Primaquine use while Breastfeeding
Primaquine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Little information is available on the use of primaquine during breastfeeding. If it is required, the mother and infant should be tested for G6PD deficiency before primaquine is given to a woman who is breastfeeding. United Kingdom malaria treatment guidelines recommend that primaquine be avoided in nursing mothers with malaria and that weekly chloroquine 500 mg be given until breastfeeding is completed. The Centers for Disease Control and Prevention guidelines state that primaquine may be used in breastfeeding mothers and infants with normal G6PD levels.
In general, very small amounts of antimalarial drugs are excreted in the breast milk of lactating women. Because the quantity of antimalarial drugs transferred in breast milk is insufficient to provide adequate protection against malaria, infants who require chemoprophylaxis must receive the recommended dosages of antimalarial drugs.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Preliminary results from a trial using primaquine 0.5 mg/kg daily to treat malaria in mothers nursing infants 28 days of age and older has found no drug-related adverse effects.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
1. Lalloo DG, Shingadia D, Bell DJ et al. UK Malaria Treatment Guidelines 2016. J Infect. 2016. PMID: 26880088
2. Centers for Disease Control and Prevention. CDC Health Information for International Travel 2016. New York: Oxford University Press . 2016. wwwnc.cdc.gov/travel/page/yellowbook-home-2014
3. Gilder ME, Tarning J, Lindeganullrdh N H et al. A study of the pharmacokinetics of primaquine in lactating women and breastfed infants for the radical treatment of uncomplicated maternal plasmodium vivax. Am J Trop Med Hyg. 2014;91:587. Abstract. http://www.ajtmh.org/content/91/5_Suppl_1/534.full.pdf+html
CAS Registry Number
LactMed Record Number
Last Revision Date
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.