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Dorzolamide ophthalmic Side Effects

Not all side effects for dorzolamide ophthalmic may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to dorzolamide ophthalmic: ophthalmic solution

In addition to its needed effects, some unwanted effects may be caused by dorzolamide ophthalmic. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking dorzolamide ophthalmic:

More common
  • Burning, stinging, or discomfort when medicine is applied
  • itching, redness, swelling, or other sign of the eye or eyelid irritation
Less common
  • Burning, dry, or itching eyes
  • discharge from the eye
  • excessive tearing
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • Blood in the urine
  • blurred vision
  • nausea or vomiting
  • pain in the side, back, or abdomen
  • skin rash
  • tearing
Incidence not known
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • change in vision
  • chills
  • cough
  • diarrhea
  • difficult or labored breathing
  • flashes of light
  • floaters in vision
  • hives or welts
  • itching skin
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • noisy breathing
  • redness of the skin
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • tightness in the chest
  • unusual tiredness or weakness

If any of the following symptoms of overdose occur while taking dorzolamide ophthalmic, get emergency help immediately:

Symptoms of overdose
  • Confusion
  • irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • seizures
  • trembling
  • weakness and heaviness of the legs

Some of the side effects that can occur with dorzolamide ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Bitter taste
  • feeling of something in the eye
Less common
  • Changes in color vision
  • difficulty seeing at night
  • dryness of the eyes
  • eyelid reactions
  • headache
  • increased sensitivity of the eyes to sunlight
Incidence not known
  • Bloody nose
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in distance vision
  • difficulty in focusing the eyes
  • dizziness
  • dry mouth
  • eyelid crusting
  • lack or loss of strength
  • scaling of the skin
  • severe redness, soreness, or swelling of the skin

For Healthcare Professionals

Applies to dorzolamide ophthalmic: ophthalmic solution


Frequency not reported: Rash, Stevens-Johnson syndrome, toxic epidermal necrolysis
Postmarketing reports: Contact dermatitis[Ref]


Very common (10% or more): Bitter test (25%)
Uncommon (0.1% to 1%): Nausea, throat irritation, dry mouth
Postmarketing reports: Dry mouth, throat irritation[Ref]


Most frequent: Ocular burning, stinging, discomfort immediately following ocular administration (approximately in one-third of patients)[Ref]


Rare (less than 0.1%): Urolithiasis[Ref]


Postmarketing reports: Epistaxis[Ref]


Very common (10% or more): Angioedema, pruritus, urticaria, bronchospasm, skin rashes, contact dermatitis
Postmarketing reports: Dyspnea[Ref]

Nervous system

Frequency not reported: Headache, asthenia, paresthesia and dizziness[Ref]


Very common (10% or more): Burning and stinging (approximately in 33%), superficial punctate epithelial erosions in 10% to 15% of the patients
Common (1% to 10%): Conjunctivitis, lid reactions, dryness, eye redness, photophobia, tearing, and blurred vision in 1% to 5% of the patients
Rare (less than 0.1%): Iridocyclitis
Frequency not reported: Slight increases in central corneal thickness have been reported in patients with cornea guttata after short-term (1 day) use of dorzolamide. A single case of abrupt choroidal detachment in a surgically untreated eye has been reported.
Postmarketing reports: Ocular pain, transient myopia, eyelid crusting, choroidal detachment following filtration surgery[Ref]

Foreign body sensation has been reported due to formation of precipitate on the tip of the dropper bottle, which entered the eye during instillation of the eye drops.[Ref]


1. "Product Information. Trusopt (dorzolamide ophthalmic)." Merck & Co, Inc, West Point, PA.

2. Strahlman E, Tipping R, Vogel R "A double-masked, randomized 1-year study comparing dorzolamide (trusopt), timolol, and betaxolol." Arch Ophthalmol 113 (1995): 1009-16

3. Goldberg S, Gallily R, Bishara S, Blumenthal EZ "Dorzolamide-induced choroidal detachment in a surgically untreated eye." Am J Ophthalmol 138 (2004): 285-6

4. Zambarakji HJ, Spencer AF, Vernon SA "An unusual side effect of Dorzolamide." Eye 11(Pt 3) (1997): 418-9

5. Epstein RJ, Brown SV, Konowal A "Endothelial changes associated with topical dorzolamide do appear to be significant." Arch Ophthalmol 122 (2004): 1089; author reply 1090

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