Kombiglyze XR Side Effects

Generic Name: metformin / saxagliptin

Note: This page contains side effects data for the generic drug metformin / saxagliptin. It is possible that some of the dosage forms included below may not apply to the brand name Kombiglyze XR.

It is possible that some side effects of Kombiglyze XR may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to metformin / saxagliptin: oral tablet extended release

As well as its needed effects, metformin / saxagliptin may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking metformin / saxagliptin, check with your doctor immediately:

More common
  • Anxiety
  • bladder pain
  • bloody or cloudy urine
  • blurred vision
  • body aches or pain
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • cough
  • depression
  • difficult, burning, or painful urination
  • difficulty with breathing
  • dizziness
  • ear congestion
  • fast heartbeat
  • fever
  • frequent urge to urinate
  • headache
  • increased hunger
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • nausea
  • nervousness
  • nightmares
  • runny nose
  • seizures
  • shakiness
  • slurred speech
  • sneezing
  • sore throat
  • unusual tiredness or weakness
  • Cough or hoarseness
Incidence not known
  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • constipation
  • darkened urine
  • difficulty with swallowing
  • hives
  • indigestion
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • tightness in the chest
  • unusual bleeding or bruising
  • vomiting
  • wheezing
  • yellow eyes or skin

Some metformin / saxagliptin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Diarrhea
  • muscle aches
  • stuffy nose
Less common
  • Abdominal or stomach pain
  • itching
  • pain or tenderness around the eyes and cheekbones
  • redness of the skin
  • weakness
  • welts

For Healthcare Professionals

Applies to metformin / saxagliptin: oral tablet extended release


Gastrointestinal side effects have included diarrhea, nausea, vomiting, abdominal pain, and gastroenteritis.


Metabolic side effects have included hypoglycemia.

Nervous system

Nervous system side effects have included headache.


Hypersensitivity side effects have included urticaria and facial edema.


Respiratory side effects have included sinusitis, nasopharyngitis and upper respiratory tract infection.


Musculoskeletal side effects have included fractures.


Hematologic side effects have included thrombocytopenia and lymphopenia.


Dermatologic side effects have included rash.


General side effects have included infections, including tuberculosis.


Genitourinary side effects have included urinary tract infection.

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