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Zioptan Side Effects

Generic Name: tafluprost ophthalmic

Note: This page contains side effects data for the generic drug tafluprost ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Zioptan.

It is possible that some side effects of Zioptan may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to tafluprost ophthalmic: ophthalmic solution

As well as its needed effects, tafluprost ophthalmic (the active ingredient contained in Zioptan) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking tafluprost ophthalmic, check with your doctor immediately:

Less common
  • Blurred vision
  • burning, dry, or itching eyes
  • decreased vision
  • eye discharge or excessive tearing
  • eye pain
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

Some tafluprost ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Headache
  • stinging or irritation of the eye
Less common
  • Cough
  • darker color of the eyelashes
  • dry eyes
  • increased growth of the eyelashes

For Healthcare Professionals

Applies to tafluprost ophthalmic: ophthalmic solution


Ocular side effects have included ocular stinging/irritation (7%), ocular pruritus including allergic conjunctivitis (5%), cataract (3%), dry eye (3%), ocular pain (3%), eyelash darkening (2%), growth of eyelashes (2%) and vision blurred (2%). Postmarketing side effects have included iritis and uveitis. In postmarketing use with prostaglandin analogs, periorbital and lid changes including deepening of the eyelid sulcus have been observed.[Ref]

Nervous system

Nervous system side effects have included headache.[Ref]


General side effects have included the common cold.[Ref]


Genitourinary side effects have included urinary tract infection.[Ref]


Respiratory side effects have included cough. Postmarketing side effects include exacerbation of asthma and dyspnea.[Ref]


1. "Product Information. Zioptan (tafluprost ophthalmic)." Merck & Company Inc, Whitehouse Station, NJ.

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