Marin For Cats

This page contains information on Marin For Cats for veterinary use.
The information provided typically includes the following:
  • Marin For Cats Indications
  • Warnings and cautions for Marin For Cats
  • Direction and dosage information for Marin For Cats

Marin For Cats

This treatment applies to the following species:
Manufacturer: Nutramax Labs.

Sold Only Through Veterinarians

Active Ingredients

Vitamin E (As d-α Tocopheryl Acetate)

50 IU

Silybin A+B

9 mg*

Other Ingredients:

Dicalcium phosphate, microcrystalline cellulose, natural tuna flavor, natural chicken flavor, phosphatidylcholine, silicon dioxide, and magnesium stearate.

* In a phosphatidylcholine complex to improve bioavailability.

Marin for Cats is a combination of silybin and vitamin E for veterinary use only. It is available as a single strength tablet.

Background

Silybin is the most biologically active component of an extract known as silymarin.1 Silybin/silymarin has been shown to have beneficial effects on liver function.2 Vitamin E, a membrane-associated antioxidant, helps protect the liver against oxidant injury.3

Purpose

Marin For Cats is specially formulated with silybin and vitamin E to provide comprehensive hepatic support.

Silybin/silymarin has many different mechanisms of action. In vitro and in vivo studies have shown that it protects against oxidative stress;4,5 promotes protein synthesis within hepatocytes,6 a mechanism for liver cell regeneration; inhibits leukotriene production,7 which can be beneficial as production of leukotrienes is a component of the inflammatory response; stimulates biliary flow and production of hepatoprotective bile salts (e.g., beta-muricholate and ursodeoxycholate);8 and increases levels of glutathione.9

Vitamin E, a membrane-associated antioxidant, benefits liver function because oxidant damage to hepatocytes can affect liver health. Vitamin E has been shown to reduce the oxidative damage to the hepatocyte mitochondrial membranes caused by hydrophobic bile salts (these bile salts build up in the liver when bile flow is impaired).3 Vitamin E use has been reported in cats for its antioxidant properties.10,11 Vitamin E has other actions separate from its antioxidant role that also help to support hepatic health.2

Pharmacokinetics

Silybin has low bioavailability.12 Marin, therefore, has been specially formulated to address this issue. It contains silybin in a complex with soybean phosphatidylcholine, resulting in superior absorption and bioavailability compared to silymarin or silybin administration alone.12-14 A study in dogs showed plasma silybin levels more than four times higher with administration of a silybin-phosphatidylcholine complex (SPC) than obtained with administration of silymarin alone (see Figure 1).15 Studies in rats showed that administration of the silybin-phosphatidylcholine complex was capable of reaching effective intracellular levels in liver microsomes not achieved with silybin administration alone.4

FIGURE 1

Plasma levels in dogs after oral administration of silymarin versus SPC (silybin-phosphatidylcholine complex). Each was given at the same amount based on silybin content (178 mg).15

Safety

There are no known drug interactions or contraindications to the use of silybin/silymarin in animals.16,17 While mild side effects, such as gastrointestinal upset, itching and headache, have been rarely reported in primates,16,18 side effects have not been noted in cats.16,17

Vitamin E is also well-tolerated in recommended amounts.3

Administration

Marin® For Cats is available as tablets that may be given orally or crumbled over the food. Recommended administration amounts are provided below.

DAILY ADMINISTRATION GUIDE

Body Weight

Marin for Cats

Up to 14 lbs

1 tablet

Over 14 lbs

2 tablets

Storage

Store in a cool dry place. Keep tablets in bottle until used.

Store in a cool, dry area out of direct sunlight.

Keep lid tightly secured to ensure freshness.

Keep bottle out of the reach of children.

This bottle contains (1) non-toxic desiccant to help preserve freshness and ensure the shelf life of the product.

REFERENCES

1. Kvasnicka F, Biba B, Sevcik R, et al. J Chromatogr A 2003;990:239-245.

2. Center SA. Veterinary Clinics of North America Small Animal Practice 2004;34:67-172.

3. Twedt DC. In Proceedings. 19th Annual ACVIM Forum 2001;610-612.

4. Comoglio A, Leonarduzzi G, Carini R, et al. Free Radic Res Commun 1990;11:109-115.

5. Bosisio E, Benelli C, Pirola O. Pharmacol Res 1992;25:147-154.

6. Sonnenbichler J, Zetl I. Hoppe Seylers Z Physiol Chem 1984;365:555-566.

7. Dehmlow C, Erhard J, de Groot H. Hepatology 1996;23:749-754.

8. Crocenzi FA, Pellegrino JM, Sanchez Pozzi EJ, et al. Biochem Pharmacol 2000;59:1015-1022.

9. Valenzuela A, Aspillaga M, Vial S, et al. Planta Med 1989;55:420-422.

10. Kaufman AC, Greene CE. J Am Vet Med Assoc 1993;202:628-630.

11. Hill AS, O'Neill S, Rogers QR, et al. Am J Vet Res 2001;62:370-374.

12. Morazzoni P, Magistretti MJ, Giachetti C, et al. Eur J Drug Metab Pharmacokinet 1992;17:39-44.

13. Schandalik R, Gatti G, Perucca E. Arzneimittelforschung 1992;42:964-968.

14. Barzaghi N, Crema F, Gatti G, et al. Eur J Drug Metab Pharmacokinet 1990;15:333-338.

15. Data on file, Nutramax Laboratories, Inc., Edgewood, MD 21040, USA 2006.

16. Sartor LL, Trepanier LA. Compend Contin Educ Vet Pract 2003;25:432-447.

17. Minton J. Compend Contin Educ Vet Pract 2004;26:631-632.

18. Flatland B. Compend Contin Educ Vet Pract 2003;25:514-524.

Nutramax Laboratories, Inc., 2208 Lakeside Boulevard, Edgewood, Maryland 21040

1-800-925-5187

nutramaxlabs.com

02-1007-04

60 Tablets

00-1026-02

NAC No.: 12910063

NUTRAMAX LABORATORIES, INC.
946 QUALITY DRIVE, LANCASTER, SC, 29720
Telephone:   803-289-6000
Toll-Free:   800-925-5187
Fax:   803-289-6001
Website:   www.nutramaxlabs.com
Every effort has been made to ensure the accuracy of the Marin For Cats information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-04-11

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