Generic Name: omeprazole and sodium bicarbonate (oh ME pray zol and SO dee um by KAR bon ate)
Brand Names: Zegerid, Zegerid OTC

What is Zegerid?

Zegerid contains a combination of omeprazole and sodium bicarbonate. Omeprazole is a proton pump inhibitor that decreases the amount of acid your stomach produces. Sodium bicarbonate is an antacid that raises the pH in your stomach to keep the omeprazole from breaking down in stomach acid.

Zegerid is used to treat heartburn and other symptoms of gastroesophageal reflux disease (GERD). This medicine is also used to treat ulcers and other conditions involving excessive stomach acid production.

Zegerid is not for immediate relief of heartburn symptoms.

Zegerid may also be used for purposes not listed in this medication guide.

Important information

Zegerid is a combination medicine used to treat heartburn and other symptoms of gastroesophageal reflux disease (GERD). This medicine is also used to treat ulcers and other conditions involving excessive stomach acid production. Symptom relief does not mean that serious stomach problems (like cancer) do not exist. Talk to your doctor if old stomach symptoms return or new symptoms appear.

Slideshow: 2014 Update - First Time Brand-to-Generic Switches

Zegerid contains sodium bicarbonate, a form of salt. If you are on a low-salt or low-sodium diet, you may not be able to use Zegerid. Talk with your doctor.

This medication can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Zegerid and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Before taking this medicine

You should not take Zegerid if you are allergic to omeprazole or sodium bicarbonate.

Zegerid contains sodium bicarbonate, a form of salt. Each capsule contains the equivalent of 300 mg of sodium. Each packet of powder contains the equivalent of 460 mg of sodium. If you are on a low-salt or low-sodium diet, you may not be able to use Zegerid. Talk with your doctor.

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

To make sure this medicine is safe for you, tell your doctor if you have:

  • kidney or liver disease;

  • heart disease;

  • metabolic or respiratory alkalosis (usually after prolonged illness); or

  • low levels of calcium, magnesium, or potassium levels in your blood.

Some people taking omeprazole may have an increased risk of bone fracture in the hip, wrist, or spine. This effect has occurred mostly in people taking omeprazole long term or at high doses, and in people who are age 50 and older. Omeprazole may not be the actual cause of increased fracture risk. Before you take this medication, tell your doctor if you have a bone disorder.

Some conditions are treated with a combination of antibiotics with Zegerid. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

FDA pregnancy category C. It is not known whether Zegerid will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

See also: Pregnancy and breastfeeding warnings (in more detail)

Omeprazole and sodium bicarbonate can pass into breast milk and may harm a nursing baby. You should not breast-feed while using Zegerid.

How should I take Zegerid?

Take Zegerid exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine on an empty stomach, at least 1 hour before eating a meal. If this medicine is given to a person who is fed through a nasogastric (NG) tube, the feeding should be stopped at least 3 hours before giving the medicine. Do not restart nasogastric feeding for at least 1 hour after giving Zegerid.

Take the Zegerid capsule with a full glass of water. Do not use any other type of liquid or food.

Do not open the capsule or empty the medicine powder from it. Swallow the capsule whole.

To use the powder form, open a packet and pour all of the powder into a small cup with 1 or 2 tablespoons of water. Do not use any other type of liquid. Stir the mixture and drink it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

The 20-mg and the 40-mg forms of this medicine contain the same strength of sodium bicarbonate. Do not use two 20-mg capsules to equal one 40-mg capsule. Do not use two 20-mg powder packets to equal one 40-mg powder packet. If you do not use the exact capsule or powder packet your doctor has prescribed, you may receive too much sodium bicarbonate.

Store Zegerid at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

This medication can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Zegerid and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Avoid taking this medicine with milk if you use Zegerid long-term.

Zegerid side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Zegerid: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • stiffness or loss of movement in any part of your body;

  • diarrhea that is watery or bloody;

  • fast or slow heartbeats;

  • seizure (convulsions); or

  • low magnesium (dizziness, confusion, fast or uneven heart rate, jerking muscle movements, jittery feeling, muscle cramps, muscle weakness or limp feeling, cough or choking feeling).

Common Zegerid side effects may include:

  • headache;

  • nausea, stomach pain, gas; or

  • mild diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Zegerid?

Zegerid can change the way your body absorbs or eliminates certain other drugs. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Zegerid, especially:

  • bosentan;

  • citalopram;

  • clopidogrel;

  • cyclosporine;

  • diazepam (Valium) or similar sedatives;

  • digoxin, digitalis;

  • disulfiram, Antabuse;

  • methotrexate;

  • rifabutin, rifampin, rifapentine;

  • sodium polystyrene sulfonate;

  • St. John's wort;

  • tacrolimus;

  • an antibiotic--ampicillin, clarithromycin, nafcillin, rifampin;

  • an antifungal medicine--ketoconazole, voriconazole;

  • a blood thinner such as warfarin, Coumadin;

  • calcium supplements or iron supplements (including ferrous fumarate, ferrous gluconate, ferrous sulfonate);

  • a diuretic or "water pill";

  • HIV medicine--atazanavir, efavirenz, nelfinavir, nevirapine, rilpivirine, ritonavir, saquinavir; or

  • seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone.

This list is not complete and other drugs may interact with Zegerid. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Zegerid.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Zegerid only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Copyright 1996-2014 Cerner Multum, Inc. Version: 11.03. Revision Date: 2013-02-14, 12:03:26 PM.

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