Primaquine Side Effects
It is possible that some side effects of primaquine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to primaquine: oral tablet
As well as its needed effects, primaquine may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking primaquine, check with your doctor immediately:More common
- Back, leg, or stomach pains
- dark urine
- loss of appetite
- pale skin
- unusual tiredness or weakness
- Bluish fingernails, lips, or skin
- difficulty breathing
- dizziness or lightheadedness
- Sore throat and fever
Some primaquine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- nausea or vomiting
For Healthcare Professionals
Applies to primaquine: compounding powder, oral tablet
The severity of hemolytic anemia in patients with G-6-PD deficiency treated with primaquine is dependent upon the dose given and the patient's ethnic background. In American and African Blacks, hemolytic anemia is generally mild and self-limiting, and lower prophylactic doses of primaquine may be tolerated. In patients of Mediterranean and some Oriental origins, the hemolytic anemia may be severe. Most patients with hemolytic anemia present with dark urine, jaundice, vomiting, and headache.
Hematologic side effects have included hemolytic anemia (if administered to patients with glucose-6-phosphate dehydrogenase deficiency [G-6-PD]) and methemoglobinemia in patients with nicotinamide adenine dinucleotide (NADH) methemoglobin reductase deficiency. Leukopenia, mild anemia, and leukocytosis have occasionally been reported.
Gastrointestinal side effects have included nausea, vomiting, abdominal cramps, and epigastric distress.
Hypersensitivity skin rashes have been reported in approximately 50% of AIDS patients being treated with primaquine and clindamycin for Pneumocystis carinii pneumonia.
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