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Related terms: Hemoglobin SS disease (Hb SS), Sickle Cell Anemia, Sickle Cell Disease, Hemoglobin SS disease, Hb SS

New Drug Might Reduce Sickle Cell Pain Crises

Posted 5 days ago by Drugs.com

SATURDAY, Dec. 3, 2016 – An experimental drug may help reduce episodes of pain associated with sickle cell disease, a new study finds. Results of an early trial showed the drug – called SelG1 for now – reduced episodes of sickle cell-related pain crises by 45 percent. In addition, the drug appeared safe and was well-tolerated, researchers say. "Patients with sickle cell disease have complications, the most common of which is pain crises that require medical care and sometimes hospitalization," said lead researcher Dr. Kenneth Ataga. He's director of the sickle cell program at the University of North Carolina at Chapel Hill. People with inherited sickle cell disease have abnormally shaped red blood cells. These sickle-shaped cells stick to the walls of blood vessels, slowing and blocking normal blood flow. Blockage results in less blood and oxygen reaching cells, which in turn causes ... Read more

Related support groups: Hydroxyurea, Hydrea, Anemia - Sickle Cell, Diagnosis and Investigation, Droxia, Mylocel

Sickle Cell Trait Not Linked to Early Death in Study

Posted 3 Aug 2016 by Drugs.com

WEDNESDAY, Aug. 3, 2016 – New research challenges the long-held belief that people with sickle cell trait, who are born with only a single copy of the sickle cell gene variant, are at risk of premature death. People with the sickle cell gene variant do not have sickle cell disease, a blood disorder that shortens life span and causes sudden episodes of severe pain. People with the disease carry two copies of the gene, one from each parent. In the first-of-its-kind study, researchers followed nearly 48,000 black American soldiers on active duty in the U.S. Army over a four-year period. All had undergone tests for the genetic trait. "What we can say with confidence is that there's no evidence that it increases mortality in this Army population, and that's incredibly reassuring," said study co-author Lianne Kurina. She's an associate professor of medicine at Stanford University School of ... Read more

Related support groups: Blood Disorders, Anemia - Sickle Cell

Drug Protects Lung Function in Kids With Sickle Cell: Study

Posted 18 May 2016 by Drugs.com

WEDNESDAY, May 18, 2016 – Children with sickle cell disease may breathe easier when they're given hydroxyurea – an effective, but underused, drug for the disease, new research suggests. In a study of 94 young people with sickle cell, researchers found that hydroxyurea helped slow the decline in lung function that is typical of the disease. The study appears to be the first to show that hydroxyurea can preserve kids' lung function, said lead researcher Dr. Anya McLaren, of the Hospital for Sick Children in Toronto. She said the findings should give doctors more reason to prescribe hydroxyurea. The drug, she noted, is already known to prevent severe bouts of pain and serious lung complications in people with sickle cell. An expert who was not involved with the study agreed. "This is further confirmation that this medication is beneficial," said Dr. George Buchanan. He is a pediatric ... Read more

Related support groups: Anemia, Hydroxyurea, Anemia - Sickle Cell, Hydrea, Respiratory Distress Syndrome, Droxia, Mylocel

Sickle Cell Drug Doesn't Relieve Pain Crises: Study

Posted 8 Dec 2015 by Drugs.com

TUESDAY, Dec. 8, 2015 – The anti-clotting drug prasugrel does little to reduce the risk of pain crises in children with sickle cell disease, a new study shows. The research included 341 patients in 13 countries in Africa, the Americas, Asia, Europe and the Middle East. About half took prasugrel (Effient) for between nine and 24 months. The other half took a placebo. There was little difference between the two groups in rates of pain crises caused by interrupted blood flow in small blood vessels, the scientists found. Over time, repeated pain crises lead to tissue damage and chronic inflammation. The study was led by researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and University of California, San Francisco's Benioff Children's Hospital Oakland. "Although we were disappointed that prasugrel does not appear to ease the suffering of children with sickle cell ... Read more

Related support groups: Pain, Effient, Hydroxyurea, Hydrea, Anemia - Sickle Cell, Prasugrel, Droxia, Mylocel

Health Tip: Recognizing Signs of Anemia

Posted 18 Jun 2015 by Drugs.com

-- Anemia occurs when there are insufficient red blood cells, or they don't function properly. The American Society of Hematology says warning signs include: Feeling weak or dizzy. Having colder hands and feet. Having pale skin or a yellow tint. Feeling short of breath. Having an irregular or fast heartbeat. Hearing a whooshing sound or pounding in the ears. Having frequent chest pain or headache. Read more

Related support groups: Anemia, Iron Deficiency Anemia, Anemia - Sickle Cell, Folic Acid Deficiency, Aplastic Anemia, Pernicious Anemia, B12 Nutritional Deficiency, Anemia Associated with Iron Deficiency, Autoimmune Hemolytic Anemia, Hemolytic Anemia, Anemia, Megaloblastic, Anemia Associated with Vitamin B12 Deficiency, Anemia Associated with Chronic Disease, Anemia - Posthemorrhagic, Erythroblastopenia, Schilling Test, Anemia Associated with Prematurity, G-6-PD Deficiency, Folic Acid/Cyanocobalamin Deficiency, Anemia of Unspecified Nutritional Deficiency

Woman Gives Birth Using Ovary Tissue Frozen in Childhood

Posted 10 Jun 2015 by Drugs.com

WEDNESDAY, June 10, 2015 – In what researchers are hailing as a medical breakthrough, a 27-year-old woman gave birth to a healthy baby conceived from ovarian tissue that had been surgically removed and frozen when she was a child. Although this procedure has been used in adults, it wasn't clear if freezing immature ovarian tissue would be able to successfully restore fertility later. The researchers said this procedure could be an important advancement for preserving fertility for young women or girls who need disease treatments that might destroy their ovarian function, such as cancer. "This is a message of hope for all the children with high risk of premature ovarian failure to improve their future quality of life," said lead researcher Dr. Isabelle Demeestere, a gynecologist and research associate in the Fertility Clinic and Research Laboratory on Human Reproduction at Erasme ... Read more

Related support groups: Female Infertility, Anemia - Sickle Cell, Primary Ovarian Failure, Follicle Stimulation

Few Sickle Cell Patients Receiving Beneficial Drug, Study Finds

Posted 28 Apr 2015 by Drugs.com

TUESDAY, April 28, 2015 – Few U.S. adults with sickle cell anemia are getting a recommended medication that can help them manage pain, breathing problems and other debilitating symptoms, according to a new study. Using a national database, researchers found that less than one-quarter of sickle cell patients who should have been taking a drug called hydroxyurea actually were. "This is a medication that's highly beneficial and yet most people aren't getting it," said Dr. George Buchanan, a sickle cell expert, and a professor at the University of Texas Southwestern Medical Center at Dallas, who was not involved in the new study. Findings from the study were reported in the April 28 issue of the Journal of the American Medical Association. Sickle cell anemia is an inherited disease that mainly affects people of African, South American or Mediterranean descent. In the United States, about ... Read more

Related support groups: Hydroxyurea, Hydrea, Anemia - Sickle Cell, Droxia, Mylocel

Sickle Cell Anemia Treatment So Successful in Kids That Trial Is Halted

Posted 21 Nov 2014 by Drugs.com

FRIDAY, Nov. 21, 2014 – A clinical trial of hydroxyurea therapy for children with sickle cell anemia has been halted a year early because the results show it is a safe and effective way to manage the disease and reduce the risk of stroke. The announcement about the research, which was conducted at 25 medical centers in the United States and Canada, was made this week by the U.S. National Heart, Lung, and Blood Institute (NHLBI). Researchers compared monthly blood transfusions with daily hydroxyurea pills among children with sickle cell anemia who were at high risk of stroke. To determine this, they measured the velocity of blood flow to the brain in these young patients. With sickle cell anemia, red blood cells become stiff and sickle-shaped, blocking blood flow throughout the body. Hydroxyurea was first developed as a cancer drug, but with sickle cell anemia it reduces the number of ... Read more

Related support groups: Hydroxyurea, Hydrea, Anemia - Sickle Cell, Droxia, Mylocel

Scientists Studying Sickle Cell Trait

Posted 18 Sep 2014 by Drugs.com

THURSDAY, Sept. 18, 2014 – Researchers are trying to learn more about a condition called sickle cell trait, which can cause sudden death in young athletes. In people with sickle cell trait, intense physical activity, heat and dehydration can cause muscle breakdown that can lead to kidney damage and cardiac arrest. Between 2000 and 2014, nine collegiate football players in the United States collapsed and died during training and were later found to have sickle cell trait. "More student-athletes with sickle cell trait have died than those with any other condition, including heart defects," Dr. John Wood, of the Saban Research Institute at Children's Hospital Los Angeles, said in a hospital news release. "Sickle cell trait should not be a barrier to an active lifestyle or competitive sports, but the problem is that many people won't have any warning symptoms. Because of that, they don't ... Read more

Related support groups: Anemia - Sickle Cell

New Guidelines for Sickle Cell Disease

Posted 10 Sep 2014 by Drugs.com

WEDNESDAY, Sept. 10, 2014 – An expert panel has issued new guidelines for managing sickle cell disease, stressing the use of the drug hydroxyurea and transfusions for many with the genetic disorder. "This is a major step forward to try to put together all of the evidence and try to highlight what is most important," said Dr. Barbara Yawn, professor of family and community health at Olmsted Medical Center in Rochester, Minn. Yawn was also co-chair of the panel convened by the U.S. National Heart, Lung, and Blood Institute to develop the new guidelines. As many as 100,000 Americans have sickle cell disease, according to background information with the guidelines. In sickle cell disease, the body makes sickle-shaped or crescent-shaped red blood cells. Normal red blood cells are disc-shaped, like a doughnut without holes, allowing the cells to move easily through blood vessels. Sickle ... Read more

Related support groups: Hydroxyurea, Hydrea, Anemia - Sickle Cell, Droxia, Mylocel

Less Toxic Transplant Treatment Offers Hope for Sickle Cell Patients

Posted 1 Jul 2014 by Drugs.com

TUESDAY, July 1, 2014 – A new bone marrow transplant technique for adults with sickle cell disease may "cure" many patients. And it avoids the toxic effects associated with long-term use of anti-rejection drugs, a new study suggests. This experimental technique mixes stem cells from a sibling with the patient's own cells. Of 30 patients treated this way, many stopped using anti-rejection drugs within a year, and avoided serious side effects of transplants – rejection and graft-versus-host disease, in which donor cells attack the recipient cells, the researchers said. "We can successfully reverse sickle cell disease with a partial bone marrow transplant in very sick adult patients without the need for long-term medications," said researcher Dr. John Tisdale, a senior investigator at the U.S. National Heart, Lung, and Blood Institute. In the United States, more than 90,000 people have ... Read more

Related support groups: Anemia - Sickle Cell

Sickle Cell Drug Reduces Symptoms, Health Costs Alike, Study Finds

Posted 17 Sep 2013 by Drugs.com

MONDAY, Sept. 16 – A drug used to treat sickle cell disease can not only reduce complications, but also cut health-care costs associated with treating children affected by this painful condition, according to a new study. Sickle cell disease is a genetic disorder affecting people of African, Middle Eastern, Mediterranean and Hispanic descent. The new cost-benefit analysis found that young children whose treatment included a daily dose of hydroxyurea had fewer hospitalizations, blood transfusions and less pain. They also had medical costs that were on average $3,000 less than children who received standard therapy. "In addition to alleviating the human suffering in sickle cell disease, we found that hydroxyurea had the pleasant 'side effect' of substantially lowering the cost of care among children treated with it," study investigator Dr. James Casella, director of pediatric hematology ... Read more

Related support groups: Hydroxyurea, Hydrea, Anemia - Sickle Cell, Droxia, Mylocel

Sickle Cell Anemia on Rise in Newborns Worldwide

Posted 18 Jul 2013 by Drugs.com

TUESDAY, July 16 – Sickle cell anemia is increasing worldwide, and more than 400,000 babies will be born with the hereditary blood disorder in 2050, according to a new study. In sickle cell anemia, red blood cells shaped like sickles, or crescent moons, can get stuck in small blood vessels around the body, blocking the flow of blood and oxygen. The number of newborns with the disease is likely to increase from about 305,800 in 2010 to about 404,200 in 2050, researchers determined, using estimated country rates of sickle cell anemia and information on projected birth rates. Newborns in India, Nigeria and the Democratic Republic of the Congo accounted for 57 percent of all babies worldwide born with sickle cell anemia in 2010 and this proportion will likely increase by 2050. Universal screening programs could save the lives of nearly 10 million newborns with sickle cell anemia worldwide, ... Read more

Related support groups: Anemia - Sickle Cell

Blood Transfusions May Mean Fewer Strokes in Kids With Sickle Cell Disease

Posted 24 Jun 2013 by Drugs.com

MONDAY, June 24 – A new study suggests that an increase in blood transfusions for patients with sickle cell disease may have caused a drop in the number of black children suffering from ischemic strokes – attacks brought about by a blockage in an artery. Black children, however, still have a much greater risk of death from hemorrhagic (bleeding) strokes than white children, the new study finds. Sickle cell disease gets its name from the shape of the red blood cells in someone who has it. They're crescent-shaped, similar to a farm tool called a sickle. These abnormally shaped red blood cells become hard and sticky and can clog the blood vessels, creating pain, according to the U.S. Centers for Disease Control and Prevention. In the new study, researchers led by Dr. Laura Lehman of Boston Children's Hospital analyzed U.S. death certificate data for all children who died from 1988 ... Read more

Related support groups: Anemia - Sickle Cell

Debate Heats Up Over Screening Athletes for Sickle Cell Trait

Posted 28 Dec 2012 by Drugs.com

FRIDAY, Dec. 28 – Though heart problems or heatstroke generally are to blame for a young athlete's sudden death, experts now know that carrying an aberration called the sickle cell trait also poses substantial risk. That has led to mandatory screening for anyone hoping to participate in National Collegiate Athletic Association Division I athletics. Not everyone, however, thinks that's a good idea. Having the sickle cell trait is different from having sickle cell disease. People with the sickle cell trait inherited a sickle cell gene from one parent, but not both. Because they just inherited one gene, they won't have sickle cell disease, which develops because of abnormal red blood cells that can lead to anemia, pain, infection, and organ damage. In the United States, an estimated one of every 500 blacks and one of every 36,000 Hispanics have sickle cell disease. By contrast, one of ... Read more

Related support groups: Anemia - Sickle Cell

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