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What is the difference between Symdeko and Kalydeco?

Answers (1)

Official Answer by Drugs.com 7 Mar 2018

There are several differences between Symdeko (tezacaftor/ivacaftor and ivacaftor) and Kalydeco (ivacaftor), including what groups they treat. Symdeko is used in cystic fibrosis patients 12 years and older who have two copies of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or who have at least one mutation that is responsive to tezacaftor/ivacaftor. Kalydeco, which contains the single ingredient ivacaftor, is also used to treat cystic fibrosis, but in patients age 2 years and older who have only one mutation in the CFTR gene that is responsive to ivacaftor. Both Symdeko and Kalydeco are manufactured by Vertex Pharmaceuticals.

What is the dose of Symdeko?

The recommended dose for Symdeko is one yellow tablet (tezacaftor 100 mg/ivacaftor 150 mg) taken in the morning and one light blue tablet (ivacaftor 150 mg) taken in the evening, approximately 12 hours apart with a fat-containing food. Examples of meals or snacks that contain fat are those prepared with butter or oils or those containing eggs, cheeses, nuts, whole milk, or meats.

What is the dose of Kalydeco?

Kalydeco is available as tablets for patients 6 years or older and as granules for use in children ages 2 to less than 6 years. The recommended dose of Kalydeco for both adults and children ages 6 years and older is one 150 mg tablet taken by mouth every 12 hours (300 mg total daily dose) with a fat-containing food. The granules are dosed based on the weight of the child. In children 2 to less than 6 years of age that weigh less than 14 kg, the dose is one 50 mg packet every 12 hours (100 mg total daily dose). In children 2 to less than 6 years of age that weigh 14 kg or greater, the dose is one 75 mg packet every 12 hours (150 mg total daily dose). Meals or snacks that contain fat include those made with butter or oils or containing eggs, cheeses, nuts, whole milk, or meats.

How does Kalydeco work?

Kalydeco (ivacaftor) works in cystic fibrosis by helping the "gates" of the CFTR proteins stay open. This allows more chloride ions to move in and out of cells to help balance levels of salt and water in the lungs.

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