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Simbrinza Side Effects

Generic name: brimonidine / brinzolamide ophthalmic

Medically reviewed by Drugs.com. Last updated on Sep 22, 2023.

Note: This document provides detailed information about Simbrinza Side Effects associated with brimonidine / brinzolamide ophthalmic. Some dosage forms listed on this page may not apply specifically to the brand name Simbrinza.

Applies to brimonidine/brinzolamide ophthalmic: ophthalmic suspension.

Serious side effects of Simbrinza

Along with its needed effects, brimonidine/brinzolamide ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brimonidine / brinzolamide ophthalmic:

More common

  • blurred vision
  • discoloration of the white part of the eye
  • eye irritation or redness

Less common

  • decreased vision
  • eye pain
  • eyes sensitive to light
  • red, sore eyes

Rare

  • burning, dry, or itching eyes
  • discharge or excessive tearing
  • hives or welts
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • skin rash

Incidence not known

  • chest pain, discomfort, or tightness
  • constricted, pinpoint, or small pupils (black part of the eye)
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • hoarseness
  • irritation
  • itching
  • joint pain, stiffness, or swelling
  • lightheadedness, dizziness, or fainting
  • redness of the skin
  • slow or irregular heartbeat
  • swelling of the eyelids, face, lips, hands, or feet
  • tearing
  • throbbing pain
  • trouble breathing or swallowing
  • unusual tiredness
  • blistering, peeling, or loosening of the skin
  • chills
  • cough
  • diarrhea
  • muscle pain
  • red irritated eyes
  • red skin lesions, often with a purple center
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips

Get emergency help immediately if any of the following symptoms of overdose occur while taking brimonidine / brinzolamide ophthalmic:

Symptoms of overdose

Other side effects of Simbrinza

Some side effects of brimonidine / brinzolamide ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • burning and stinging sensation
  • change in color vision
  • change in taste
  • difficulty seeing at night
  • drowsiness
  • feeling of having something in the eye
  • headache
  • increase in blood flow to the whites of the eyes
  • increased sensitivity of the eyes to sunlight
  • lack or loss of strength
  • loss of taste
  • paleness of the eye or inner lining of the eyelid
  • redness and tiny bumps on the lining of the eyelid

Less common

  • dry eyes
  • dry mouth
  • muscle pain
  • sneezing
  • stuffy or runny nose
  • trouble sleeping

Rare

  • acid or sour stomach
  • belching
  • body aches or pain
  • cough
  • crusting in the corner of the eye
  • double vision
  • dryness or soreness of the throat
  • excessive muscle tone
  • hair loss or thinning of the hair
  • heartburn
  • hoarseness
  • indigestion
  • muscle stiffness, tension, or tightness
  • nausea
  • stomach discomfort, upset, or pain
  • tender, swollen glands in the neck
  • voice changes

For Healthcare Professionals

Applies to brimonidine / brinzolamide ophthalmic: ophthalmic suspension.

General

The most commonly reported side effects were blurred vision, ocular hyperemia, eye allergy, dry mouth, and dysgeusia.[Ref]

Dermatologic

Gastrointestinal

Cardiovascular

Hypersensitivity

Musculoskeletal

Nervous system

Ocular

Other

Psychiatric

Renal

Respiratory

Genitourinary

Hematologic

Hepatic

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. Cerner Multum, Inc. "Australian Product Information."

3. (2013) "Product Information. Simbrinza (brimonidine-brinzolamide ophthalmic)." Alcon Laboratories Inc

Further information

Simbrinza side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.