IncobotulinumtoxinA Side Effects

Not all side effects for incobotulinumtoxinA may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to incobotulinumtoxinA: intramuscular powder for solution

In addition to its needed effects, some unwanted effects may be caused by incobotulinumtoxinA. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking incobotulinumtoxinA, check with your doctor or nurse immediately:

More common—for cervical dystonia
  • Difficulty with swallowing
  • muscle or bone pain
  • muscle weakness
  • pain in the neck
More common—for blepharospasm
  • Dry eyes
Rare—for glabellar lines
  • Itching, pain, redness, or swelling at the injection site
  • pain in the face
  • swelling of the eyelids
Incidence not known
  • Changes in patterns and rhythms of speech
  • fast heartbeat
  • fever
  • hives
  • hoarseness
  • irritation
  • itching
  • joint pain, stiffness, or swelling
  • muscle spasm
  • pain at the injection site
  • rash
  • redness of the skin
  • shortness of breath
  • slurred speech
  • swelling of the eyes or eyelids
  • swelling of the face, lips, hands, or feet
  • tightness in the chest
  • trouble with speaking
  • troubled breathing or swallowing
  • wheezing

Some of the side effects that can occur with incobotulinumtoxinA may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common—for cervical dystonia
  • Chills
  • cough
  • lower back or side pain
  • painful or difficult urination
More common—for blepharospasm
  • Blurred vision
  • diarrhea
  • drooping upper eyelids
  • dry mouth
  • headache
Less common—for blepharospasm
  • Difficult or labored breathing
  • muscle aches
  • sneezing
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness
Rare—for glabellar lines
  • Drooping of the eyelids
  • increased blinking
  • twitching of the eyelids
Incidence not known
  • Difficulty with moving
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • nausea
  • painful blisters on the trunk of the body
  • swollen joints

For Healthcare Professionals

Applies to incobotulinumtoxinA: intramuscular powder for injection

Musculoskeletal

Musculoskeletal side effects have included neck pain (7% to 15%), muscular weakness (7% to 11%), musculoskeletal pain (4% to 7%), and muscle spasm.

Gastrointestinal

Gastrointestinal side effects have included dysphagia (13%), dry mouth (16%), diarrhea (8%), and nausea.

Nervous system

Nervous system side effects have included headache (7%).

Local

Local side effects have included injection site pain (9%), injection site reaction, allergic dermatitis, localized allergic reactions like swelling, edema, erythema, pruritus or rash, and herpes zoster.

Ocular

Ocular side effects have included eyelid ptosis (19%), dry eye (16%), visual impairment (12%), eye swelling, and eyelid edema.

Respiratory

Respiratory side effects have included nasopharyngitis (5%), respiratory tract infection (5%), and dyspnea (5%).

Immunologic

Immunologic side effects have included infections and infestations (13% to 14%). Postmarketing reports have included flu-like symptoms.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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