SymlinPen 120 Side Effects

Generic Name: pramlintide

Note: This document contains side effect information about pramlintide. Some of the dosage forms listed on this page may not apply to the brand name SymlinPen 120.

Some side effects of SymlinPen 120 may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to pramlintide: subcutaneous solution

Along with its needed effects, pramlintide (the active ingredient contained in SymlinPen 120) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pramlintide:

More common
  • Anxiety
  • blurred vision
  • chills
  • cold sweats
  • coma
  • confusion
  • cool pale skin
  • cough
  • depression
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • headache
  • hives
  • increased hunger
  • itching
  • nausea
  • nervousness
  • nightmares
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • shakiness
  • shortness of breath
  • skin rash
  • slurred speech
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing

Some side effects of pramlintide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Difficulty with moving
  • inflicted injury
  • loss of appetite
  • muscle pain or stiffness
  • pain in the joints
  • stomach pain
  • vomiting
  • weight loss
Less common
  • Body aches or pain
  • congestion
  • dryness or soreness of the throat
  • fever
  • hoarseness
  • runny nose
  • tender, swollen glands in the neck
  • trouble in swallowing
  • voice changes

For Healthcare Professionals

Applies to pramlintide: subcutaneous solution


Metabolic side effects have included hypoglycemia. Severe hypoglycemia (requiring assistance in ingestion of oral carbohydrate, administration of glucagon, intravenous glucose, or other medical intervention) was reported in up to 8.2% of patients in long-term studies.


Gastrointestinal side effects have included nausea, anorexia, vomiting, and abdominal pain.

Nervous system

Nervous system side effects have included headache and dizziness.


Musculoskeletal side effects have included arthralgia and fatigue.


Respiratory side effects have included cough and pharyngitis.


Hypersensitivity side effects have included allergic reactions.


General side effects have included injury.


Local side effects have included post marketing reports of injection site reactions.

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