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Navane Side Effects

Generic Name: thiothixene

Note: This page contains side effects data for the generic drug thiothixene. It is possible that some of the dosage forms included below may not apply to the brand name Navane.

It is possible that some side effects of Navane may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to thiothixene: oral capsule, oral liquid, oral solution, oral tablet

As well as its needed effects, thiothixene (the active ingredient contained in Navane) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking thiothixene, check with your doctor immediately:

  • Cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing
Incidence not known
  • Abdominal or stomach pain
  • back, leg, or stomach pains
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • bloody, black, or tarry stools
  • blurred vision
  • chest pain
  • chills
  • clay-colored stools
  • confusion
  • convulsions
  • cough or hoarseness
  • dark urine
  • difficulty with breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • fever with or without chills
  • general body swelling
  • general feeling of tiredness or weakness
  • headache
  • high fever
  • high or low blood pressure
  • inability to move the eyes
  • inability to sit still
  • increased blinking or spasms of the eyelid
  • increased sweating
  • lightheadedness
  • lip smacking or puckering
  • loss of appetite
  • loss of balance control
  • loss of bladder control
  • lower back or side pain
  • mask-like face
  • nausea or vomiting
  • need to keep moving
  • nosebleeds
  • overactive reflexes
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • puffing of the cheeks
  • rapid or worm-like movements of the tongue
  • rapid weight gain
  • restlessness
  • seizures
  • severe muscle stiffness
  • shuffling walk
  • slowed movements
  • slurred speech
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sticking out of the tongue
  • sweating
  • swollen glands
  • tic-like (jerky) movements of the head, face, mouth, and neck
  • tingling of the hands or feet
  • tiredness
  • trembling and shaking of the fingers and hands
  • trouble with breathing, speaking, or swallowing
  • uncontrolled chewing movements
  • uncontrolled movements of the arms and legs
  • uncontrolled twisting movements of the neck, trunk, arms, or legs
  • unexplained bleeding or bruising
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual facial expressions
  • unusual weight gain or loss
  • unusually pale skin
  • vomiting of blood
  • yellowing of the eyes or skin

If any of the following symptoms of overdose occur while taking thiothixene, get emergency help immediately:

Symptoms of overdose
  • Change in consciousness
  • depression
  • drowsiness
  • loss of consciousness
  • sudden jerky movements of the body

Some thiothixene side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known
  • Absent, missed, or irregular menstrual periods
  • anxiety
  • constipation
  • decreased interest in sexual intercourse
  • diarrhea
  • dry mouth
  • extreme thirst
  • hives or welts
  • hyperventilation
  • inability to have or keep an erection
  • increased appetite
  • increased sensitivity of the skin to sunlight
  • increased sweating
  • increased thirst
  • increased weight
  • irritability
  • loss in sexual ability, desire, drive, or performance
  • menstrual changes
  • nervousness
  • redness or other discoloration of the skin
  • severe sunburn
  • sleeplessness
  • stopping of menstrual bleeding
  • stuffy nose
  • swelling of the breasts or unusual milk production
  • trouble with sleeping
  • unable to sleep
  • watering of mouth

For Healthcare Professionals

Applies to thiothixene: intramuscular powder for injection, oral capsule, oral concentrate

Nervous system

Frequency not reported: Tardive dyskinesia, extrapyramidal symptoms (e.g., pseudoparkinsonism, akathisia, dystonia), drowsiness, sedation, restlessness, agitation, insomnia, seizures, paradoxical exacerbation of psychotic symptoms[Ref]


Frequency not reported: Hyperprolactinemia, lactation, menstrual irregularities, moderate breast enlargement, galactorrhea, amenorrhea, gynecomastia, impotence[Ref]


Frequency not reported: Tachycardia, hypotension, lightheadedness, syncope, nonspecific ECG changes[Ref]


-As this drug has certain chemical and pharmacological similarities to the phenothiazines, all the side effects and toxicity associated with phenothiazines should be considered when this drug is used.
-Side effects of phenothiazines (not reported in this drug) include: cerebral edema, cerebrospinal fluid abnormalities, liver damage (jaundice, biliary stasis), eosinophilia, hemolytic anemia, pancytopenia, thrombocytopenic purpura, neutropenia, agranulocytosis, hyperreflexia (in infants whose mothers received phenothiazines), hypoglycemia, hyperglycemia, glycosuria, exfoliative dermatitis, contact dermatitis (in nursing personnel), miosis, mydriasis, adynamic ileus, and systemic lupus erythematosus-like syndrome.[Ref]


Rare (less than 0.1%): Anaphylaxis
Frequency not reported: Allergic reactions (rash, pruritus, urticaria, photosensitivity)[Ref]


Frequency not reported: Leukopenia and leukocytosis (usually transient)[Ref]


Frequency not reported: Elevated serum transaminase and elevated alkaline phosphatase (usually transient)[Ref]


Frequency not reported: Anorexia, increased appetite, increased weight, polydipsia[Ref]


Frequency not reported: Hyperpyrexia, weakness/fatigue, peripheral edema[Ref]


Frequency not reported: Dry mouth, constipation, increased salivation[Ref]


Frequency not reported: Blurred vision[Ref]


Frequency not reported: Increased sweating[Ref]


Frequency not reported: Nasal congestion[Ref]


1. "Product Information. Navane (thiothixene)." Roerig Division, New York, NY.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.