Clobazam Side Effects

Not all side effects for clobazam may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to clobazam: oral suspension, oral tablet

In addition to its needed effects, some unwanted effects may be caused by clobazam. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking clobazam:

More common
  • Difficulty with swallowing
  • fever
  • shakiness and unsteady walk
  • unsteadiness, trembling, or other problems with muscle control or coordination
Less common
  • Change in speech pattern
  • restlessness
  • slurred speech
  • trouble sitting still
  • trouble speaking
Incidence not known
  • Agitation
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • blood in the urine or stools
  • chest pain
  • chills
  • confusion as to time, place, or person
  • cough
  • diarrhea
  • difficult or troubled breathing
  • holding false beliefs that cannot be changed by fact
  • irregular, fast or slow, or shallow breathing
  • itching
  • joint or muscle pain
  • lack of feeling or emotion
  • painful or difficult urination
  • pale or blue lips, fingernails, or skin
  • pinpoint red spots on the skin
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seeing, hearing, or feeling things that are not there
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • swollen glands
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness

Some of the side effects that can occur with clobazam may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Aggressive
  • body aches or pain
  • decreased appetite
  • difficulty having a bowel movement (stool)
  • drooling
  • ear congestion
  • irritability
  • loss of voice
  • nasal congestion
  • runny nose
  • sleepiness or unusual drowsiness
  • sneezing
  • vomiting
Less common
  • Bladder pain
  • cloudy urine
  • cough with mucus
  • frequent urge to urinate
  • increased appetite
  • lower back or side pain
Incidence not known
  • Double vision
  • full or bloated feeling
  • headache
  • muscle spasms
  • pressure in the stomach
  • rash, hives, or welts
  • red skin
  • swelling of the stomach area

For Healthcare Professionals

Applies to clobazam: oral suspension, oral tablet

Dermatologic

Dermatologic side effects reported postmarketing have included rash, Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and urticaria.[Ref]

Gastrointestinal

Gastrointestinal side effects have included vomiting (7%) and constipation (5%). Gastrointestinal side effects reported postmarketing have included abdominal distention.[Ref]

General

General side effects have included dysphagia (2%).[Ref]

Genitourinary

Genitourinary side effects have included urinary tract infection (4%).[Ref]

Hematologic

Hematologic side effects reported postmarketing have included anemia, eosinophilia, leukopenia, and thrombocytopenia.[Ref]

Metabolic

Metabolic side effects have included decreased appetite (3%) and increased appetite (3%).[Ref]

Nervous system

Nervous system side effects have included pyrexia (13%), irritability (7%), fatigue (5%), somnolence (22%), sedation (5%), lethargy (10%), drooling (9%), ataxia (5%), psychomotor hyperactivity (4%), and dysarthria (3%).[Ref]

Ocular

Ocular side effects reported postmarketing have included diplopia and blurred vision.[Ref]

Psychiatric

Psychiatric side effects have included aggression (8%) and insomnia (5%). Psychiatric side effects reported postmarketing have included agitation, anxiety, apathy, confused state, depression, delirium, delusion, and hallucination.[Ref]

Respiratory

Respiratory side effects have included upper respiratory tract infection (4%), pneumonia (4%), bronchitis (2%), and cough (5%). Respiratory side effects reported postmarketing have included aspiration and respiratory depression.[Ref]

References

1. "Product Information. Onfi (clobazam)." Lundbeck Inc, Deerfield, IL.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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