Ludiomil Side Effects

Generic name: maprotiline

Medically reviewed by Drugs.com. Last updated on Aug 8, 2023.

Note: This document contains side effect information about maprotiline. Some dosage forms listed on this page may not apply to the brand name Ludiomil.

Applies to maprotiline: oral tablet.

Warning

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;
blurred vision, eye pain or redness, seeing halos around lights;
confusion, hallucinations;
unusual thoughts or behavior;
memory problems;
fever, sore throat; or
jaundice (yellowing of the skin or eyes).

Common side effects may include:

blurred vision;
dry mouth;
nausea, constipation;
feeling nervous, anxious, or agitated;
sleep problems (insomnia);
dizziness, drowsiness;
feeling weak or tired;
headache; or
tremors.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to maprotiline: oral tablet.

General

The most commonly reported side effects include dry mouth, drowsiness, and dizziness.^[Ref]

Gastrointestinal

Very common (10% or more): Dry mouth (up to 22%)

Common (1% to 10%): Constipation, nausea

Rare (0.01% to 0.1%): Vomiting, epigastric distress, diarrhea, bitter taste, abdominal cramps, dysphagia, increased salivation

Frequency not reported: Sublingual adenitis, black tongue, stomatitis, paralytic ileus^[Ref]

Nervous system

Very common (10% or more): Drowsiness (up to 16%)

Common (1% to 10%): Dizziness, tremor, headache

Rare (0.01% to 0.1%): Decreased memory, numbness, tingling, motor hyperactivity, akathisia, EEG alterations, extrapyramidal symptoms, ataxia, dysarthria

Frequency not reported: Stroke, peripheral neuropathy^[Ref]

Psychiatric

Common (1% to 10%): Nervousness, anxiety, insomnia, agitation

Rare (0.01% to 0.1%): Confusional states, hallucinations, disorientation, delusions, restlessness, nightmares, hypomania, mania, psychosis exacerbation, feelings of unreality, decreased libido^[Ref]

Other

Common (1% to 10%): Weakness, fatigue

Rare (0.01% to 0.1%): Tinnitus, drug fever^[Ref]

Ocular

Common (1% to 10%): Blurred vision

Rare (0.01% to 0.1%): Accommodation disorder, mydriasis^[Ref]

Cardiovascular

Rare (0.01% to 0.1%): Hypotension, hypertension, tachycardia, palpitation, arrhythmia, heart block, syncope, edema

Frequency not reported: Myocardial infarction^[Ref]

Dermatologic

Rare (0.01% to 0.1%): Skin rash, petechia, itching, photosensitization, excessive perspiration, flushing, alopecia

Postmarketing reports: Stevens-Johnson syndrome, toxic epidermal necrolysis^[Ref]

Genitourinary

Rare (0.01% to 0.1%): Urinary retention, delayed micturition, impotence, urinary frequency

Frequency not reported: Breast enlargement (in women), galactorrhea, testicular swelling^[Ref]

Hepatic

Rare (0.01% to 0.1%): Altered liver function, jaundice

Postmarketing reports: Increased liver enzymes^[Ref]

Metabolic

Rare (0.01% to 0.1%): Elevation/depression of blood sugar levels, weight loss or gain^[Ref]

Respiratory

Rare (0.01% to 0.1%): Nasal congestion

Postmarketing reports: Interstitial pneumonitis^[Ref]

Interstitial pneumonitis was occasionally associated with eosinophilia and increased liver enzymes. However, no clear causal relationship to treatment has been established.^[Ref]