Halaven Side Effects

Generic Name: eribulin

Note: This page contains information about the side effects of eribulin. Some of the dosage forms included on this document may not apply to the brand name Halaven.

Not all side effects for Halaven may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to eribulin: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by eribulin (the active ingredient contained in Halaven). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking eribulin, check with your doctor or nurse immediately:

More common
  • Black, tarry stools
  • bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • body aches or pain
  • burning, numbness, tingling, or painful sensations
  • chills
  • convulsions
  • cough
  • decreased urine
  • decreased weight
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • dry mouth
  • ear congestion
  • fever
  • frequent urge to urinate
  • headache
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nasal congestion
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • pale skin
  • rapid weight gain
  • runny nose
  • shortness of breath
  • sneezing
  • sore throat
  • tightness in the chest
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • weakness in the arms, hands, legs, or feet
  • wheezing
Incidence not known
  • Fainting
  • irregular heartbeat, recurrent

Some of the side effects that can occur with eribulin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Acid or sour stomach
  • back pain
  • belching
  • bone pain
  • change in taste
  • cracked lips
  • depression
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • difficulty with swallowing
  • dizziness
  • hair loss or thinning of the hair
  • heartburn
  • indigestion
  • lack or loss of strength
  • loss of taste
  • muscle spasm or weakness
  • muscle stiffness
  • pain in the arms or legs
  • pain in the joints
  • rash
  • sleeplessness
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • stomach discomfort, upset, or pain
  • swelling or inflammation of the mouth
  • trouble sleeping
  • unable to sleep
  • watering of the eyes
  • weight loss

For Healthcare Professionals

Applies to eribulin: intravenous solution

Hematologic

Hematologic side effects have included neutropenia (82%), anemia (58%), febrile neutropenia, and thrombocytopenia.[Ref]

In one study, grade 3 neutropenia occurred in 28% of patients, 29% experience grade 4 neutropenia, and 5% of patients experienced febrile neutropenia. Dose reductions due to neutropenia occurred in 12% of patients and discontinuation was required in less than 1% of patients. Grade 3 or greater thrombocytopenia was reported in 1% of patients. Granulocyte colony-stimulating factor or granulocyte-macrophage colony-stimulating factor was used in 19% of patients treated with eribulin.[Ref]

Nervous system

Nervous system side effects have included peripheral neuropathy (35%), headache (19%), peripheral motor neuropathy, polyneuropathy, peripheral sensory neuropathy, paraesthesia, dysgeusia, and dizziness.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea (35%), constipation (25%), anorexia (20%), diarrhea (18%), vomiting (18%), mucosal inflammation (9%), dyspepsia, abdominal pain, stomatitis, and dry mouth. Postmarketing gastrointestinal side effects have included reports of pancreatitis.[Ref]

Cardiovascular

Cardiovascular side effects have included QT interval prolongation and peripheral edema.[Ref]

Dermatologic

Dermatologic side effects have included alopecia (45%) and rash.[Ref]

Genitourinary

Genitourinary side effects have included urinary tract infection (10%).[Ref]

Hepatic

Hepatic side effects have included increased liver enzymes and increased bilirubin.[Ref]

Metabolic

Metabolic side effects have included weight loss (21%) and hypokalemia.[Ref]

Musculoskeletal

Musculoskeletal side effects have included arthralgia (22%), myalgia (22%), back pain (16%), bone pain (12%), pain in extremity (11%), muscle spasms, and muscular weakness.[Ref]

Ocular

Ocular side effects have included increased lacrimation.[Ref]

Other

Other side effects have included asthenia (54%), fatigue (54%) and pyrexia (21%).[Ref]

Psychiatric

Psychiatric side effects have included insomnia and depression.[Ref]

Respiratory

Respiratory side effects have included dyspnea (16%), cough (14%), and upper respiratory tract infection.[Ref]

References

1. "Product Information. Halaven (eribulin)." Eisai Inc, Teaneck, NJ.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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