Pramlintide Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Diabetes Type 1

Initial dose:
15 micrograms subcutaneously immediately prior to major meals (250 or more Kcal or containing 30 or more grams of carbohydrate).
Reduce preprandial rapid acting or short-acting insulin dosages, including fixed mix insulins (e.g., 70/30) by 50%.
Increase dose to next increment (30 micrograms, 45 micrograms, or 60 micrograms) when no clinically significant nausea has occurred for at least 3 days.

Usual Adult Dose for Diabetes Type 2

For insulin using Diabetes Type II:
Initial dose:
60 micrograms subcutaneously immediately prior to major meals (250 or more Kcal or containing 30 or more grams of carbohydrate).
Reduce preprandial rapid acting or short-acting insulin dosages, including fixed mix insulins (e.g., 70/30) by 50%.
Increase dose to 120 micrograms when no clinically significant nausea has occurred for 3 to 7 days.

Renal Dose Adjustments

No dosage adjustment is need in moderate to severe renal impairment (creatinine clearance >20 mL/min)

Liver Dose Adjustments

Hepatic dysfunction is not expected to affect blood concentrations of pramlintide.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

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