kidney Disease says. In general, the goal for people with type 2 diabetes is to have an A1C of less than 7 percent, according to the ... Read more

Related support groups: Diabetes, Type 2, Eye Conditions, Diabetes, Type 1, Insulin Resistance, Pre-Diabetes, Diabetes Mellitus, Diabetic Retinopathy, Abnormal Glucose Tolerance, Retinopathy Prophylaxis

Diabetes Doesn't Doom Seniors to Disability

Posted 13 Jun 2016 by Drugs.com

SATURDAY, June 11, 2016 – American seniors with diabetes are starting to live longer without disabilities, a new study finds. Researchers analyzed data from national surveys and found that adults with either type 1 or type 2 diabetes who were born in the 1940s generally became disabled at an older age than those born in the 1930s. Still, the study also found that after age 50, those with either type 1 or type 2 diabetes had a shorter life expectancy before age 70 and more years of living with disability than those without diabetes. "Over the past two decades, we have seen an increase in the length of good disability-free years of life in older Americans aged 50 to 70, both with and without diabetes," said study author Dr. Barbara Bardenheier, from the U.S. Centers for Disease Control and Prevention. "Our findings suggest that efforts to promote healthy lifestyles, advancements in the ... Read more

Related support groups: Diabetes, Type 2, Obesity, Weight Loss, Smoking, Smoking Cessation, Insulin Resistance, Pre-Diabetes, Diabetes Mellitus, Abnormal Glucose Tolerance

FDA Approves Once-Daily Jentadueto XR (linagliptin and metformin hydrochloride extended-release) for Type 2 Diabetes

Posted 11 Jun 2016 by Drugs.com

Ridgefield, Conn., and Indianapolis, May 31, 2016 – The U.S. Food and Drug Administration (FDA) has approved Jentadueto XR (linagliptin and metformin hydrochloride extended-release) tablets for the treatment of type 2 diabetes (T2D) in adults. Jentadueto XR, which is marketed by Boehringer Ingelheim and Eli Lilly and Company (NYSE: LLY), is the seventh new treatment from the Boehringer Ingelheim-Lilly Diabetes alliance to be approved by the FDA in the last five years. Jentadueto XR combines 2.5 mg or 5 mg of linagliptin with 1000 mg of metformin. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, works by increasing hormones that stimulate the pancreas to produce more insulin and the liver to produce less glucose. Metformin, a commonly prescribed initial treatment for T2D, lowers glucose production by the liver and its absorption in the intestine. “Adults with type 2 diabetes are ... Read more

Related support groups: Diabetes, Type 2, Metformin, Diabetes Mellitus, Jentadueto, Linagliptin, Linagliptin/metformin

3 Popular Diet Plans May Help Ease Type 2 Diabetes, Too

Posted 10 Jun 2016 by Drugs.com

FRIDAY, June 10, 2016 – People with type 2 diabetes may get some help with blood sugar control from a few commercial weight-loss programs, but conclusive evidence on most plans is lacking, a new review finds. Researchers reviewed 18 published studies. The studies looked at 10 popular, commercial weight-loss programs that involved a total of 764 people with type 2 diabetes. Three programs – Jenny Craig, Nutrisystem and Optifast – seemed to reduce blood sugar levels more than when people received weight-loss counseling alone, the review found. "A few of these programs may be a viable option for improving blood sugar control in patients with type 2 diabetes and those at risk for the disease, but we need more gold-standard studies to make that claim," said review leader Dr. Zoobia Chaudhry. Chaudhry is an assistant professor of medicine at Johns Hopkins University School of Medicine. The ... Read more

Related support groups: Diabetes, Type 2, Obesity, Weight Loss, Dietary Supplementation, Insulin Resistance, Pre-Diabetes, Diabetes Mellitus, Abnormal Glucose Tolerance

Intensive Blood Sugar Control May Be Too Much for Some With Type 2 Diabetes

Posted 6 Jun 2016 by Drugs.com

MONDAY, June 6, 2016 – Intensive treatment of blood sugar levels in some people with type 2 diabetes may cause serious complications, new research suggests. "In this study, we found that, particularly among older patients and patients with serious chronic conditions, intensive treatment nearly doubled the risk of severe hypoglycemia requiring medical attention, including hospitalization," said lead author Dr. Rozalina McCoy. She is an endocrinologist at the Mayo Clinic in Rochester, Minn. Hypoglycemia (low blood sugar) is a serious potential complication of diabetes treatment. The researchers said it can worsen quality of life and has been linked with cardiovascular events, dementia and death. The researchers reviewed information from more than 31,500 American adults. All had stable and controlled type 2 diabetes. None was taking insulin. None had a prior history of severe ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Dementia, Glucophage, Novolog, Glipizide, Humalog, Hypoglycemia, Janumet, Glyburide, Lantus Solostar, Invokana, Actos, Levemir, Glimepiride, Novolin R, Amaryl, Novolin N

Health Tip: Diabetes Can Harm Your Feet

Posted 2 Jun 2016 by Drugs.com

-- Foot problems are common among people with diabetes. Even a simple injury can turn into a big problem if you don't catch and treat it quickly. The American Diabetes Association mentions these typical foot problems: Developing nerve damage (neuropathy). Developing a change in the shape of your feet. Developing drying, peeling or cracking of the feet, which requires frequent moisturizing. Formation of calluses that may turn into open sores. Formation of sores that form from wearing shoes that don't fit properly. Having poor blood flow to the feet, which can lead to infection and slow healing. Read more

Related support groups: Diabetes, Type 2, Diabetes, Type 1, Diabetic Neuropathy, Diabetic Nerve Damage, Insulin Resistance, Pre-Diabetes, Diabetes Mellitus, Gestational Diabetes, Abnormal Glucose Tolerance, Foot Care

FDA Expands Indication of Invokamet (canagliflozin/metformin HCl) to Include First-Line Treatment of Type 2 Diabetes

Posted 31 May 2016 by Drugs.com

RARITAN, N.J., May 24, 2016 – Janssen Pharmaceuticals, Inc. (Janssen), today announced the U.S. Food and Drug Administration (FDA) has approved Invokamet, a fixed-dose combination therapy of INVOKANA® (canagliflozin) and metformin hydrochloride, for first-line treatment of adults with type 2 diabetes. With this new approval, Invokamet may now be prescribed in adults with type 2 diabetes who are not already being treated with canagliflozin or metformin and may benefit from dual therapy.[1] Invokamet, the first combination of a sodium glucose co–transporter 2 (SGLT2) inhibitor and metformin available in the United States, was previously approved by the FDA in August 2014 as an adjunct to diet and exercise to improve blood glucose control in adults with type 2 diabetes not adequately controlled by either canagliflozin or metformin, or who are already being treated with both medications sep ... Read more

Related support groups: Diabetes, Type 2, Metformin, Invokamet, Canagliflozin, Canagliflozin/metformin

Weight-Loss Surgery Helps Treat Type 2 Diabetes

Posted 24 May 2016 by Drugs.com

TUESDAY, May 24, 2016 – Weight-loss surgery quickly improves blood sugar control in people with type 2 diabetes, and should be recommended or considered as a treatment for certain obese people with diabetes. That's the message of a joint statement endorsed by 45 international professional organizations. It appears in the June issue of the journal Diabetes Care. "Given the rapid developments in the field, it is important to focus on this topic for those who care for individuals with diabetes. These new guidelines, based on the results of multiple clinical studies, validate that [weight-loss] surgery is indicated in certain people with diabetes and can yield significantly improved outcomes," editor-in-chief of Diabetes Care Dr. William Cefalu said in a journal news release. These are the first guidelines recommending surgery as a treatment option specifically for diabetes, he added. The ... Read more

Related support groups: Surgery, Diabetes, Type 2, Obesity, Weight Loss, Gastric Bypass Surgery, Gastrointestinal Surgery

No Welcome Mats for Diabetes, Obesity in 'Walkable' Neighborhoods

Posted 24 May 2016 by Drugs.com

TUESDAY, May 24, 2016 – If you live in a neighborhood where it's easy to walk to shops, schools and jobs, a new study says all that hoofing about appears to stave off excess weight and diabetes. The research found the rate of overweight and obesity increased in Ontario, Canada neighborhoods with poor "walkability" between 2001 and 2012. But overweight and obesity remained about the same in places where people can walk or bike where they need to go, the study reported. During that same period, the rate of diabetes remained about the same in less walkable areas, but declined in places that fostered walking and biking. "We know that the differences weren't because people in the most walkable neighborhoods were going to the gym more," said senior researcher Dr. Gillian Booth. "Their overall leisure time activities were not different, in terms of amount of energy expenditure. The difference ... Read more

Related support groups: Diabetes, Type 2, Obesity, Weight Loss, Insulin Resistance, Pre-Diabetes, Diabetes Mellitus, Abnormal Glucose Tolerance

At Least 1 Full-Time Nurse Per School, Pediatric Group Recommends

Posted 23 May 2016 by Drugs.com

MONDAY, May 23, 2016 – Every school should have at least one full-time registered nurse, a new American Academy of Pediatrics (AAP) policy statement says. "School nursing is one of the most effective ways to keep children healthy and in school and to prevent chronic absenteeism," Dr. Breena Welch Holmes, a lead author of the policy statement and chair of the AAP Council on School Health, said in an AAP news release. But school district policies about nurses may lack uniformity. And such policies often need updating, the AAP noted. In the past, the AAP supported having one school nurse for every 750 healthy students and one nurse for every 225 students who needed professional nursing assistance. But these ratios aren't enough to meet the health needs of today's students, the new policy says. "As student health needs became more complex, the school nursing role has expanded to include ... Read more

Related support groups: Diabetes, Type 2, Seizures, Allergic Reactions, Allergies, Attention-Deficit Hyperactivity Disorder (ADHD), Asthma, Asthma - Maintenance, Diabetes, Type 1, Oppositional Defiant Disorder, Seizure Prevention, Asthma - Acute, Anaphylaxis, Diabetes Mellitus, Seizure Prophylaxis, Allergic Asthma, Executive Function Disorder

FDA Medwatch Alert: Canagliflozin (Invokana, Invokamet): Drug Safety Communication - Clinical Trial Results Find Increased Risk of Leg and Foot Amputations

Posted 19 May 2016 by Drugs.com

ISSUE: FDA is alerting the public about interim safety results from an ongoing clinical trial that found an increase in leg and foot amputations, mostly affecting the toes, in patients treated with the diabetes medicine canagliflozin (Invokana, Invokamet). FDA has not determined whether canagliflozin increases the risk of leg and foot amputations. FDA is currently investigating this new safety issue and will update the public when we have more information. See the FDA Drug Safety Communication for additional details regarding the ongoing Canagliflozin Cardiovascular Assessment Study (CANVAS) clinical trial. BACKGROUND: Canagliflozin is a prescription medicine used with diet and exercise to lower blood sugar in adults with type 2 diabetes. It belongs to a class of drugs called sodium-glucose cotransporter-2 (SGLT2) inhibitors. Canagliflozin lowers blood sugar by causing the kidneys to ... Read more

Related support groups: Diabetes, Type 2, Invokana, Invokamet, Canagliflozin, Canagliflozin/metformin

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