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Pro-Pen-G Injection

This page contains information on Pro-Pen-G Injection for veterinary use.
The information provided typically includes the following:
  • Pro-Pen-G Injection Indications
  • Warnings and cautions for Pro-Pen-G Injection
  • Direction and dosage information for Pro-Pen-G Injection

Pro-Pen-G Injection

This treatment applies to the following species:
Manufacturer: Bimeda


Aqueous Suspension


300,000 Units per mL


For Intramuscular Use Only


Penicillin G Procaine Injectable Suspension Alternative Method is available in 100-mL, 250-mL and 500-mL multiple-dose vials. Each mL contains: penicillin G procaine 300,000 units*, procaine hydrochloride 130.8 mg*, methylparaben 1.3 mg, propylparaben 0.2 mg, sodium citrate 10 mg, sodium carboxymethylcellulose 1 mg, povidone 5 mg, lecithin 6 mg, sodium formaldehyde sulfoxylate 0.2 mg, procaine hydrochloride 20 mg, and Water for Injection, q.s.

*Penicillin G Potassium and Procaine Hydrochloride react to form Penicillin G Procaine.

ACTIONS: Penicillin G is an effective bactericide in the treatment of infections caused primarily by penicillin-sensitive organisms, such as Streptococcus equi and Erysipelothrix rhusiopathiae, as well as the gram negative organism Pasteurella multocida.

Pro-Pen-G Injection Indications

Penicillin G Procaine is indicated for the treatment of:

1. Cattle and sheep - bacterial pneumonia (shipping fever) caused by Pasteurella multocida.

2. Swine - erysipelas caused by Erysipelothrix rhusiopathiae.

3. Horses - strangles caused by Streptococcus equi.

Directions For Use

Restricted Drug (California) - Use Only as Directed.

The suspension should be administered by deep intramuscular injection within the fleshy muscles of the hip, rump, round or thigh, or into the neck, changing the site for each injection. Do not inject subcutaneously, into a blood vessel, or near a major nerve.

Use a 16 or 18 gauge needle, 1.5 inches long. The needle and syringe should be washed thoroughly before use. The needle and syringe should then be sterilized by placing in boiling water for 15 to 20 minutes. No vial should be entered more than 15 times with a 16 gauge needle or more than 40 times with an 18 gauge needle.

The injection site should be washed with soap and water and painted with a germicide such as tincture of iodine or 70% alcohol. The product should then be administered by using the following procedure:

1. Warm the vial to room temperature and shake thoroughly to ensure uniform suspension.

2. Wipe the rubber stopper on top of the vial with a piece of absorbent cotton soaked in 70% alcohol.

3. Inject air into the vial for easier withdrawal.

4. After filling the syringe, make sure that the needle is empty by pulling back the plunger of the syringe until a small air bubble appears. Then detach the needle from the syringe.

5. Insert the needle deep into the muscle, attach the syringe and withdraw the plunger slightly. If blood appears, withdraw the needle and insert it into a different location.

6. Inject the dose slowly. Do not massage the site of injection.

7. Not more than 10 mL should be injected in one location.

Daily treatment should be continued for at least 48 hours after temperature has returned to normal and all other signs of infection have subsided. Animals treated with Penicillin G Procaine Injectable Suspension should show noticeable improvement within 36 to 48 hours.

DOSAGE: The dosage for cattle, sheep, swine, and horses is 3000 units per pound of body weight, or 1.0 mL for each 100 pounds of body weight, once daily. Treatment should not exceed 7 days in non-lactating dairy and beef cattle, sheep, and swine, or 5 days in lactating dairy cattle. If no improvement is observed within 48 hours, consult your veterinarian.


1. Not for use in horses intended for food.

2. Milk that has been taken from animals during treatment and for 48 hours after the last treatment must not be used for food. The daily treatment schedule should not exceed 7 days of treatment in non-lactating dairy and beef cattle, sheep and swine, or 5 days in lactating dairy cattle.

3. The drug should be discontinued for the following time periods before treated animals are slaughtered for food: cattle - 4 days; sheep - 8 days; swine - 6 days; non-ruminating calves - 7 days.


Sensitivity reactions to penicillin and procaine, such as hives or respiratory distress, may occur in some animals. If such signs of sensitivity occur, stop medication and call your veterinarian. In some instances, particularly if respiratory distress is severe, immediate injection of epinephrine or antihistamine may be necessary.

As with any antibiotic preparation, prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If this condition is suspected, stop medication and consult your veterinarian.

Exceeding the highest recommended daily dosage of 3000 units per pound of body weight, administering at recommended levels for more than 7 consecutive days and/or exceeding 10 mL intramuscularly per injection site may result in antibiotic residues beyond the withdrawal time.


Penicillin G Procaine Injectable Suspension should be stored in a cold room at a temperature between 2° and 8°C (36°-46°F). Avoid freezing the product.

How Supplied

Penicillin G Procaine Injectable Suspension is supplied in 100-mL, 250-mL and 500-mL multiple-dose vials.


Manufactured For: Bimeda, Inc., Le Sueur, MN 56058

Bimeda, Inc. is a Division of Cross Vetpharm Group Ltd.

NADA 065-505, Approved by FDA

Pro-Pen-G is a Registered Trademark of Bimeda, Inc.


Net Contents:

Product No.


100 mL Sterile, Multiple Dose Vial (alternate method)



250 mL Sterile, Multiple Dose Vial (alternate method)



500 mL Sterile, Multiple Dose Vial (alternate method)



NAC No.: 13990667

Div. Cross Vetpharm Group, Ltd.

Telephone:   630-928-0361
Fax:   630-928-0362
Every effort has been made to ensure the accuracy of the Pro-Pen-G Injection information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2016 North American Compendiums. Updated: 2016-01-26