Intuniv Side Effects

Generic Name: guanfacine

Note: This page contains information about the side effects of guanfacine. Some of the dosage forms included on this document may not apply to the brand name Intuniv.

Not all side effects for Intuniv may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to guanfacine: oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by guanfacine (the active ingredient contained in Intuniv). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking guanfacine:

More common
  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness
Less common
  • Chest pain or discomfort
  • cough
  • difficulty with breathing
  • fast, slow, or irregular heartbeat
  • increased need to urinate
  • lightheadedness, dizziness, or fainting
  • mental depression
  • noisy breathing
  • passing urine more often
  • pounding heartbeat
  • tightness in the chest

If any of the following symptoms of overdose occur while taking guanfacine, get emergency help immediately:

Symptoms of overdose
  • Dizziness (extreme) or faintness
  • unusual tiredness or weakness (severe)

Some of the side effects that can occur with guanfacine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Constipation
  • dizziness
  • drowsiness
  • dryness of the mouth
  • headache
  • irritability
  • nausea
  • sleepiness or unusual drowsiness
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  • upper abdominal or stomach pain
  • vomiting
  • weight gain
Less common
  • Acid or sour stomach
  • belching
  • decreased appetite
  • decreased sexual ability
  • dry, itching, or burning eyes
  • heartburn
  • indigestion
  • lack or loss of strength
  • paleness of the skin
  • stomach discomfort, upset, or pain
  • trouble with sleeping

After you stop taking this drug, it is possible that you may still experience side effects that need medical attention. If you notice any of the following side effects check with your doctor immediately:

  • Anxiety or tenseness
  • increased salivation
  • nervousness or restlessness
  • shaking or trembling of the hands and fingers
  • stomach cramps
  • sweating

For Healthcare Professionals

Applies to guanfacine: oral tablet, oral tablet extended release

General

Guanfacine (the active ingredient contained in Intuniv) is generally well-tolerated. In a study of 580 hypertensive patients, only 7% withdrew due to adverse side effects. In addition, most side effects were mild, dose-related, and resolved over time.

Nervous system

Nervous system side effects have included fatigue or a sedative effect and dizziness in 33% and 15% of patients, respectively. After one year of therapy, the incidence of these side effects falls to 6% and 1%, respectively. Headaches occur in less than 5% of patients. Nervous system side effects associated with the extended-release formulation have included somnolence (38%), fatigue (14%), headache (24%), lethargy (6%), dizziness (6%), and postural dizziness (less than 2%).

Gastrointestinal

Gastrointestinal side effects have included dry mouth in up to 60% of patients. Constipation has been associated with the use of this drug in 14% of patients. After one year of therapy the incidence of dry mouth and constipation averages 15% and 3%, respectively. Gastrointestinal side effects associated with the extended-release formulation have included dry mouth (4%), upper abdominal pain (10%), nausea (6%), and dyspepsia (less than 2%).

Cardiovascular

Cardiovascular side effects have included orthostatic hypotension and palpitations, each of which is rare. There is limited, indirect (ECG) evidence of left ventricular hypertrophy resolution after guanfacine (the active ingredient contained in Intuniv) therapy. Cardiovascular side effects associated with the extended-release formulation have included hypotension/decreased blood pressure (6%), atrioventricular block (less than 2%), bradycardia (less than 2%), and sinus arrhythmia (less than 2%) .

Genitourinary

Genitourinary complaints in male patients are limited to impotence, which is associated with higher doses (daily doses of 3 mg or more).

Metabolic

Metabolic side effects associated with the extended-release formulation have included decreased appetite (5%), and constipation (3%).

Psychiatric

Psychiatric side effects associated with the extended-release formulation have included irritability (6%)

Postmarketing reports: Hallucinations

Respiratory

Respiratory side effects associated with the extended-release formulation have included asthma (less than 2%).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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