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Trusopt Side Effects

Generic Name: dorzolamide ophthalmic

Note: This page contains side effects data for the generic drug dorzolamide ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Trusopt.

It is possible that some side effects of Trusopt may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to dorzolamide ophthalmic: ophthalmic solution

As well as its needed effects, dorzolamide ophthalmic (the active ingredient contained in Trusopt) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking dorzolamide ophthalmic, check with your doctor immediately:

More common
  • Burning, stinging, or discomfort when medicine is applied
  • itching, redness, swelling, or other sign of the eye or eyelid irritation
Less common
  • Burning, dry, or itching eyes
  • discharge from the eye
  • excessive tearing
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • Blood in the urine
  • blurred vision
  • nausea or vomiting
  • pain in the side, back, or abdomen
  • skin rash
  • tearing
Incidence not known
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • change in vision
  • chills
  • cough
  • diarrhea
  • difficult or labored breathing
  • flashes of light
  • floaters in vision
  • hives or welts
  • itching skin
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • noisy breathing
  • redness of the skin
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • tightness in the chest
  • unusual tiredness or weakness

If any of the following symptoms of overdose occur while taking dorzolamide ophthalmic, get emergency help immediately:

Symptoms of overdose
  • Confusion
  • irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • seizures
  • trembling
  • weakness and heaviness of the legs

Some dorzolamide ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Bitter taste
  • feeling of something in the eye
Less common
  • Changes in color vision
  • difficulty seeing at night
  • dryness of the eyes
  • eyelid reactions
  • headache
  • increased sensitivity of the eyes to sunlight
Incidence not known
  • Bloody nose
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in distance vision
  • difficulty in focusing the eyes
  • dizziness
  • dry mouth
  • eyelid crusting
  • lack or loss of strength
  • scaling of the skin
  • severe redness, soreness, or swelling of the skin

For Healthcare Professionals

Applies to dorzolamide ophthalmic: ophthalmic solution


The most commonly reported side effects were ocular burning, stinging, or discomfort, and bitter taste.[Ref]


Very common (10% or more): Superficial punctate keratitis (up to 15%), burning/stinging
Common (1% to 10%): Tearing, conjunctivitis, eyelid inflammation, eye itching, eyelid irritation, blurred vision
Uncommon (0.1% to 1%): Iridocyclitis
Rare (less than 0.1%): Irritation, pain, eyelid crusting, transient myopia, corneal edema, ocular hypotony, choroidal detachment following filtration surgery[Ref]


Very common (10% or more): Ocular allergic reaction (10%)
Rare (less than 0.1%): Signs and symptoms of local reactions (palpebral reactions) and systemic allergic reactions including angioedema, urticaria, pruritus, rash, shortness of breath, bronchospasm[Ref]


Rare (less than 0.1%): Urolithiasis[Ref]


Rare (less than 0.1%): Epistaxis
Frequency not reported: Dyspnea[Ref]


Uncommon (0.1% to 1%): Contact dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis
Rare (less than 0.1%): Skin rash[Ref]

Nervous system

Very common (10% or more): Biter taste (up to 25%)
Frequency not reported: Headache[Ref]


Common (1% to 10%): Nausea
Rare (less than 0.1%): Throat irritation, dry mouth[Ref]


Common (1% to 10%): Asthenia/fatigue[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Trusopt (dorzolamide ophthalmic)." Merck & Co, Inc, West Point, PA.

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