Guanfacine Pregnancy and Breastfeeding Warnings
Guanfacine Pregnancy Warnings
Guanfacine effectively reduced blood pressure in 30 pregnant women with preeclampsia, but edema and proteinuria persisted. There were no notable changes in either the fetal or maternal heart rate. Of the 30 neonates, six were considered "small for date babies", but this was expected given the underlying diseases of the mothers. No congenital anomalies were observed among the offspring, and all developed normally.
Guanfacine has been assigned to pregnancy category B by the FDA. Animal studies have revealed evidence of maternal toxicity and decreased fetal survival after doses 100 and 200 times the maximum recommended human dose (on a per kg basis) were given to rabbits and rats, respectively. Doses less than these were not associated with any evidence of harm to the fetus. There are no controlled data in human pregnancy. Guanfacine should only be given during pregnancy when need has been clearly established.
Guanfacine Breastfeeding Warnings
There are no data on the excretion of guanfacine into human milk. Studies have shown that guanfacine is excreted into the milk of lactating rats. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
- Guanfacine use while Breastfeeding (in more detail)
- guanfacine Consumer Information
- Pregnancy Support Group
- FDA Pregnancy Categories
- Medicine use during Pregnancy
- Medicine use while Breastfeeding
- Safe Medications during Breastfeeding
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This drug information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.