Amiodarone Side Effects

Not all side effects for amiodarone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to amiodarone: oral tablet

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by amiodarone. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking amiodarone:

More common
  • Cough
  • dizziness, lightheadedness, or fainting
  • fever (slight)
  • numbness or tingling in the fingers or toes
  • painful breathing
  • sensitivity of the skin to sunlight
  • shortness of breath
  • trembling or shaking of the hands
  • trouble with walking
  • unusual and uncontrolled movements of the body
  • weakness of the arms or legs
Less common
  • Blue-gray coloring of the skin on the face, neck, and arms
  • blurred vision or blue-green halos seen around objects
  • coldness
  • dry eyes
  • dry, puffy skin
  • fast or irregular heartbeat
  • nervousness
  • pain and swelling in the scrotum
  • sensitivity of the eyes to light
  • sensitivity to heat
  • slow heartbeat
  • sweating
  • swelling of the feet or lower legs
  • trouble with sleeping
  • unusual tiredness
  • weight gain or loss
Rare
  • Skin rash
  • yellow eyes or skin
Incidence not known
  • Abdominal or stomach pain
  • agitation
  • back, leg, or stomach pains
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • bloating
  • blood in the urine
  • bloody, black, or tarry stools
  • blue lips, fingernails, or skin
  • blurred or double vision
  • chest pain
  • chills
  • clay-colored stools
  • coma
  • confusion
  • confusion as to time, place, or person
  • coughing or spitting up blood
  • cracks in the skin
  • dark urine
  • decreased urine output
  • depression
  • diarrhea
  • difficult or labored breathing
  • difficult urination
  • dry cough
  • eye pain
  • fast heartbeat
  • fatigue
  • general body swelling
  • high fever
  • holding false beliefs that cannot be change by fact
  • hostility
  • inability to have or keep an erection
  • indigestion
  • irregular, fast or slow, or shallow breathing
  • irritability
  • itching
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lethargy
  • loss in sexual ability, desire, drive, or performance
  • loss of heat from the body
  • lower back or side pain
  • mood or mental change
  • muscle cramps or spasms
  • muscle pain or stiffness
  • muscle twitching
  • no breathing
  • noisy breathing
  • nosebleeds
  • pain in the abdomen, groin, or scrotum
  • pain or burning with urination
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • scaly skin
  • seeing, hearing, or feeling things that are not there
  • seizures
  • severe headache
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on the lips or in mouth
  • stupor
  • swelling of the face, ankles, or hands
  • swelling of the scrotum
  • swollen or painful glands
  • tightness in the chest
  • troubled breathing
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness
  • vomiting of blood
  • wheezing

Some of the side effects that can occur with amiodarone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Constipation
  • headache
  • loss of appetite
  • nausea and vomiting
Less common
  • Bitter or metallic taste
  • decrease in sexual interest
  • decreased sexual ability in males
  • dizziness
  • flushing of the face

For Healthcare Professionals

Applies to amiodarone: compounding powder, intravenous solution, oral tablet

Ocular

Ocular side effects have been reported the most frequently and have included corneal microdeposits (up to 98%) which only rarely caused visual halos or blurred vision, corneal opacities, lenticular changes, loss of eyelashes or eyebrows, papilledema, photosensitivity, scotoma, macular degeneration, and optic neuropathy or optic neuritis.[Ref]

Amiodarone-induced ocular side effects are time- and dose-dependent. The most commonly affected ocular structure is the cornea with punctuate opacities occurring in 69% to 100% of patients. Lenticular changes may include anterior, subcapsular, small, yellow-white punctuate opacities.

The incidence of optic neuropathy, the most severe ocular side effect of amiodarone, ranges from 0.36% to 2%. Amiodarone-related optic neuropathy has been characterized as having an insidious onset, slow progression, bilateral vision loss, and protracted disc edema. In one report which was based on 50 cases, the median duration of treatment until onset of vision loss was 4 months. In one case, vision loss occurred after 24 months of treatment. It should be noted that because of similar clinical features, amiodarone-induced optic neuropathy can be confused with idiopathic nonarteritic anterior ischemic optic neuropathy.[Ref]

Cardiovascular

Cardiovascular side effects have included hypotension (10% to 30%), bradycardia (1% to 10%), worsening heart failure (1% to 5%), asystole/cardiac arrest/electromechanical dissociation (3.5%), cardiogenic shock (3%), congestive heart failure (2.2%), ventricular tachycardia (1.8%), second- and third-degree AV nodal block (less than 2%), AV heart block (1%), and Torsades de pointes (0.7%). Rarely, cases of ventricular fibrillation have been reported. Hypotension, vasculitis, and sinus arrest have been reported in postmarketing experience. One- year sudden death has been reported. A case of endocarditis and pleuropericardial effusion has been reported.[Ref]

Limited data have shown that the incidence of one-year sudden death was markedly and significantly increased in patients with advanced heart failure and a history of torsades de pointes taking amiodarone compared with such patients who were not taking amiodarone.

The results of a meta-analysis indicate that use of amiodarone for the prevention of postoperative atrial fibrillation increases the risk of developing bradycardia and hypotension. However, other meta- analyses have shown that the use of amiodarone in the same setting reduced the rate of postoperative atrial fibrillation and stroke.[Ref]

Respiratory

Amiodarone-induced pulmonary toxicity (AIPT) occurs with an incidence of 1% to 17%, typically manifests as acute pneumonitis and chronic fibrosis, and can be life threatening. In general, AIPT develops in 0.1% to 0.5% of patients that take up to 200 mg daily and 5% to 15% of patients that take 500 mg or more daily. AIPT has proven fatal in approximately 5% to 10% of cases when patients were on dosages of more than 400 mg daily; however, in patients who develop acute respiratory failure due to AIPT and require ventilation, mortality is 50% to 100%. AIPT may occur early in therapy or after several years of treatment. Patients with preexisting pulmonary disease are at an increased risk of developing AIPT. The proposed mechanism of lung damage is the accumulation of phospholipids in the lungs. AIPT is reversible if diagnosed early. The more common form of AIPT is associated with doses of 400 mg daily or more, it has an insidious onset, typically manifests after 2 or more months of therapy and is characterized by a progressive nonproductive cough, dyspnea, weight loss, and possibly fever.[Ref]

Respiratory side effects including chronic pulmonary fibrosis have been reported in 1% to 7% of patients. Bronchial asthma has also been reported. Rarely, acute respiratory failure and pneumonitis have been reported. Pulmonary infiltrates, alveolar hemorrhage, bronchospasm, wheezing, fever, dyspnea, cough, hemoptysis, hypoxia, pleuritis, possibly fatal respiratory distress, respiratory failure, respiratory arrest, acute respiratory distress syndrome, and bronchiolitis obliterans organizing pneumonia have been reported in postmarketing experience. There have been additional postmarketing reports of eosinophilic pneumonia, pleural effusion, and acute respiratory distress syndrome in the postoperative setting.[Ref]

Endocrine

A 67-year-old male with SIADH developed hyponatremia. Although common comorbid conditions associated with SIADH were excluded as possible causes, his drug regimen and medical history were extensive. However, he had been taking spironolactone, amiodarone, and simvastatin for less than 3 months. The patient's serum sodium level began to rise within 3 days of discontinuation of amiodarone and returned to normal within 1 month.

Amiodarone-induced hypothyroidism occurs more frequently in iodine- sufficient regions than in iodine-deficient regions. It also occurs more frequently in female and elderly patients than in male or younger patients. Clinical manifestations of amiodarone- induced hypothyroidism may include fatigue, lethargy, bradycardia, dyspnea, cold intolerance, dry skin, weight gain, constipation, and reduced appetite.

Amiodarone-induced thyrotoxicosis (AIT) occurs more frequently in iodine-deficient regions and it primarily occurs in men (male to female ratio 3:1). AIT may develop in patients with or without preexisting thyroid dysfunction and at anytime during therapy including following discontinuation of treatment. In patients with AIT, laboratory results will reveal marked increases in the serum levels of thyroxine (T4) and possibly triiodothyronine (T3). When AIT occurs in patients with preexisting thyroid dysfunction (e.g., goiter, Grave's disease) it is referred to as AIT type I. When AIT occurs in patients without preexisting thyroid dysfunction it is referred to as AIT type II. AIT type II may be related to destructive inflammatory thyroiditis, caused by the cytotoxic effects of amiodarone and its metabolites on thyroid cells, which results in glandular damage and subsequent leakage of preformed thyroid hormones. Clinical manifestations of AIT may include palpitations, supraventricular tachycardia, weight loss, sweating, muscle weakness, tremor, insomnia, and mood swings. In type I AIT, serum levels of interleukin-6 are normal or slightly elevated, 24-hour uptake of radioactive iodine by the thyroid gland is normal to high, and there is an increase in vascularity. In type II AIT, serum levels of interleukin-6 are markedly increased, 24-hour uptake of radioactive iodine by the thyroid gland is low to none, and vascularity is normal. It should be noted that a patient may also have a mixture of type I and II AIT where the different features of the two types may coexist.[Ref]

Endocrine side effects have included thyroid abnormalities (30%), hyper- and hypothyroidism (5% to 10%), and thyrotoxicosis. Rare cases of thyroiditis have been reported. Syndrome of inappropriate antidiuretic hormone secretion (SIADH), thyroid nodules, and thyroid cancer have been reported in postmarketing experience.[Ref]

Gastrointestinal

Gastrointestinal side effects including anorexia have been reported in 2% to 20% of patients. Nausea, vomiting, constipation, and altered taste have been reported.[Ref]

Hypersensitivity

Hypersensitivity side effects including photosensitivity have been reported in 70% of patients. Toxic epidermal necrolysis and exfoliative dermatitis have been reported rarely. Anaphylactic/anaphylactoid reaction (including shock), angioedema, Stevens-Johnson syndrome, and erythema multiforme have been reported in postmarketing experience. A case of drug-induced lupus erythematosus has been reported. Postmarketing reports have included drug rash with eosinophilia and systemic symptoms.

A hypersensitivity (possible cross reactivity) reaction (i.e., lip swelling and tingling) to oral amiodarone has been described in a patient with a previous history of hypersensitivity to an iodinated radiocontrast agent.[Ref]

Immunologic

Immunologic side effects have been reported rarely. These have included polyserositis and cutaneous leukocytoclastic vasculitis.[Ref]

Hepatic

Hepatic side effects including symptomatic elevations in liver function tests have been reported in 50% of patients. Rarely, fatal cases of cirrhosis have been reported. A single case of hepatitis with pancreatitis has been reported. Jaundice has been reported. Hepatitis, cholestatic hepatitis, pancreatitis, and cirrhosis have been reported in postmarketing experience.[Ref]

In one case report, a patient developed hepatic cirrhosis associated with microvesicular steatosis after 22.5 months of low-dose (200 mg daily) oral amiodarone therapy.

According to the results of a retrospective study (n=720), the prevalence of significant liver dysfunction in patients taking oral amiodarone with or without elevated baseline alanine aminotransferase (ALT) is similar. The authors suggest that amiodarone may be safety administered to patients with elevated baseline ALT, but recommend close monitoring of liver function.[Ref]

Dermatologic

Dermatologic side effects have included photosensitivity (24% to 57%) and blue/gray skin discoloration (1% to 7%). Rarely, cases of toxic epidermal necrolysis, exfoliative dermatitis, reversible alopecia, bullous dermatosis, linear IgA disease, cutaneous vasculitis, and pustular psoriasis have been reported. Exfoliative dermatitis, toxic epidermal necrolysis, skin cancer, and pruritus have been reported in postmarketing experience. Additional postmarketing reports have included urticaria and eczema.[Ref]

A retrospective study of 44 patients found by univariate analysis that patients who experienced dermatologic side effects were younger than patients who did not (mean age 48 years vs. 60 years, respectively). Patients younger than 60 years were more likely to develop photosensitivity or blue-gray skin discoloration than those 60 years or older.[Ref]

Nervous system

In one study of 102 patients treated for a mean duration of nine months, 45 (44%) developed some sort of neurotoxic reaction that required discontinuation of therapy. The most frequent findings were tremor in 44, peripheral neuropathy in 10, and ataxia in 7 patients.[Ref]

Nervous system side effects have been reported the most frequently. These have included tremor (9% to 59%), ataxia (2% to 37%), and peripheral neuropathy (1% to 10%). Dyskinesia, disorientation, confusion, paresthesias, headache, sleep disturbances, impaired memory, ataxia, diplopia, proximal muscle weakness, acute narcotizing myopathy, acute intracranial hypertension, and pseudotumor cerebri have been reported. Pseudotumor cerebri, confusional state, disorientation, and parkinsonian symptoms such as akinesia and bradykinesia (sometimes reversible upon discontinuation of therapy) have been reported in postmarketing experience. Also, there have been spontaneous reports of demyelinating polyneuropathy.[Ref]

Hematologic

Hematologic side effects have been reported rarely. Cases of bone marrow suppression resulting in normocytic, normochromic anemia or thrombocytopenia have been reported. Granuloma formation and neutropenia have been reported. Agranulocytosis, hemolytic anemia, aplastic anemia, pancytopenia, neutropenia, thrombocytopenia, and granuloma have been reported in postmarketing experience.[Ref]

A 45-year-old male with Wolff-Parkinson-White syndrome developed diffuse petechiae and ecchymoses associated with thrombocytopenia two weeks after beginning amiodarone. The patient's lymphocytes showed a high stimulation index using amiodarone, but not with other antiarrhythmic agents, such as quinidine. The platelet count returned to normal after amiodarone was stopped and prednisone was given. Rechallenge two months later resulted in recurrent thrombocytopenia.

A 63-year-old male with atrial fibrillation developed bone marrow granulomas after 17 months of treatment with amiodarone. The patient's course was suggestive of amiodarone-induced granulomas, although a definitive cause was not determined.

A 71-year-old male with a history of chronic lymphatic leukemia underwent amiodarone therapy after developing atrial fibrillation. Four weeks after amiodarone therapy was initiated, the patient developed neutropenia which later resolved seven days after discontinuation.[Ref]

Renal

In a series of 30 consecutive patients started on amiodarone and followed for 12 months, 28 (93%) developed a mean increase in the serum creatinine of 11%. Two patients were excluded from analysis. One had previous exposure to amiodarone, which was consider a confounding variable, and one had severe congestive heart failure, which was considered the probable cause of decreased renal function in that case. No patient had renal insufficiency that warranted discontinuation of therapy. Amiodarone may alter creatinine renal tubular secretion or creatinine release by muscle. It is not known whether amiodarone affects the vascular tone of the afferent or efferent arterioles of the renal glomeruli.[Ref]

Renal side effects including renal insufficiency, acute renal failure, and renal impairment have been reported in postmarketing experience.[Ref]

Psychiatric

Psychiatric side effects including altered mental status, hallucinations, and delirium have been reported in postmarketing experience.[Ref]

A 66-year-old male with refractory ventricular tachycardia developed psychotic delusions 17 days after beginning amiodarone therapy. The delirium persisted after the addition of benzodiazepines and when all drugs except amiodarone were discontinued. Delusions resolved one week after amiodarone was stopped. The patient subsequently did well after substitution with flecainide.[Ref]

Genitourinary

Genitourinary side effects have been reported rarely. These have included noninfectious epididymitis, testicular dysfunction, and male impotence. Epididymitis and impotence have been reported in postmarketing experience.[Ref]

A significant correlation between the development of epididymitis and prolonged therapy with high dose amiodarone has been noted in the urological literature. In one series of 56 men who were treated with amiodarone, an atypical epididymitis syndrome developed in 6, of whom 5 had bilateral scrotal swelling. The mean daily dose was 700 mg and the mean duration of amiodarone therapy at the time of presentation ranged from 7 to 15 months.[Ref]

Metabolic

Metabolic side effects have included increased total serum cholesterol and triglycerides, decreased glucose tolerance, and increased or decreased thyroid hormone secretion.[Ref]

Local

Local side effects have included thrombophlebitis.[Ref]

Oncologic

Oncologic side effects have included basal cell carcinoma.[Ref]

Musculoskeletal

Musculoskeletal side effects including myopathy, muscle weakness, and rhabdomyolysis have been reported in postmarketing experience.

General

Generally, checking amiodarone blood levels has limited clinical usefulness since there is wide interpatient variability in the blood amiodarone level and toxicity profile. Side effects occurred more frequently with prolonged administration (greater than 6 months) and appeared to be related to the total cumulative dose. Although as many as 80% of patients have had some side effects, discontinuation of therapy because of serious or disturbing toxicity has occurred in only 10% to 15% of patients.[Ref]

References

1. Harris L, McKenna WJ, Rowland E, Krikler DM "Side effects and possible contraindications of amiodarone use." Am Heart J 106 (1983): 916-23

2. Chuang CL, Chern MS, Chang SC "Amiodarone toxicity in a patient with simultaneous involvement of cornea, thyroid gland, and lung." Am J Med Sci 320 (2000): 64-8

3. Feiner LA, Younge BR, Kazmier FJ, Stricker BH, Fraunfelder FT "Optic neuropathy and amiodarone therapy." Mayo Clin Proc 62 (1987): 702-17

4. Thystrup JD, Fledelius HC "Retinal maculopathy possibly associated with amiodarone medication." Acta Ophthalmol (Copenh) 72 (1994): 639-41

5. Sundelin K, Norrsell K "Enlargement of extraocular muscles during treatment with amiodarone." Acta Ophthalmol Scand 75 (1997): 333-4

6. Reifler DM, Verdier DD, Davy CL, Mostow ND, Wendt VE "Multiple chalazia and rosacea in a patient treated with amiodarone." Am J Ophthalmol 103 (1987): 594-5

7. Macaluso DC, Shults WT, Fraunfelder FT "Features of amiodarone-induced optic neuropathy." Am J Ophthalmol 127 (1999): 610-2

8. Weinberg BA, Miles WM, Klein LS, et al. "Five-year follow-up of 589 patients treated with amiodarone." Am Heart J 125 (1993): 109-20

9. Smith WM, Lubbe WF, Whitlock RM, Mercer J, Rutherford JD, Roche AH "Long-term tolerance of amiodarone treatment for cardiac arrhythmias." Am J Cardiol 57 (1986): 1288-93

10. Purvin V, Kawasaki A, Borruat FX "Optic neuropathy in patients using amiodarone." Arch Ophthalmol 124 (2006): 696-701

11. Imgram DV, Jaggarao NS, Chamberlain DA "Ocular changes resulting from therapy with amiodarone." Br J Ophthalmol 66 (1982): 676-9

12. Raeder EA, Podrid PJ, Lown B "Side effects and complications of amiodarone therapy." Am Heart J 109 (1985): 975-83

13. SeemongalDass RR, Spencer SR "Bilateral optic neuropathy linked with amiodarone." Eye 12 (1998): 474-7

14. Santaella RM, Fraunfelder FW "Ocular adverse effects associated with systemic medications : recognition and management." Drugs 67 (2007): 75-93

15. Morady F, Sauve MJ, Malone P, et al "Long-term efficacy and toxicity of high-dose amiodarone therapy for ventricular tachycardia or ventricular fibrillation." Am J Cardiol 52 (1983): 975-9

16. Jafari-Fesharaki M, Scheinman MM "Adverse effects of amiodarone." Pacing Clin Electrophysiol 21 (1998): 108-20

17. Peter T, Hamer A, Mandel WJ, Weiss D "Evaluation of amiodarone therapy in the treatment of drug-resistant cardiac arrhythmias: long-term follow-up." Am Heart J 106 (1983): 943-50

18. Mindel JS, Anderson J, Johnson G, et al. "Absence of bilateral vision loss from amiodarone: a randomized trial." Am Heart J 153 (2007): 837-42

19. MacNeil DJ "The side effect profile of class III antiarrhythmic drugs: focus on d,l-sotalol." Am J Cardiol 80 (1997): g90-8

20. Harris L, McKenna WJ, Rowland E, Holt DW, Storey GC, Krikler DM "Side effects of long-term amiodarone therapy." Circulation 67 (1983): 45-51

21. Banerjee S, James CB "Amiodarone and dysthyroid eye disease." Br J Ophthalmol 80 (1996): 851-2

22. Naccarelli GV, Rinkenberger RL, Dougherty AH, Giebel RA "Amiodarone: pharmacology and antiarrhythmic and adverse effects." Pharmacotherapy 5 (1985): 298-313

23. Bauman JL, Berk SI, Hariman RJ et al "Amiodarone for sustained ventricular tachycardia: efficacy, safety, and factors influencing long-term outcome." Am Heart J 114 (1987): 1436-44

24. Podrid PJ "Amiodarone: reevaluation of an old drug." Ann Intern Med 122 (1995): 689-700

25. Faggiano P, Gardini A, Daloia A, Benedini G, Giordano A "Torsade de pointes occurring early during oral amiodarone treatment." Int J Cardiol 55 (1996): 205-8

26. Kreiss Y, Sidi Y, Gur H "Efficacy and safety of intravenous amiodarone in recent-onset atrial fibrillation: experience in patients admitted to a general internal medicine department." Postgrad Med J 75 (1999): 278-81

27. Kowey PR, Marinchak RA, Rials SJ, Filart RA "Intravenous amiodarone." J Am Coll Cardiol 29 (1997): 1190-8

28. Dimopoulou I, Marathias K, Daganou M, Prapas S, Stavridis G, Khoury M, Geroulanos S, Cokkinos DV "Low-dose amiodarone-related complications after cardiac operations." J Thorac Cardiovasc Surg 114 (1997): 31-7

29. Vorperian VR, Havighurst TC, Miller S, January CT "Adverse effects of low dose amiodarone: a meta-analysis" J Am Coll Cardiol 30 (1997): 791-8

30. Sclarovsky S, Lewin RF, Kracoff O, Strasberg B, Arditti A, Agmon J "Amiodarone-induced polymorphous ventricular tachycardia." Am Heart J 105 (1983): 6-12

31. Myers M, Peter T, Weiss D "Benefit and risks of long-term amiodarone therapy for sustained ventricular tachycardia/fibrillation: minimum of three-year follow-up in 145 patients." Am Heart J 119 (1990): 8-14

32. Tahapary GJM, Suttorp MJ "Oral amiodarone and atrial fibrillation." Lancet 358 (2001): 147

33. Faggiano P, Gardini A, D'Aloia A, Benedini G, Giordano A "Torsade de pointes occurring early during oral amiodarone treatment" Int J Cardiol 55 (1996): 205-8

34. Fogoros RN, Anderson KP, Winkle RA, Swerdlow CD, Mason JW "Amiodarone: clinical efficacy and toxicity in 96 patients with recurrent, drug-refractory arrhythmias." Circulation 68 (1983): 88-94

35. Williamson BD, Hummel J, Niebauer M, Man C, Strickberger SA, Daoud E, Morady F "Bradycardia-facilitated polymorphic ventricular tachycardia caused by amiodarone after radiofrequency modification of atrioventricular conduction." Am Heart J 130 (1995): 399-401

36. Kreeger RW, Hammill SC "New antiarrhythmic drugs: tocainide, mexiletine, flecainide, encainide, and amiodarone." Mayo Clin Proc 62 (1987): 1033-50

37. Bardaji A, Vidal F, Richart C "T wave alternans associated with amiodarone." J Electrocardiol 26 (1993): 155-7

38. Keren A, Tzivoni D, Gottlieb S, Benhorin J, Stern S "Atypical ventricular tachycardia (torsade de pointes) induced by quinidine and disopyramide." Chest 81 (1982): 384-6

39. Veltri EP, Reid PR "Sinus arrest with intravenous amiodarone." Am J Cardiol 58 (1986): 1110-1

40. Fogoros RN "Amiodarone-induced refractoriness to cardioversion." Ann Intern Med 100 (1984): 699-700

41. Gottlieb SS, Riggio DW, Lauria S, Peters RW, Shorofsky SR, Cines M, Froman D, Gold MR "High dose oral amiodarone loading exerts important hemodynamic actions in patients with congestive heart failure." J Am Coll Cardiol 23 (1994): 560-4

42. "Product Information. Cordarone Intravenous (amiodarone)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

43. Hohnloser SH, Klingenheben T, Singh BN "Amiodarone-associated proarrhythmic effects - a review with special reference to torsade de pointes tachycardia." Ann Intern Med 121 (1994): 529-35

44. Boriani G, Biffi M, Frabetti L, Azzolini U, Sabbatani P, Bronzetti G, Capucci A, Magnani B "Ventricular fibrillation after intravenous amiodarone in wolff-parkinson-white syndrome with atrial fibrillation." Am Heart J 131 (1996): 1214-6

45. Aravanis C "Acute thrombophlebitis due to IV use of amiodarone." Chest 82 (1982): 515-6

46. Mason JW "Amiodarone." N Engl J Med 316 (1987): 455-66

47. Cybulski J, Kulakowski P, Makowska E, Czepiel A, Sikorafrac M, Ceremuzynski L "Intravenous amiodarone is safe and seems to be effective in termination of paroxysmal supraventricular tachyarrhythmias." Clin Cardiol 19 (1996): 563-6

48. Sheikhzadeh A, Schafer U, Schnabel A "Drug-induced lupus erythematosus by amiodarone." Arch Intern Med 162 (2002): 834-6

49. Kerin NZ, Aragon E, Faitel K, Frumin H, Rubenfire M "Long-term efficacy and toxicity of high- and low-dose amiodarone regimens." J Clin Pharmacol 29 (1989): 418-23

50. Singh SN, Fletcher RD, Fisher SG, et al. "Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia." N Engl J Med 333 (1995): 77-82

51. Ammar A, Wong M, Singh BN "Divergent effects of chronic amiodarone administration on systolic and diastolic function in patients with heart disease." Am J Cardiol 75 (1995): 465-9

52. Mooss AN, Mohiuddin SM, Hee TT, et al "Efficacy and tolerance of high-dose intravenous amiodarone for recurrent, refractory ventricular tachycardia." Am J Cardiol 65 (1990): 609-14

53. Blanc JJ, Voinov C, Maarek M "Comparison of oral loading dose of propafenone and amiodarone for converting recent-onset atrial fibrillation." Am J Cardiol 84 (1999): 1029-32

54. Haffajee CI, Love JC, Canada AT, Lesko LJ, Asdourian G, Alpert JS "Clinical pharmacokinetics and efficacy of amiodarone for refractory tachyarrhythmias." Circulation 67 (1983): 1347-55

55. Wilson JS, Podrid PJ "Side effects from amiodarone." Am Heart J 121 (1991): 158-71

56. Garguichevich JJ, Ramos JL, Gambarte A, Gentile A, Hauad S, Scapin O, Sirena J, Tibaldi M, Toplikar J "Effect of amiodarone therapy on mortality in patients with left ventricular dysfunction and asymptomatic complex ventricular arrhythmias: argentine pilot study of sudden death and amiodarone (EPAMSA)." Am Heart J 130 (1995): 494-500

57. Peuhkurinen K, Niemela M, Ylitalo A, Linnaluoto M, Lilja M, Juvonen J "Effectiveness of amiodarone as a single oral dose for recent-onset atrial fibrillation." Am J Cardiol 85 (2000): 462-5

58. Patel AA, White CM, Gillespie EL, Kluger J, Coleman CI "Safety of amiodarone in the prevention of postoperative atrial fibrillation: A meta-analysis." Am J Health Syst Pharm 63 (2006): 829-37

59. Gill J, Heel RC, Fitton A "Amiodarone: an overview of its pharmacological properties, and review of its therapeutic use in cardiac arrhythmias." Drugs 43 (1992): 69-110

60. Burland RJ, Millard FJ "Fibrosing alveolitis associated with amiodarone." Eur J Respir Dis 65 (1984): 616-9

61. Ott MC, Khoor A, Leventhal JP, Paterick TE, Burger CD "Pulmonary toxicity in patients receiving low-dose amiodarone." Chest 123 (2003): 646-51

62. Reasor MJ, Kacew S "An evaluation of possible mechanisms underlying amiodarone-induced pulmonary toxicity." Proc Soc Exp Biol Med 212 (1996): 297-304

63. Piccione W Jr, Faber LP, Rosenberg MS "Amiodarone-induced pulmonary mass." Ann Thorac Surg 47 (1989): 918-9

64. Greenspon AJ, Kidwell GA, Hurley W, Mannion J "Amiodarone-related postoperative adult respiratory distress syndrome." Circulation 84 (1991): 407-15

65. Carmichael LC, Newman JH "Lymphocytic pleural exudate in a patient receiving amiodarone." Br J Clin Pract 50 (1996): 228-30

66. Donaldson L, Grant IS, Naysmith MR, Thomas JSJ "Acute amiodarone-induced lung toxicity." Intensive Care Med 24 (1998): 626-30

67. Yavuzgil O, Goksel T, Gurgun C, Hasdemir C "New-onset bronchial asthma induced by low-dose amiodarone." Ann Pharmacother 39 (2005): 385-6

68. Vizioli LD, Cho SH "Amiodarone-associated hemoptysis." Chest 105 (1994): 305-6

69. Valle JM, Alvarez D, Antunez J, Valdes L "Bronchiolitis obliterans organizing pneumonia secondary to amiodarone: a rare aetiology." Eur Respir J 8 (1995): 470-1

70. Jessurun GAJ, Crijns HJGM "Amiodarone pulmonary toxicity - dose and duration of treatment are not the only determinants of toxicity." BMJ 314 (1997): 619-20

71. Cendrasekhar A, Barke RA, Druck P "Recurrent amiodarone pulmonary toxicity." South Med J 89 (1996): 85-6

72. Polkey MI, Wilson POG, Rees PJ "Amiodarone pneumonitis: no safe dose." Respir Med 89 (1995): 233-5

73. Chendrasekhar A, Barke RA, Druck P "Recurrent amiodarone pulmonary toxicity." South Med J 89 (1996): 85-6

74. Kirkali Z "Re: Recurrent bilateral amiodarone induced epididymitis." J Urol 162 (1999): 808-9

75. Akoun GM, Cadranel JL, Blanchette G, Milleron BJ, Mayaud CM "Bronchoalveolar lavage cell data in amioidarone-associated pneumonitis: evaluation in 22 patients." Chest 99 (1991): 1177-82

76. Jessurun GAJ, Hoogenberg K, Crijns HJGM "Bronchiolitis obliterans organizing pneumonia during low-dose amiodarone therapy." Clin Cardiol 20 (1997): 300-2

77. Pollak PT, Sharma AD, Carruthers SG "Relation of amiodarone hepatic and pulmonary toxicity to serum drug concentrations and superoxide dismutase activity." Am J Cardiol 65 (1990): 1185-91

78. Satz AK, Stoelting RK, Gibbs PS "Intraoperative pulmonary edema in a patient being treated with amiodarone." Anesth Analg 73 (1991): 821-3

79. Singh SN, Fisher SG, Deedwania PC, Rohatgi P, Singh BN, Fletcher RD "Pulmonary effect of amiodarone in patients with heart failure. The Congestive Heart Failure-Survival Trial of Antiarrhythmic Therap (CHF-STAT) Investigators (Veterans Affairs Cooperative Study No 320)." J Am Coll Cardiol 30 (1997): 514-7

80. Pollak PT, Sami M "Acute necrotizing pneumonitis and hyperglycemia after amiodarone therapy." Am J Med 76 (1984): 935-9

81. Endoh Y, Hanai R, Uto K, Uno M, Nagashima H, Narimatsu A, Takizawa T, Onishi S, Kasanuki H "KL-6 as a potential new marker for amiodarone-induced pulmonary toxicity." Am J Cardiol 86 (2000): 229-31

82. Jessurun GA, Hoogenberg K, Crijns HJ "Bronchiolitis obliterans organizing pneumonia during low-dose amiodarone therapy." Clin Cardiol 20 (1997): 300-2

83. Tidwell BH, Jones JS "Amiodarone-induced pulmonary hypersensitivity." Ann Pharmacother 31 (1997): 1541

84. Oren S, Turkot S, Golzman B, London D, Ben-Dor D, Weiler Z "Amiodarone-induced bronchiolitis obliterans organizing pneumonia (BOOP)." Respir Med 90 (1996): 167-9

85. Wilson BD, Lippmann ML "Susceptibility to amiodarone-induced pulmonary toxicity: relationship to the uptake of amiodarone by isolated lung cells." Lung 174 (1996): 31-41

86. Hargreaves MR, Benson MK "Amiodarone pneumonitis: no safe dose." Respir Med 90 (1996): 119

87. Manolis AS, Tordjman T, Mack KD, Estes NA III "Atypical pulmonary and neurologic complications of amiodarone in the same patient." Arch Intern Med 147 (1987): 1805-9

88. Fraire AE, Guntupalli KK, Greenberg SD, Cartwright J, Jr Chasen MH "Amiodarone pulmonary toxicity: a multidisciplinary review of current status." South Med J 86 (1993): 67-77

89. Scharf C, Oechslin EN, Salomon F, Kiowski W "Clinical picture: Amiodarone-induced pulmonary mass and cutaneous vasculitis." Lancet 358 (2001): 2045

90. Malden ES, Tartar VM, Gutierrez FR "Acute fatality following pulmonary angiography in a patient on an amiodarone regimen--a case report." Angiology 44 (1993): 152-5

91. Morrow B, Shorten GD, Sylvester W "Postoperative amiodarone pulmonary toxicity." Anaesth Intensive Care 21 (1993): 361-2

92. Ravishankar R, Samuels LE, Kaufman MS, et al "Amiodarone-associated hemoptysis." Am J Med Sci 316 (1998): 390-2

93. Brinker A, Johnston M "Acute pulmonary injury in association with amiodarone." Chest 125 (2004): 1591-2

94. Liverani E, Armuzzi A, Mormile F, Anti M, Gasbarrini G, Gentiloni N "Amiodarone-induced adult respiratory distress syndrome after nonthoracotomy subcutaneous defibrillator implantation." J Intern Med 249 (2001): 565-6

95. Oren S, Turkot S, Golzman B, London D, Bendor D, Weiler Z "Amiodarone-induced bronchiolitis obliterans organizing pneumonia (BOOP)." Respir Med 90 (1996): 167-9

96. Rakita L, Sobol SM, Mostow N, Vrobel T "Amiodarone pulmonary toxicity." Am Heart J 106 (1983): 906-16

97. Tisdale JE, Follin SL, Ordelova A, Webb CR "Risk factors for the development of specific noncardiovascular adverse effects associated with amiodarone." J Clin Pharmacol 35 (1995): 351-6

98. Adams GD, Kehoe R, Lesch M, Glassroth J "Amiodarone-induced pneumonitis: assessment of risk factors and possible risk reduction." Chest 93 (1988): 254-63

99. Vanmieghem W, Coolen L, Malysse I, Lacquet LM, Demedts MGP "Amiodarone and the development of ARDS after lung surgery." Chest 105 (1994): 1642-5

100. Kharabsheh S, Abendroth CS, Kozak M "Fatal pulmonary toxicity occurring within two weeks of initiation of amiodarone." Am J Cardiol 89 (2002): 896-8

101. Olshanssky B "Amiodarone-induced pulmonary toxicity." N Engl J Med 337 (1997): 1814

102. Akoun GM, Milleron BJ, Badaro DM, Mayard CM, Liote HA "Pleural T-lymphocyte subsets in amiodarone-associated pleuropneumonitis." Chest 95 (1989): 596-7

103. Kudenchuk PJ, Pierson DJ, Greene HL, Graham EL, Sears GK, Trobaugh GB "Prospective evaluation of amiodarone pulmonary toxicity." Chest 86 (1984): 541-8

104. Podrid PJ "Amiodarone: reevaluation of an old drug." Ann Intern Med 122 (1995): 689-700

105. Khanderia U, Jaffe CA, Theisen V "Amiodarone-induced thyroid dysfunction." Clin Pharm 12 (1993): 774-9

106. Harjai KJ, Licata AA "Amiodarone induced hyperthyroidism: a case series and brief review of literature." Pacing Clin Electrophysiol 19 (1996): 1548-54

107. Mehra A, Widerhorn J, Lopresti J, Rahimtoola SH "Amiodarone-induced hyperthyroidism: thyroidectomy under local anesthesia." Am Heart J 122 (1991): 1160-1

108. Martino E, Aghinilombardi F, Bartalena L, Grasso L, Loviselli A, Velluzzi F, Pinchera A, Braverman LE "Enhanced susceptibility to amiodarone-induced hypothyroidism in patients with thyroid autoimmune disease." Arch Intern Med 154 (1994): 2722-6

109. Loh KC "Amiodarone-induced thyroid disorders: a clinical review." Postgrad Med J 76 (2000): 133-40

110. Politi A, Poggio G, Margiotta A "Can amiodarone induce hyperglycaemia and hypertriglyceridaemia?" Br Med J 288 (1984): 285

111. Figge J, Dluhy RG "Amiodarone-induced elevation of thyroid stimulating hormone in patients receiving levothyroxine for primary hypothyroidism." Ann Intern Med 113 (1990): 553-5

112. Conen D, Melly L, Kaufmann C, et al. "Amiodarone-induced thyrotoxicosis: clinical course and predictors of outcome." J Am Coll Cardiol 49 (2007): 2350-5

113. Bindra A, Braunstein GD "Thyroiditis." Am Fam Physician 73 (2006): 1769-76

114. Batcher EL, Tang XC, Singh BN, Singh SN, Reda DJ, Hershman JM "Thyroid function abnormalities during amiodarone therapy for persistent atrial fibrillation." Am J Med 120 (2007): 880-5

115. Ybarra J, Fuster D, Martin F, Lomena F, Torregrossa JV "Clinical picture: Amiodarone-induced thyroiditis." Lancet 359 (2002): 69

116. Enia G, Costante G, Catalano C, Zoccali C, Maggiore Q "Severe hypothyroidism induced by amiodarone in a dialysis patient." Nephron 46 (1987): 206-7

117. Ahmad S "Amiodarone and sexual dysfunction." Am Heart J 130 (1995): 1320-1

118. Harjai KJ, Licata AA "Effects of amiodarone on thyroid function." Ann Intern Med 126 (1997): 63-73

119. Iervasi G, Clerico A, Bonini R, Manfredi C, Berti S, Ravani M, Palmieri C, Carpi A, Biagini A, Chopra IJ "Acute effects of amiodarone administration on thyroid function in patients with cardiac arrhythmia." J Clin Endocrinol Metab 82 (1997): 275-80

120. Roti E, Minelli R, Gardini E, Bianconi L, Braverman LE "Thyrotoxicosis followed by hypothyroidism in patients treated with amiodarone. A possible consequence of a destructive process in the thyroid." Arch Intern Med 153 (1993): 886-92

121. Mulligan DC, Mchenry CR, Kinney W, Esselstyn CB, Numann PJ, Roher H, Albertson D "Amiodarone-induced thyrotoxicosis: clinical presentation and expanded indications for thyroidectomy." Surgery 114 (1993): 1114-9

122. Samaras K, Marel GM "Failure of plasmapheresis, corticosteroids and thionamides to ameliorate a case of protracted amiodarone-induced thyroiditis." Clin Endocrinol (Oxf) 45 (1996): 365-8

123. Sinha MK, Kuriakose B, Aggarwal RK "Amiodarone induced hyperthyroidism." Postgrad Med J 77 (2001): 358

124. Benbassat CA, MechlisFrish S, Cohen M, Blum I "Amiodarone-induced thyrotoxicosis type 2: A case report and review of the literature." Am J Med Sci 320 (2000): 288-91

125. Goichot B, Grunenberger F, Schlienger JL "Amiodarone-induced thyroiditis." Lancet 359 (2002): 2275-6

126. Mariotti S, Loviselli A, Murenu S, et al "High prevalence of thyroid dysfunction in adult patients with beta-thalassemia major submitted to amiodarone treatment." J Endocrinol Invest 22 (1999): 55-63

127. Dobs AS, Sarma PS, Guarnieri T, Griffith L "Testicular dysfunction with amiodarone use." J Am Coll Cardiol 18 (1991): 1328-32

128. Lakhdar AA, Farish E, Hillis WS, Dunn FG "Long-term amiodarone therapy raises serum cholesterol." Eur J Clin Pharmacol 40 (1991): 477-80

129. Harjai KJ, Licata AA "Amiodarone induced hyperthyroidism: a case series and brief review of literature." Pacing Clin Electrophysiol 19 (1996): 1548-54

130. Hauptman PJ, Fyfe B, Mechanick J, Lansman S, Gass A "Fatal hyperthyroidism after amiodarone treatment and total lymphoid irradiation in a heart transplant recipient [published erratum appears in J Heart Lung Transplant 1993 Jul-Aug;12(4):572]." J Heart Lung Transplant 12 (1993): 513-6

131. Singh BN, Nademanee K "Amiodarone and thyroid function: clinical implications during antiarrhythmic therapy." Am Heart J 106 (1983): 857-69

132. Shukla R, Jowett NI, Thompson DR, Pohl JE "Side effects with amiodarone therapy." Postgrad Med J 70 (1994): 492-8

133. Osman F, Franklyn JA, Sheppard MC, Gammage MD "Successful treatment of amiodarone-induced thyrotoxicosis." Circulation 105 (2002): 1275-7

134. Figge HL, Figge J "The effects of amiodarone on thyroid hormone function: a review of the physiology and clinical manifestations." J Clin Pharmacol 30 (1990): 588-95

135. Laroia ST, Zaw KM, Ganti AK, Newman W, Akinwande AO "Amiodarone-induced thyrotoxicosis presenting as hypokalemic periodic paralysis." South Med J 95 (2002): 1326-8

136. Unger J, Lambert M, Jonckheer MH, Denayer P "Amiodarone and the thyroid: pharmacological, toxic and therapeutic effects." J Intern Med 233 (1993): 435-43

137. Ahmad S "Reevaluation of amiodarone." Ann Intern Med 123 (1995): 809

138. Goichot B, Grunenberger F, Schlienger JL "Amiodarone-induced hyperthyroidism." Arch Intern Med 161 (2001): 295

139. Mazonson PD, Williams ML, Cantley LK, Dalldorf FG, Utiger RD, Foster JR "Myxedema coma during long-term amiodarone therapy." Am J Med 77 (1984): 751-4

140. Staubli M, Bircher J, Galeazzi RL, Remund H, Studer H "Serum concentrations of amiodarone during long term therapy: relation to dose, efficacy and toxicity." Eur J Clin Pharmacol 24 (1983): 485-94

141. Beuers U, Heuck A "Iodine accumulation in the liver during long-term treatment with amiodarone." J Hepatol 26 (1997): 439

142. Tavackoli S, Stouffer GA, Sheahan RG "Amiodarone-induced thyrotoxicosis." Am J Med Sci 314 (1997): 97-100

143. Pollak PT, Sharma AD, Carruthers SG "Elevation of serum total cholesterol and triglyceride levels during amiodarone therapy." Am J Cardiol 62 (1988): 562-5

144. Findlay "Amiodarone induced hyperthyroidism." Postgrad Med J 77 (2001): 358

145. Ahmed Z, Goldman JM "Reevaluation of amiodarone." Ann Intern Med 123 (1995): 809

146. Porsche R, Brenner ZR "Amiodarone-induced thyroid dysfunction." Crit Care Nurse 26 (2006): 34-41; quiz 42

147. Daniels GH "Clinical review 120 - Amiodarone-induced thyrotoxicosis." J Clin Endocrinol Metab 86 (2001): 3-8

148. Tieleman RG, Gosselink ATM, Crijns HJGM, Vangelder IC, Vandenberg MP, Dekam PJ, Vangilst WH, Lie KI "Efficacy, safety, and determinants of conversion of atrial fibrillation and flutter with oral amiodarone." Am J Cardiol 79 (1997): 53-7

149. Lwakatare JM, Morris-Jones S, Knight EJ "Fatal fulminating liver failure possibly related to amiodarone treatment." Br J Hosp Med 44 (1990): 60-1

150. Bosch X, Bernadich O "Acute pancreatitis during treatment with amiodarone." Lancet 350 (1997): 1300

151. Sastri SV, Diaz-Arias AA, Marshall JB "Can pancreatitis be associated with amiodarone hepatotoxicity?" J Clin Gastroenterol 12 (1991): 70-3

152. Patel GP, Kasiar JB "Syndrome of inappropriate antidiuretic hormone-induced hyponatremia associated with amiodarone." Pharmacotherapy 22 (2002): 649-51

153. Zehender M "Amiodarone phototoxic reaction." Circulation 92 (1995): 1665

154. Moots RJ, Banerjee A "Exfoliate dermatitis after amiodarone treatment." Br Med J 296 (1988): 1332-3

155. Stafford L "Hypersensitivity reaction to amiodarone in a patient with a previous reaction to an iodinated radiocontrast agent." Ann Pharmacother 41 (2007): 1310-4

156. Mulrow JP, Mulrow CD, McKenna WJ "Pyridoxine and amiodarone-induced photosensitivity." Ann Intern Med 103 (1985): 68-9

157. Monk B "Amiodarone-induced photosensitivity and basal-cell carcinoma." Clin Exp Dermatol 15 (1990): 319-20

158. Breuer HWM, Bossek W, Haferland C, Schmidt M, Neumann H, Gruszka J "Amiodarone-induced severe hepatitis mediated by immunological mechanisms." Int J Clin Pharmacol Ther 36 (1998): 350-2

159. Dootson G, Byatt C "Amiodarone-induced vasculitis and a review of the cutaneous side-effects of amiodarone." Clin Exp Dermatol 19 (1994): 422-4

160. Staubli M, Zimmermann Z, Bircher J "Amiodarone-induced vasculitis and polyserositis." Postgrad Med J 61 (1985): 245-7

161. Primka EJ, Liranzo MO, Bergfeld WF, Dijkstra JW "Amiodarone-induced linear IgA disease." J Am Acad Dermatol 31 (1994): 809-11

162. Pollak PT, You YD "Monitoring of hepatic function during amiodarone therapy." Am J Cardiol 91 (2003): 613-6

163. Puli SR, Fraley MA, Puli V, Kuperman AB, Alpert MA "Hepatic Cirrhosis Caused by Low-Dose Oral Amiodarone Therapy." Am J Med Sci 330 (2005): 257-261

164. Lim PK, Trewby PN, Storey GC, Holt DW "Neuropathy and fatal hepatitis in a patient receiving amiodarone." Br Med J 288 (1984): 1638-9

165. Chang CC, Petrelli M, Tomashefski JF, McCullough AJ "Severe intrahepatic cholestasis caused by amiodarone toxicity after withdrawal of the drug: a case report and review of the literature." Arch Pathol Lab Med 123 (1999): 251-6

166. Kum LC, Chan WW, Hui HH, et al. "Prevalence of amiodarone-related hepatotoxicity in 720 Chinese patients with or without baseline liver dysfunction." Clin Cardiol 29 (2006): 295-9

167. Rhodes A, Eastwood JB, Smith SA "Early acute hepatitis with parenteral amiodarone: a toxic effect of the vehicle?" Gut 34 (1993): 565-6

168. Richer M, Robert S "Fatal hepatotoxicity following oral administration of amiodarone." Ann Pharmacother 29 (1995): 582-6

169. Snir Y, Pick N, Riesenberg K, Yanaiinbar I, Zirkin H, Schlaeffer F "Fatal hepatic failure due to prolonged amiodarone treatment." J Clin Gastroenterol 20 (1995): 265-6

170. Bravo AE, Drewe J, Schlienger RG, Krahenbuhl S, Pargger H, Ummenhofer W "Hepatotoxicity during rapid intravenous loading with amiodarone: Description of three cases and review of the literature." Crit Care Med 33 (2005): 128-134

171. Gregory SA, Webster JB, Chapman GD "Acute hepatitis induced by parenteral amiodarone." Am J Med 113 (2002): 254-5

172. Harrison RF, Elias E "Amiodarone-associated cirrhosis with hepatic and lymph node granulomas." Histopathology 22 (1993): 80-2

173. Morse RM, Valenzuela GA, Greenwald TP, Eulie PJ, Wesley RC, McCallum RW "Amiodarone-induced liver toxicity." Ann Intern Med 109 (1988): 838-41

174. Muir AD, Wilson M "Amiodarone and psoriasis." N Z Med J 95 (1982): 711

175. Bachot N, Wechsler J, Demoule A, Roujeau JC "Amiodarone-related linear IgA bullous dermatosis." J Am Acad Dermatol 49 (2003): E2

176. Gutierrez R, Delpozo J, Carrion C, Delucas R, Garcia B, Casado M, Jimenez E "Vasculitis associated with amiodarone treatment." Ann Pharmacother 28 (1994): 537

177. Ahmad S "Amiodarone and reversible alopecia." Arch Intern Med 155 (1995): 1106

178. Sivaram CA, Beckman KJ "Amiodarone-induced skin discoloration." N Engl J Med 337 (1997): 1813

179. Monk BE "Basal cell carcinoma following amiodarone therapy." Br J Dermatol 133 (1995): 148-9

180. Heger JJ, Prystowsky EN, Zipes DP "Relationships between amiodarone dosage, drug concentrations, and adverse side effects." Am Heart J 106 (1983): 931-5

181. Rogers KC, Wolfe DA "Amiodarone-induced blue-gray syndrome." Ann Pharmacother 34 (2000): 1075

182. Sun DK, Reiner D, Frishman W, Grossman M, Luftschein S "Adverse dermatologic reactions from antiarrhythmic drug therapy." J Clin Pharmacol 34 (1994): 953-66

183. Krauser DG, Segal AZ, Kligfield P "Severe ataxia caused by amiodarone." Am J Cardiol 96 (2005): 1463-4

184. Katrak PH "Stroke patients: do they have a predilection for extrapyramidal side effects from amiodarone?" Arch Phys Med Rehabil 80 (1999): 112-4

185. Roth RF, Itabashi H, Louie J, Anderson T, Narahara KA "Amiodarone toxicity: myopathy and neuropathy." Am Heart J 119 (1990): 1223-4

186. Pellissier JF, Pouget J, Cros D, De Victor B, Serratrice G, Toga M "Peripheral neuropathy induced by amiodarone chlorhydrate: a clinicopathological study." J Neurol Sci 63 (1984): 251-66

187. Biran I, Steiner I "Coital headaches induced by amiodarone." Neurology 58 (2002): 501-2

188. Malaterre HR, Renou C, Kallee K, Gauthier A "Akinesia and amiodarone therapy." Int J Cardiol 59 (1997): 107-8

189. Ahmad S "Amiodarone and reversible benign intracranial hypertension." Cardiology 87 (1996): 90

190. Arbusow V, Strupp M, Brandt T "Amiodarone-induced severe prolonged head-positional vertigo and vomiting." Neurology 51 (1998): 917

191. Clouston PD, Donnelly PE "Acute necrotising myopathy associated with amiodarone therapy." Aust N Z J Med 19 (1989): 483-5

192. Werner EG, Olanow CW "Parkinsonism and amiodarone therapy." Ann Neurol 25 (1989): 630-2

193. Lopez AC, Lopez AM, Jimenez SF, de Elvira MJ "Acute intracranial hypertension during amiodarone infusion." Crit Care Med 13 (1985): 688-9

194. Barry JJ, Franklin K "Amiodarone-induced delirium." Am J Psychiat 156 (1999): 1119

195. Dotti MT, Federico A "Amiodarone-induced Parkinsonism: a case report and pathogenetic discussion." Mov Disord 10 (1995): 233-4

196. Palakurthy PR, Iyer V, Meckler RJ "Unusual neurotoxicity associated with amiodarone therapy." Arch Intern Med 147 (1987): 881-4

197. Groneberg DA, Barkhuizen A "Neutropenia during treatment with amiodarone." Am J Med 110 (2001): 671

198. Rosenbaum H, Ben-Arie Y, Azzam ZS, Krivoy N "Amiodarone-associated granuloma in bone marrow." Ann Pharmacother 32 (1998): 60-2

199. Yamreudeewong W, McIntyre WW, Sun TJ, Ranelli PL "Bone marrow granulomas possibly associated with amiodarone." Pharmacotherapy 20 (2000): 855-9

200. Weinberger I, Rotenberg Z, Fuchs J, Ben-Sasson E, Agmon J "Amiodarone-induced thrombocytopenia." Arch Intern Med 147 (1987): 735-6

201. Wright AJ, Brackenridge RG "Pulmonary infiltration and bone marrow depression complicating treatment with amiodarone." Br Med J 284 (1982): 1303

202. Jacobs MB "Serum creatinine increase associated with amiodarone therapy." N Y State J Med 87 (1987): 358-9

203. Pollak PT, Sharma AD, Carruthers SG "Creatinine elevation in patients receiving amiodarone correlates with serum amiodarone concentration." Br J Clin Pharmacol 36 (1993): 125-7

204. Trohman RG, Castellanos D, Castellanos A, Kessler KM "Amiodarone-induced delirium." Ann Intern Med 108 (1988): 68-9

205. Gasparich JP, Mason JT, Greene HL, Berger RE, Krieger JN "Amiodarone-associated epididymitis: drug-related epididymitis in the absence of infection." J Urol 133 (1985): 971-2

206. GabalShehab LL, Monga M "Recurrent bilateral amiodarone induced epididymitis." J Urol 161 (1999): 921

207. Ibsen HH, Frandsen F, Brandrup F, Moller M "Epididymitis caused by treatment with amiodarone." Genitourin Med 65 (1989): 257-8

208. Surks MI, Sievert R "Drugs and thyroid function." N Engl J Med 333 (1995): 1688-94

209. Odeh M, Schiff E, Oliven A "Hyponatremia during therapy with amiodarone." Arch Intern Med 159 (1999): 2599-600

210. Pollak PT, Tan MH "Elevation of high-density lipoprotein cholesterol in humans during long-term therapy with amiodarone." Am J Cardiol 83 (1999): 296-300, A7

211. Veloso HH, De Paola AA "Thrombophlebitis: a common complication of amiodarone." Am Fam Physician 70 (2004): 1448

212. Aljitawi O, Shabaneh B, Whitaker J "Bilateral upper extremity thrombophlebitis related to intravenous amiodarone: a case report." South Med J 98 (2005): 814-6

213. Monk B "Amiodarone and basal cell carcinoma, coincidence or association?" Br J Dermatol 151 (2004): 933

214. Hall MA, Annas A, Nyman K, Talme T, Emtestam L "Basalioma after amiodarone therapy-not only in Britain." Br J Dermatol 151 (2004): 932-3

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