Pill Identifier App

Trusopt Side Effects

Generic Name: dorzolamide ophthalmic

Note: This document contains side effect information about dorzolamide ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Trusopt.

Some side effects of Trusopt may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to dorzolamide ophthalmic: ophthalmic solution

Along with its needed effects, dorzolamide ophthalmic (the active ingredient contained in Trusopt) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dorzolamide ophthalmic:

More common
  • Burning, stinging, or discomfort when medicine is applied
  • itching, redness, swelling, or other sign of the eye or eyelid irritation
Less common
  • Burning, dry, or itching eyes
  • discharge from the eye
  • excessive tearing
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • Blood in the urine
  • blurred vision
  • nausea or vomiting
  • pain in the side, back, or abdomen
  • skin rash
  • tearing
Incidence not known
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • change in vision
  • chills
  • cough
  • diarrhea
  • difficult or labored breathing
  • flashes of light
  • floaters in vision
  • hives or welts
  • itching skin
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • noisy breathing
  • redness of the skin
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur while taking dorzolamide ophthalmic:

Symptoms of overdose
  • Confusion
  • irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • seizures
  • trembling
  • weakness and heaviness of the legs

Some side effects of dorzolamide ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bitter taste
  • feeling of something in the eye
Less common
  • Changes in color vision
  • difficulty seeing at night
  • dryness of the eyes
  • eyelid reactions
  • headache
  • increased sensitivity of the eyes to sunlight
Incidence not known
  • Bloody nose
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in distance vision
  • difficulty in focusing the eyes
  • dizziness
  • dry mouth
  • eyelid crusting
  • lack or loss of strength
  • scaling of the skin
  • severe redness, soreness, or swelling of the skin

For Healthcare Professionals

Applies to dorzolamide ophthalmic: ophthalmic solution


Foreign body sensation has been reported due to formation of precipitate on the tip of the dropper bottle, which entered the eye during instillation of the eye drops.

A 76-year-old woman with a 7-year history of open-angle glaucoma developed an abrupt choroidal detachment in the surgically untreated eye following 2 doses of dorzolamide. Systemic medications included verapamil and hydrochlorothiazide. Ocular medications consisted of timolol 0.5% twice daily to both eyes for the past 7 years. This reaction may have been a result of hypotony or an idiosyncratic reaction to the sulfa-containing agent, dorzolamide.

Ocular side effects have included burning and stinging upon instillation which has been reported in approximately 33% of patients receiving dorzolamide ophthalmic drops. Superficial punctate epithelial erosions occurred in approximately 15% of patients. Evidence of local allergic reaction to dorzolamide was present in approximately 10% of patients. Other ocular events seen in 1% to 5% of patients were conjunctivitis, lid reactions, dryness, photophobia, tearing, and blurred vision. Transient myopia, ocular pain, iridocyclitis, and eyelid crusting have been reported rarely. Slight increases in central corneal thickness have been reported in patients with cornea guttata after short-term (1 day) use of dorzolamide. A single case of abrupt choroidal detachment in a surgically untreated eye has been reported.


Approximately 25% of patients have reported a bitter taste following administration.


Hypersensitivity has occurred in approximately 10% of patients. Reactions reported include local ocular reaction, angioedema, pruritus, urticaria, and bronchospasm. Skin rashes and contact dermatitis have also been reported.


Dermatologic side effects have included skin rashes and throat irritation. Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported rarely.

Nervous system

Nervous system side effects have included headache, asthenia, paresthesia and dizziness.


Gastrointestinal side effects have included bitter taste (25%), nausea (infrequent), throat irritation (<1%), and dry mouth (<1%).


Genitourinary side effects have included urolithiasis.


Respiratory side effects have included rare reports of bronchospasm, which may be a symptom of hypersensitivity.


Hematologic side effects have included epistaxis.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.