Suprane Side Effects

Generic name: desflurane

Note: This document contains side effect information about desflurane. Some of the dosage forms listed on this page may not apply to the brand name Suprane.

Some side effects of Suprane may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to desflurane: inhalation liquid, inhalation solution

Along with its needed effects, desflurane (the active ingredient contained in Suprane) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects of desflurane may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Coughing
• nausea or vomiting

• Dizziness
• headache
• irritated or red eyes
• nervousness and restlessness
• sore throat

For Healthcare Professionals

Applies to desflurane: inhalation liquid

Respiratory

Respiratory side effects including coughing (34%), breathholding (up to 30%), apnea (15%), increased secretions, laryngospasm, oxyhemoglobin desaturation, pharyngitis, increased cough, dyspnea, respiratory arrest, respiratory failure, respiratory distress, bronchospasm, hemoptysis, and hypoxia have been reported.

Gastrointestinal

Gastrointestinal side effects including nausea (27%), vomiting (16%), acute pancreatitis, and abdominal pain have been reported.

Cardiovascular

Cardiovascular side effects including bradycardia, hypertension, nodal arrhythmia, tachycardia, arrhythmia, bigeminy, abnormal electrocardiogram, myocardial ischemia, vasodilation, hemorrhage, cardiac arrest, Torsade de pointes, ventricular failure, ventricular hypokinesia, malignant hypertension, hypotension,
and myocardial infarct have been reported.

Nervous system

Nervous system side effects including increased salivation, agitation, convulsion, and dizziness have been reported.

Hepatic

Hepatic side effects including hepatitis, hepatic failure, hepatic necrosis, cytolytic hepatitis, cholestasis, jaundice, abnormal hepatic function, liver disorder, increased transaminases, increased alanine aminotransferase, and increased aspartate aminotransferase
have been reported.

General

General side effects including shock, malignant hyperthermia, asthenia, malaise, headache, and fever have been reported.

Ocular

Ocular side effects including conjunctivitis (conjunctival hyperemia) and ocular icterus have been reported.

Metabolic

Metabolic side effects including hyperkalemia, hypokalemia, metabolic acidosis, and increased creatinine phosphokinase have been reported.

Musculoskeletal

Musculoskeletal side effects including myalgia and rhabdomyolysis have been reported.

Dermatologic

Dermatologic side effects including urticaria, erythema, and pruritus have been reported.

Hematologic

Hematologic side effects including coagulopathy have been reported.

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