Dapsone topical Side Effects

Brand Names: Aczone

Please note - some side effects for Dapsone topical may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects by Body System

Local

Local side effects for dapsone topical in relation to the vehicle alone have frequently included dryness (16% vs. 17%), erythema (13% vs. 14%), burning (1% vs. 2%), and pruritus (1% vs. 1%) at the site of application.

Respiratory

Respiratory side effects for dapsone topical in relation to the vehicle alone have included nasopharyngitis (5% vs. 6%), upper respiratory tract infection (3% vs. 3%), sinusitis (2% vs. 1%), pharyngitis (2% vs. 2%), and cough (2% vs. 2%).

Other

Other side effects for dapsone topical in relation to the vehicle alone have included pyrexia (1% vs. 1%), influenza (1% vs. 1%), and headache (4% vs. 4%). Facial swelling (1 case) resulting in discontinuation of treatment has been reported.

Musculoskeletal

Musculoskeletal side effects for dapsone topical in relation to the vehicle alone have included joint sprain (1% vs. 1%).

Nervous system

Nervous system side effects have included tonic clonic movements.

Psychiatric

Clinical trials (n=2372) reported 9 and 2 patients treated with dapsone topical to have depression and psychosis, respectively.

Psychiatric side effects have included suicide attempt, depression, and psychosis.

Gastrointestinal

Gastrointestinal side effects have included abdominal pain, severe vomiting, and pancreatitis.

Hematologic

Hematologic side effects have included increased reticulocyte count and decreased hemoglobin level in a single patient with G6PD deficiency who had a complete blood count performed prior to initiation of treatment.

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