Simbrinza Side Effects

Generic Name: brimonidine / brinzolamide ophthalmic

Note: This page contains side effects data for the generic drug brimonidine / brinzolamide ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Simbrinza.

It is possible that some side effects of Simbrinza may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to brimonidine / brinzolamide ophthalmic: ophthalmic suspension

As well as its needed effects, brimonidine / brinzolamide ophthalmic may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking brimonidine / brinzolamide ophthalmic, check with your doctor immediately:

More common
  • Blurred vision
  • discoloration of the white part of the eye
  • eye irritation or redness
Less common
  • Decreased vision
  • eye pain
  • eyes sensitive to light
  • red, sore eyes
Rare
  • Burning, dry, or itching eyes
  • discharge or excessive tearing
  • hives or welts
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • skin rash
Incidence not known
  • Chest pain or discomfort
  • constricted, pinpoint, or small pupils (black part of the eye)
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • hoarseness
  • irritation
  • itching
  • joint pain, stiffness, or swelling
  • lightheadedness, dizziness, or fainting
  • redness of the skin
  • shortness of breath
  • slow or irregular heartbeat
  • swelling of the eyelids, face, lips, hands, or feet
  • tearing
  • throbbing pain
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual tiredness

If any of the following symptoms of overdose occur while taking brimonidine / brinzolamide ophthalmic, get emergency help immediately:

Symptoms of overdose
  • Confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • seizures
  • sweating
  • trembling
  • weakness and heaviness of the legs

Some brimonidine / brinzolamide ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Burning and stinging sensation
  • change in color vision
  • change in taste
  • difficulty seeing at night
  • drowsiness
  • feeling of having something in the eye
  • headache
  • increase in blood flow to the whites of the eyes
  • increased sensitivity of the eyes to sunlight
  • lack or loss of strength
  • loss of taste
  • paleness of the eye or inner lining of the eyelid
  • redness and tiny bumps on the lining of the eyelid
Less common
  • Dry eyes
  • dry mouth
  • muscle pain
  • runny nose
  • sneezing
  • stuffy nose
  • trouble sleeping
Rare
  • Acid or sour stomach
  • belching
  • body aches or pain
  • congestion
  • cough
  • crusting in the corner of the eye
  • diarrhea
  • double vision
  • dryness or soreness of the throat
  • excessive muscle tone
  • hair loss or thinning of the hair
  • heartburn
  • hoarseness
  • indigestion
  • muscle stiffness
  • muscle tension or tightness
  • nausea
  • stomach discomfort, upset, or pain
  • tender, swollen glands in the neck
  • tightness in the chest
  • voice changes

For Healthcare Professionals

Applies to brimonidine / brinzolamide ophthalmic: ophthalmic suspension

Cardiovascular

Brinzolamide:
Common (1% to 10%): Hyperemia
Uncommon (0.1% to 1%): Chest pain

Brimonidine:
Frequency not reported: Hypertension, palpitations/arrhythmias
Postmarketing reports: Bradycardia, tachycardia[Ref]

Dermatologic

Brinzolamide:
Common (1% to 10%): Dermatitis

Brimonidine:
Postmarketing reports: Skin reactions (erythema, eyelid pruritus, rash, and vasodilation)[Ref]

Gastrointestinal

Brinzolamide:
Common (1% to 10%): Bitter, sour or unusual taste
Uncommon (less than 1%): Diarrhea, dry mouth, dyspepsia, nausea

Brimonidine:
Very common (10% or more): Oral dryness
Common (1% to 10%): Gastrointestinal symptoms
Frequency not reported: Abnormal taste
Postmarketing reports: Nausea[Ref]

General

The most frequently reported side effects included blurred vision, eye irritation, dysgeusia, dry mouth, eye allergy

Postmarketing reactions reported in infants receiving brimonidine ophthalmic solutions include apnea, bradycardia, coma, hypotension, hypothermia, hypotonia, lethargy, pallor, respiratory depression, somnolence. Brimonidine caused somnolence (50% to 83%) and decreased alertness in patients 2 to 6 years old.

Hypersensitivity

Brinzolamide:
Uncommon (less than 1%): Allergic reactions

Brimonidine:
Postmarketing reports: Hypersensitivity[Ref]

Musculoskeletal

Brimonidine:
Common (1% to 10%): Muscular pain[Ref]

Nervous system

Brinzolamide:
Common (1% to 10%): Headache
Uncommon (less than 1%): Dizziness, hypertonia

Brimonidine:
Very common (10% or more): Headache, drowsiness
Common (1% to 10%): Dizziness
Frequency not reported: Insomnia, syncope[Ref]

Ocular

Brinzolamide:
Common (1% to 10%): Blurred vision, blepharitis, dry eye, foreign body sensation, ocular discharge, ocular discomfort, ocular keratitis, ocular pain, ocular pruritus
Uncommon (less than 1%): Conjunctivitis, diplopia, eye fatigue, keratoconjunctivitis, keratopathy, lid margin crusting or sticky sensation, tearing

Brimonidine:
Very common (10% or more): Ocular hyperemia, burning and stinging, blurring, foreign body sensation, conjunctival follicles, ocular allergic reactions, ocular pruritus
Common (1% to 10%): Corneal staining/erosion, photophobia, eyelid erythema, ocular ache/pain, ocular dryness, tearing, eyelid edema, conjunctival edema, blepharitis, ocular irritation, conjunctival blanching, abnormal vision
Frequency not reported: Lid crusting, conjunctival hemorrhage, conjunctival discharge
Postmarketing reports: Iritis, keratoconjunctivitis sicca, miosis[Ref]

Other

Brimonidine:
Common (1% to 10%): Asthenia, fatigue[Ref]

Psychiatric

Brimonidine:
Frequency not reported: Depression, anxiety[Ref]

Renal

Brinzolamide:
Uncommon (less than 1%): Kidney pain[Ref]

Respiratory

Brinzolamide:
Uncommon (less than 1%): Dyspnea, pharyngitis

Brimonidine:
Common (1% to 10%): Upper respiratory symptoms
Frequency not reported: Nasal dryness[Ref]

References

1. "Product Information. Simbrinza (brimonidine-brinzolamide ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.

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