Primaquine Side Effects
Some side effects of primaquine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to primaquine: oral tablet
Along with its needed effects, primaquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking primaquine:More common
- Back, leg, or stomach pains
- dark urine
- loss of appetite
- pale skin
- unusual tiredness or weakness
- Bluish fingernails, lips, or skin
- difficulty breathing
- dizziness or lightheadedness
- Sore throat and fever
Some side effects of primaquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- nausea or vomiting
For Healthcare Professionals
Applies to primaquine: compounding powder, oral tablet
The severity of hemolytic anemia in patients with G-6-PD deficiency treated with primaquine is dependent upon the dose given and the patient's ethnic background. In American and African Blacks, hemolytic anemia is generally mild and self-limiting, and lower prophylactic doses of primaquine may be tolerated. In patients of Mediterranean and some Oriental origins, the hemolytic anemia may be severe. Most patients with hemolytic anemia present with dark urine, jaundice, vomiting, and headache.
Hematologic side effects have included hemolytic anemia (if administered to patients with glucose-6-phosphate dehydrogenase deficiency [G-6-PD]) and methemoglobinemia in patients with nicotinamide adenine dinucleotide (NADH) methemoglobin reductase deficiency. Leukopenia, mild anemia, and leukocytosis have occasionally been reported.
Gastrointestinal side effects have included nausea, vomiting, abdominal cramps, and epigastric distress.
Hypersensitivity skin rashes have been reported in approximately 50% of AIDS patients being treated with primaquine and clindamycin for Pneumocystis carinii pneumonia.
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