Nitazoxanide Side Effects

Some side effects of nitazoxanide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to nitazoxanide: oral powder for reconstitution, oral tablet

Stop taking nitazoxanide and seek emergency medical attention if you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take the medication and talk to your doctor if you experience

• abdominal pain;

• nausea;

• diarrhea;

• vomiting; or

• headache.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

For Healthcare Professionals

Applies to nitazoxanide: oral powder for reconstitution, oral tablet

Gastrointestinal

Gastrointestinal side effects have included abdominal pain (6.6% to 7.8%), diarrhea (2.1% to 4.2%), and nausea (3%). Side effects occurring in less than 1% of patients have included vomiting, anorexia, flatulence, dyspepsia, constipation, dry mouth, and thirst.

The incidence of gastrointestinal side effects may be dose related. Abdominal pain, diarrhea and discolored urine occurred more often in subjects receiving higher doses (1 gram twice daily).

Nervous system

Nervous system side effects have included headache (3.1%). Dizziness, somnolence, insomnia, tremor, and hypesthesia have been reported by less than 1% of the patients.

Other

Adverse effects affecting the body as a whole have included asthenia, fever, pain (pelvic/back), flu syndrome, ear ache, and chills in less than 1% of patients.

Metabolic

Metabolic side effects have included increased creatinine and SGPT in less than 1% of patients.

Dermatologic

Dermatologic side effects have included pruritus, rash, and sweat in less than 1% of patients.

Ocular

Ocular side effects have included pale yellow eye discoloration (<1%).

Respiratory

Respiratory side effects have included epistaxis, rhinitis, lung disease, and pharyngitis.

Genitourinary

Genitourinary side effects have included discolored urine, dysuria, amenorrhea, metrorrhagia, and edema labia.

General

In general, side effects have been mild and transient in nature. The most frequent side effects have included abdominal pain, diarrhea, vomiting, and headache, and the rates of occurrence were not significantly different from placebo.

Musculoskeletal

Musculoskeletal side effects have included myalgia, leg cramps, and spontaneous bone fracture.

Cardiovascular

Cardiovascular side effects have included tachycardia, syncope, and hypertension.

Hematologic

Hematologic side effects have included anemia and leukocytosis.

Renal

Renal side effects have included kidney pain.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.