Guanfacine Pregnancy and Breast Feeding Warnings

Guanfacine is also known as: Tenex

Overview

If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Guanfacine while you are pregnant. It is not known if Guanfacine is found in breast milk. If you are or will be breast-feeding while you use Guanfacine , check with your doctor. Discuss any possible risks to your baby.

Guanfacine Pregnancy Warnings

Guanfacine has been assigned to pregnancy category B by the FDA. Animal studies have revealed evidence of maternal toxicity and decreased fetal survival after doses 100 and 200 times the maximum recommended human dose (on a per kg basis) were given to rabbits and rats, respectively. Doses less than these were not associated with any evidence of harm to the fetus. There are no controlled data in human pregnancy. Guanfacine should only be given during pregnancy when need has been clearly established.

Guanfacine effectively reduced blood pressure in 30 pregnant women with preeclampsia, but edema and proteinuria persisted. There were no notable changes in either the fetal or maternal heart rate. Of the 30 neonates, six were considered "small for date babies", but this was expected given the underlying diseases of the mothers. No congenital anomalies were observed among the offspring, and all developed normally.

Guanfacine Lactation Warnings

There are no data on the excretion of guanfacine into human milk.

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