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Anemia - Sickle Cell News

Related terms: Hemoglobin SS disease (Hb SS), Sickle Cell Anemia, Sickle Cell Disease, Hemoglobin SS disease, Hb SS

FDA Approves New Drug, Endari, for Sickle Cell Disease

Posted 17 days ago by Drugs.com

FRIDAY, July 7, 2017 – The U.S. Food and Drug Administration on Friday approved the first new drug for sickle cell disease in nearly two decades. Endari (L-glutamine oral powder) helps reduce severe complications associated with the blood disorder, the agency said. Sickle cell disease is an inherited disorder in which the red blood cells are shaped like a sickle, which limits the flow of vital oxygen to organs and tissues. In turn, this triggers severe pain and organ damage. Approximately 100,000 Americans, mostly minorities, have sickle cell disease, according to the U.S. National Institutes of Health. "Endari is the first treatment approved for patients with sickle cell disease in almost 20 years," said Dr. Richard Pazdur, acting director of the Office of Hematology and Oncology Products at the FDA's Center for Drug Evaluation and Research. "Until now, only one other drug was ... Read more

Related support groups: Blood Disorders, Bleeding Disorder, Anemia, Anemia - Sickle Cell, Coagulation Defects and Disorders

Sickle Cell Trait Tied to Higher Kidney Failure Risk for Blacks

Posted 9 Mar 2017 by Drugs.com

THURSDAY, March 9, 2017 – Black people with a trait for sickle cell anemia appear to have double the risk of kidney failure that requires dialysis, new research suggests. "Although you cannot change the genes you are born with, doctors can use this information to start screening for kidney disease earlier and to aggressively treat any other risk factors you may have such as diabetes or high blood pressure," said study co-leader Dr. Rakhi Naik. She's an assistant professor of medicine at Johns Hopkins University in Baltimore. Sickle cell anemia is an inherited disorder that affects hemoglobin – the substance in red blood cells that carries oxygen through the blood. This disease causes the hemoglobin to form in a sickle shape instead of the normal rounded disc shape, according to the U.S. National Heart, Lung, and Blood Institute. To have sickle cell anemia, a person must inherit the ... Read more

Related support groups: Renal Failure, Chronic Kidney Disease, Anemia - Sickle Cell, Diagnosis and Investigation

Gene Therapy: A Breakthrough for Sickle Cell Anemia?

Posted 2 Mar 2017 by Drugs.com

WEDNESDAY, March 1, 2017 – Researchers are reporting early success using gene therapy to treat, or even potentially cure, sickle cell anemia. The findings come from just one patient, a teenage boy in France. But more than 15 months after receiving the treatment, he remained free of symptoms and his usual medications. That's a big change from his situation before the gene therapy, according to his doctors at Necker Children's Hospital in Paris. For years, the boy had been suffering bouts of severe pain, as well as other sickle cell complications that affected his lungs, bones and spleen. Medical experts stressed, however, that much more research lies ahead before gene therapy can become an option for sickle cell anemia. It's not clear how long the benefits will last, they said. And the approach obviously has to be tested in more patients. "This is not right around the corner," said Dr. ... Read more

Related support groups: Fatigue, Dyspnea, Anemia - Sickle Cell

Sickle Cell Trait in Blacks Can Skew Diabetes Test Results

Posted 7 Feb 2017 by Drugs.com

TUESDAY, Feb. 7, 2017 – A blood test commonly used to diagnose and treat diabetes may be less accurate in black people who have the sickle cell anemia trait, a new study says. The test is called hemoglobin A1C (HbA1C). An A1C reading of 5.7 or more indicates prediabetes or diabetes; below 5.7 is normal, says the American Diabetes Association. But, the current study found that for blacks with a trait for sickle cell anemia, the A1C test may come back lower than it should. This discrepancy could lead to delays in diagnosis and treatment of diabetes, and it might also affect the management of known diabetes. When the researchers compared the results of A1C tests to other measures that check blood sugar levels, they showed that when A1C readings were expected to be 6 percent, they only registered 5.7 percent for blacks with sickle cell trait. "We want to make clinicians aware that things ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Glipizide, Glucophage, Novolog, Humalog, Insulin Resistance, Glyburide, Lantus Solostar, Levemir, Pre-Diabetes, Glimepiride, Novolin R, Amaryl, Novolin N, Diabetes Mellitus, Humulin N, Glucophage XR

New Drug Might Reduce Sickle Cell Pain Crises

Posted 4 Dec 2016 by Drugs.com

SATURDAY, Dec. 3, 2016 – An experimental drug may help reduce episodes of pain associated with sickle cell disease, a new study finds. Results of an early trial showed the drug – called SelG1 for now – reduced episodes of sickle cell-related pain crises by 45 percent. In addition, the drug appeared safe and was well-tolerated, researchers say. "Patients with sickle cell disease have complications, the most common of which is pain crises that require medical care and sometimes hospitalization," said lead researcher Dr. Kenneth Ataga. He's director of the sickle cell program at the University of North Carolina at Chapel Hill. People with inherited sickle cell disease have abnormally shaped red blood cells. These sickle-shaped cells stick to the walls of blood vessels, slowing and blocking normal blood flow. Blockage results in less blood and oxygen reaching cells, which in turn causes ... Read more

Related support groups: Hydroxyurea, Hydrea, Anemia - Sickle Cell, Diagnosis and Investigation, Droxia, Mylocel

Sickle Cell Trait Not Linked to Early Death in Study

Posted 3 Aug 2016 by Drugs.com

WEDNESDAY, Aug. 3, 2016 – New research challenges the long-held belief that people with sickle cell trait, who are born with only a single copy of the sickle cell gene variant, are at risk of premature death. People with the sickle cell gene variant do not have sickle cell disease, a blood disorder that shortens life span and causes sudden episodes of severe pain. People with the disease carry two copies of the gene, one from each parent. In the first-of-its-kind study, researchers followed nearly 48,000 black American soldiers on active duty in the U.S. Army over a four-year period. All had undergone tests for the genetic trait. "What we can say with confidence is that there's no evidence that it increases mortality in this Army population, and that's incredibly reassuring," said study co-author Lianne Kurina. She's an associate professor of medicine at Stanford University School of ... Read more

Related support groups: Blood Disorders, Anemia - Sickle Cell

Drug Protects Lung Function in Kids With Sickle Cell: Study

Posted 18 May 2016 by Drugs.com

WEDNESDAY, May 18, 2016 – Children with sickle cell disease may breathe easier when they're given hydroxyurea – an effective, but underused, drug for the disease, new research suggests. In a study of 94 young people with sickle cell, researchers found that hydroxyurea helped slow the decline in lung function that is typical of the disease. The study appears to be the first to show that hydroxyurea can preserve kids' lung function, said lead researcher Dr. Anya McLaren, of the Hospital for Sick Children in Toronto. She said the findings should give doctors more reason to prescribe hydroxyurea. The drug, she noted, is already known to prevent severe bouts of pain and serious lung complications in people with sickle cell. An expert who was not involved with the study agreed. "This is further confirmation that this medication is beneficial," said Dr. George Buchanan. He is a pediatric ... Read more

Related support groups: Anemia, Hydroxyurea, Anemia - Sickle Cell, Hydrea, Respiratory Distress Syndrome, Droxia, Mylocel

Sickle Cell Drug Doesn't Relieve Pain Crises: Study

Posted 8 Dec 2015 by Drugs.com

TUESDAY, Dec. 8, 2015 – The anti-clotting drug prasugrel does little to reduce the risk of pain crises in children with sickle cell disease, a new study shows. The research included 341 patients in 13 countries in Africa, the Americas, Asia, Europe and the Middle East. About half took prasugrel (Effient) for between nine and 24 months. The other half took a placebo. There was little difference between the two groups in rates of pain crises caused by interrupted blood flow in small blood vessels, the scientists found. Over time, repeated pain crises lead to tissue damage and chronic inflammation. The study was led by researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and University of California, San Francisco's Benioff Children's Hospital Oakland. "Although we were disappointed that prasugrel does not appear to ease the suffering of children with sickle cell ... Read more

Related support groups: Pain, Effient, Hydroxyurea, Hydrea, Anemia - Sickle Cell, Prasugrel, Droxia, Mylocel

Health Tip: Recognizing Signs of Anemia

Posted 18 Jun 2015 by Drugs.com

-- Anemia occurs when there are insufficient red blood cells, or they don't function properly. The American Society of Hematology says warning signs include: Feeling weak or dizzy. Having colder hands and feet. Having pale skin or a yellow tint. Feeling short of breath. Having an irregular or fast heartbeat. Hearing a whooshing sound or pounding in the ears. Having frequent chest pain or headache. Read more

Related support groups: Anemia, Iron Deficiency Anemia, Folic Acid Deficiency, Anemia - Sickle Cell, Aplastic Anemia, Pernicious Anemia, B12 Nutritional Deficiency, Autoimmune Hemolytic Anemia, Anemia Associated with Iron Deficiency, Hemolytic Anemia, Anemia, Megaloblastic, Anemia Associated with Chronic Disease, Anemia - Posthemorrhagic, Erythroblastopenia, Schilling Test, Anemia Associated with Vitamin B12 Deficiency, G-6-PD Deficiency, Anemia Associated with Prematurity, Folic Acid/Cyanocobalamin Deficiency, Anemia of Unspecified Nutritional Deficiency

Woman Gives Birth Using Ovary Tissue Frozen in Childhood

Posted 10 Jun 2015 by Drugs.com

WEDNESDAY, June 10, 2015 – In what researchers are hailing as a medical breakthrough, a 27-year-old woman gave birth to a healthy baby conceived from ovarian tissue that had been surgically removed and frozen when she was a child. Although this procedure has been used in adults, it wasn't clear if freezing immature ovarian tissue would be able to successfully restore fertility later. The researchers said this procedure could be an important advancement for preserving fertility for young women or girls who need disease treatments that might destroy their ovarian function, such as cancer. "This is a message of hope for all the children with high risk of premature ovarian failure to improve their future quality of life," said lead researcher Dr. Isabelle Demeestere, a gynecologist and research associate in the Fertility Clinic and Research Laboratory on Human Reproduction at Erasme ... Read more

Related support groups: Female Infertility, Anemia - Sickle Cell, Primary Ovarian Failure, Follicle Stimulation

Few Sickle Cell Patients Receiving Beneficial Drug, Study Finds

Posted 28 Apr 2015 by Drugs.com

TUESDAY, April 28, 2015 – Few U.S. adults with sickle cell anemia are getting a recommended medication that can help them manage pain, breathing problems and other debilitating symptoms, according to a new study. Using a national database, researchers found that less than one-quarter of sickle cell patients who should have been taking a drug called hydroxyurea actually were. "This is a medication that's highly beneficial and yet most people aren't getting it," said Dr. George Buchanan, a sickle cell expert, and a professor at the University of Texas Southwestern Medical Center at Dallas, who was not involved in the new study. Findings from the study were reported in the April 28 issue of the Journal of the American Medical Association. Sickle cell anemia is an inherited disease that mainly affects people of African, South American or Mediterranean descent. In the United States, about ... Read more

Related support groups: Hydroxyurea, Hydrea, Anemia - Sickle Cell, Droxia, Mylocel

Sickle Cell Anemia Treatment So Successful in Kids That Trial Is Halted

Posted 21 Nov 2014 by Drugs.com

FRIDAY, Nov. 21, 2014 – A clinical trial of hydroxyurea therapy for children with sickle cell anemia has been halted a year early because the results show it is a safe and effective way to manage the disease and reduce the risk of stroke. The announcement about the research, which was conducted at 25 medical centers in the United States and Canada, was made this week by the U.S. National Heart, Lung, and Blood Institute (NHLBI). Researchers compared monthly blood transfusions with daily hydroxyurea pills among children with sickle cell anemia who were at high risk of stroke. To determine this, they measured the velocity of blood flow to the brain in these young patients. With sickle cell anemia, red blood cells become stiff and sickle-shaped, blocking blood flow throughout the body. Hydroxyurea was first developed as a cancer drug, but with sickle cell anemia it reduces the number of ... Read more

Related support groups: Hydroxyurea, Hydrea, Anemia - Sickle Cell, Droxia, Mylocel

Scientists Studying Sickle Cell Trait

Posted 18 Sep 2014 by Drugs.com

THURSDAY, Sept. 18, 2014 – Researchers are trying to learn more about a condition called sickle cell trait, which can cause sudden death in young athletes. In people with sickle cell trait, intense physical activity, heat and dehydration can cause muscle breakdown that can lead to kidney damage and cardiac arrest. Between 2000 and 2014, nine collegiate football players in the United States collapsed and died during training and were later found to have sickle cell trait. "More student-athletes with sickle cell trait have died than those with any other condition, including heart defects," Dr. John Wood, of the Saban Research Institute at Children's Hospital Los Angeles, said in a hospital news release. "Sickle cell trait should not be a barrier to an active lifestyle or competitive sports, but the problem is that many people won't have any warning symptoms. Because of that, they don't ... Read more

Related support groups: Anemia - Sickle Cell

New Guidelines for Sickle Cell Disease

Posted 10 Sep 2014 by Drugs.com

WEDNESDAY, Sept. 10, 2014 – An expert panel has issued new guidelines for managing sickle cell disease, stressing the use of the drug hydroxyurea and transfusions for many with the genetic disorder. "This is a major step forward to try to put together all of the evidence and try to highlight what is most important," said Dr. Barbara Yawn, professor of family and community health at Olmsted Medical Center in Rochester, Minn. Yawn was also co-chair of the panel convened by the U.S. National Heart, Lung, and Blood Institute to develop the new guidelines. As many as 100,000 Americans have sickle cell disease, according to background information with the guidelines. In sickle cell disease, the body makes sickle-shaped or crescent-shaped red blood cells. Normal red blood cells are disc-shaped, like a doughnut without holes, allowing the cells to move easily through blood vessels. Sickle ... Read more

Related support groups: Hydroxyurea, Hydrea, Anemia - Sickle Cell, Droxia, Mylocel

Less Toxic Transplant Treatment Offers Hope for Sickle Cell Patients

Posted 1 Jul 2014 by Drugs.com

TUESDAY, July 1, 2014 – A new bone marrow transplant technique for adults with sickle cell disease may "cure" many patients. And it avoids the toxic effects associated with long-term use of anti-rejection drugs, a new study suggests. This experimental technique mixes stem cells from a sibling with the patient's own cells. Of 30 patients treated this way, many stopped using anti-rejection drugs within a year, and avoided serious side effects of transplants – rejection and graft-versus-host disease, in which donor cells attack the recipient cells, the researchers said. "We can successfully reverse sickle cell disease with a partial bone marrow transplant in very sick adult patients without the need for long-term medications," said researcher Dr. John Tisdale, a senior investigator at the U.S. National Heart, Lung, and Blood Institute. In the United States, more than 90,000 people have ... Read more

Related support groups: Anemia - Sickle Cell

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