Zanosar Side Effects

Generic name: streptozocin

Note: This document contains side effect information about streptozocin. Some of the dosage forms listed on this page may not apply to the brand name Zanosar.

Some side effects of Zanosar may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to streptozocin: intravenous powder for injection

If you experience any of the following serious side effects from streptozocin (the active ingredient contained in Zanosar) contact your doctor immediately or seek emergency medical attention:

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• kidney damage (little or no urine production, blood in the urine);

• liver problems (changes in blood test results, abdominal pain, yellowing of the skin or eyes, decreased appetite, nausea);

• decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection); or

• severe nausea, vomiting, loss of appetite, or diarrhea.

In some cases, secondary cancers have been reported to occur during and following treatment with streptozocin. Talk to your doctor about the risks and benefits of this medication.

Other, less serious side effects may be more likely to occur. Continue taking streptozocin and talk to your doctor if you experience:

• mild nausea, vomiting, loss of appetite, or diarrhea;

• drowsiness;

• confusion;

• depression; or

• swelling, redness, burning, or tenderness at the injection site.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to streptozocin: intravenous powder for injection

Renal

Renal toxicity is dose-related and cumulative. Adequate hydration may help reduce the risk of nephrotoxicity to renal tubular epithelium by decreasing renal and urinary concentration of the drug and its metabolites.

Renal side effects have included severe and sometimes fatal renal toxicity, azotemia, anuria, hypophosphatemia, glycosuria, and renal tubular acidosis. A case of chronic renal failure has also been reported.

Hematologic

Hematologic side effects have included fatal hematologic toxicity with substantial reductions in leukocyte and platelet counts. In most cases, hematologic toxicity only involves mild decreases in hematocrit values.

Gastrointestinal

Severe nausea and vomiting have occasionally required the discontinuation of therapy.

Gastrointestinal side effects have included severe nausea and vomiting. Diarrhea has also been reported.

Metabolic

Abnormalities of glucose tolerance have generally been reversible.

Metabolic side effects have included mild to moderate abnormalities of glucose tolerance. Insulin shock with hypoglycemia has also been reported.

Local

In most cases, local effects have been reported to resolve either the same day or within a few days.

Local side effects following extravasation have included erythema, burning, and tenderness.

Hepatic

Hepatic side effects have included hypoalbuminemia and elevated SGOT and LDH levels.

Genitourinary

Genitourinary side effects have included two cases of nephrogenic diabetes insipidus.

One case of nephrogenic diabetes insipidus was reported to have had a spontaneous recovery while the second case responded to indomethacin.

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