Dapsone use while Breastfeeding

Drugs containing Dapsone: Aczone

Dapsone Levels and Effects while Breastfeeding

Summary of Use during Lactation

Dapsone can be used during breastfeeding; however, hemolytic anemia might occur, especially in newborn infants and those with G-6-PD deficiency. One source states that use of dapsone in the treatment of leprosy is advantageous because it kills the organisms in breastmilk.[1] Monitor the infant for signs of hemolysis, especially in newborn or premature breastfed infants.

Drug Levels

Maternal Levels. In one mother who was 41 days postpartum, a random milk level of dapsone was about 1.1 mg/L with a maternal dose of 50 mg daily. Monoacetyldapsone was not detectable in milk although the maternal serum level was 744 mcg/L.[2]

Three women who were 2 to 5 days postpartum were given a single dose of 100 mg of dapsone orally. Milk samples were obtained at various times up to about 220 hours after the dose. The authors calculated that the breastfed infants would receive an average of 9.6% (range 4.6 to 14.3%) of the maternal weight-adjusted dosage.[3]

Infant Levels. A mother who was 41 days postpartum was taking dapsone 50 mg daily. Her breastfed infant's serum had levels of 439 mcg/L of dapsone and 204 mcg/L of monoacetyldapsone.[2]

Effects in Breastfed Infants

A case of mild hemolytic anemia occurred in a 41-day-old breastfed infant whose mother was taking dapsone 50 mg daily. The hemolysis was probably caused by dapsone in milk.[2]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Clofazimine

References

1. Jopling WH. Handbook of leprosy. 3rd Ed. London: Heinemann Medical Books Ltd. 1984: 86-7.

2. Sanders SW, Zone JJ, Foltz RL et al. Hemolytic anemia induced by dapsone transmitted through breast milk. Ann Intern Med. 1982;96:465-6. PMID: 7065565

3. Edstein MD, Veenendaal JR, Newman K, Hyslop R. Excretion of chloroquine, dapsone and pyrimethamine in human milk. Br J Clin Pharmacol. 1986;22:733-5. PMID: 3567020

Dapsone Identification

Substance Name

Dapsone

CAS Registry Number

80-08-0

Drug Class

Antiinfective Agents

Leprostatic Agents

Administrative Information

LactMed Record Number

695

Last Revision Date

20130907

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