Votrient

Pronunciation

Generic Name: pazopanib (paz OH pa nib)
Brand Names: Votrient

What is Votrient?

Votrient (pazopanib) is a cancer medication that interferes with the growth of cancer cells and slows their spread in the body.

Votrient is used to treat advanced renal cell carcinoma (kidney cancer).

Votrient is also used to treat soft tissue sarcoma (a tumor that can develop in or around muscles, tendons, joints, organs, or blood vessels). Pazopanib is usually given after other cancer medications have been tried without successful treatment of soft tissue sarcoma.

Important information

You should not use Votrient if you are allergic to pazopanib, or if you have severe liver disease.

Votrient can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

Slideshow: View Frightful (But Dead Serious) Drug Side Effects

Before taking this medicine

You should not use Votrient if you are allergic to pazopanib, or if you have severe liver disease.

To make sure you can safely take Votrient, tell your doctor if you have any of these other conditions:

  • liver disease;

  • heart disease, heart rhythm disorder;

  • high blood pressure;

  • a personal or family history of Long QT syndrome;

  • a history of blood clot or stroke;

  • a thyroid disorder;

  • an ulcer or other stomach disorder;

  • headaches, seizures, or vision problems;

  • a head injury or bleeding in your brain within the past 6 months;

  • stomach or intestinal bleeding within the past 6 months; or

  • if you have had surgery within the past 7 days.

FDA pregnancy category D. Do not use Votrient if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

See also: Pregnancy and breastfeeding warnings (in more detail)

It is not known whether pazopanib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using Votrient.

How should I take Votrient?

Take Votrient exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take Votrient on an empty stomach, at least 1 hour before or 2 hours after a meal.

Do not crush a Votrient tablet. Swallow the pill whole. Crushing the pill may cause your body to absorb too much of the drug at one time.

While using Votrient, you may need frequent blood or urine tests. Your blood pressure will also need to be checked often. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).

If you need surgery, tell the surgeon ahead of time that you are using Votrient. You may need to stop using the medicine for at least 7 days before your surgery.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 12 hours away. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Pazopanib can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Patients and caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.

Grapefruit and grapefruit juice may interact with Votrient and lead to potentially dangerous effects. Avoid the use of grapefruit products while taking this medicine.

Votrient side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Votrient: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Votrient and call your doctor at once if you have:

  • slow healing of a wound or surgical incision;

  • dizziness, fainting, fast or pounding heartbeat;

  • fever, chills, easy bruising, flu symptoms, sores in your mouth and throat;

  • feeling short of breath (even with mild exertion), swelling, rapid weight gain;

  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • nosebleed, bleeding gums;

  • any wound that will not heal;

  • nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • sudden numbness or weakness (especially on one side of the body), sudden severe headache, confusion, problems with vision, speech, or balance;

  • seizures (convulsions);

  • sudden cough, wheezing, rapid breathing, coughing up blood;

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

  • pain, swelling, warmth, or redness in one or both legs; or

  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Common Votrient side effects may include:

  • mild nausea or vomiting, diarrhea;

  • weight loss;

  • changes in hair or skin color;

  • joint or muscle pain;

  • tumor pain, mild headache; or

  • unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Votrient?

Many drugs can interact with Votrient. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Votrient, especially:

  • ADHD medications;

  • an antibiotic or antifungal medication;

  • an antidepressant or medicine to treat a psychiatric disorder;

  • asthma or allergy medication;

  • cholesterol-lowering drugs, especially simvastatin (Zocor, Simcor, Vytorin, Juvisync);

  • diabetes medication you take by mouth;

  • drugs to treat erectile dysfunction;

  • heart or blood pressure medications, heart rhythm medication;

  • HIV or AIDS medications;

  • medicines used to prevent organ transplant rejection;

  • medicine to treat or prevent nausea and vomiting;

  • migraine headache medicines, including ergot medicines or "triptans";

  • sedatives or narcotic pain medication;

  • seizure medication; or

  • a steroid.

This list is not complete and many other drugs can interact with Votrient. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

  • Your pharmacist can provide more information about Votrient.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 5.02. Revision Date: 2013-07-09, 11:00:05 AM.

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