Primaquine Side Effects
Some side effects of primaquine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to primaquine: oral tablet
Stop taking primaquine and seek emergency medical attention if you experience an allergic reaction (flushing; swelling of your lips, tongue, or face, difficulty breathing; closing of your throat; vision problems; a rash; or itching).
Notify your doctor if you experience darkening of your urine.
Nausea, stomach pain or upset, vomiting, and loss of appetite may also occur during therapy.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to primaquine: compounding powder, oral tablet
The severity of hemolytic anemia in patients with G-6-PD deficiency treated with primaquine is dependent upon the dose given and the patient's ethnic background. In American and African Blacks, hemolytic anemia is generally mild and self-limiting, and lower prophylactic doses of primaquine may be tolerated. In patients of Mediterranean and some Oriental origins, the hemolytic anemia may be severe. Most patients with hemolytic anemia present with dark urine, jaundice, vomiting, and headache.
Hematologic side effects have included hemolytic anemia (if administered to patients with glucose-6-phosphate dehydrogenase deficiency [G-6-PD]) and methemoglobinemia in patients with nicotinamide adenine dinucleotide (NADH) methemoglobin reductase deficiency. Leukopenia, mild anemia, and leukocytosis have occasionally been reported.
Gastrointestinal side effects have included nausea, vomiting, abdominal cramps, and epigastric distress.
Hypersensitivity skin rashes have been reported in approximately 50% of AIDS patients being treated with primaquine and clindamycin for Pneumocystis carinii pneumonia.
More primaquine resources
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