Depo-Provera Side Effects
Generic Name: Medroxyprogesterone
Please note - some side effects for Depo-Provera may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).
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For the consumer For the professional
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Side Effects of Depo-Provera - for the consumer
Depo-Provera Injectable Suspension
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Depo-Provera Injectable Suspension:
Seek medical attention right away if any of these SEVERE side effects occur when using Depo-Provera Injectable Suspension:Acne; dizziness; drowsiness; fever; headache; hot flashes; nausea; nervousness; pain, redness, and swelling at injection site; sleeplessness; weakness.
TopSevere allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood clots; changes in menstrual flow, including breakthrough bleeding, spotting, or missed periods; chest pain; mental or mood changes; partial or complete loss of vision or changes in vision; severe dizziness or fainting; severe stomach pain; shortness of breath; slurred speech; sudden loss of coordination; sudden or severe headache or vomiting; swelling of fingers or ankles; unusual weight gain or loss; weakness, numbness, or pain in the arms or legs; yellowing of the skin or eyes.
For the professional
Depo-Provera
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–breakthrough bleeding
–spotting
–change in menstrual flow
–amenorrhea
–headache
–nervousness
–dizziness
–edema
–change in weight (increase or decrease)
–changes in cervical erosion and cervical secretions
–cholestatic jaundice, including neonatal jaundice
–breast tenderness and galactorrhea
–skin sensitivity reactions consisting of urticaria, pruritus, edema and generalized rash
–acne, alopecia and hirsutism
–rash (allergic) with and without pruritis
–anaphylactoid reactions and anaphylaxis
–mental depression
–pyrexia
–fatigue
–insomnia
–nausea
–somnolence
In a few instances there have been undesirable sequelae at the site of injection, such as residual lump, change in color of skin, or sterile abscess.
A statistically significant association has been demonstrated between use of estrogen-progestin combination drugs and pulmonary embolism and cerebral thrombosis and embolism. For this reason patients on progestin therapy should be carefully observed. There is also evidence suggestive of an association with neuro-ocular lesions, e.g. retinal thrombosis and optic neuritis.
The following adverse reactions have been observed in patients receiving estrogen-progestin combination drugs:
–rise in blood pressure in susceptible individuals
–premenstrual syndrome
–changes in libido
–changes in appetite
–cystitis-like syndrome
–headache
–nervousness
–fatigue
–backache
–hirsutism
–loss of scalp hair
–erythema multiforma
–erythema nodosum
–hemorrhagic eruption
–itching
–dizziness
The following laboratory results may be altered by the use of estrogen-progestin combination drugs:
–increased sulfobromophthalein retention and other hepatic function tests
–coagulation tests: increase in prothrombin factors VII, VIII, IX, and X
–metyrapone test
–pregnanediol determinations
–thyroid function: increase in PBI, and butanol extractable protein bound iodine and decrease in T3 uptake values
More resources:
Depo-Provera Injectable Suspension
Depo-Provera - Includes detailed dosage instructions.
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