Agrylin Side Effects

Generic Name: anagrelide

Note: This document contains side effect information about anagrelide. Some of the dosage forms listed on this page may not apply to the brand name Agrylin.

Some side effects of Agrylin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to anagrelide: oral capsule

Along with its needed effects, anagrelide (the active ingredient contained in Agrylin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking anagrelide:

More common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • body aches or pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • congestion
  • cough
  • difficult or labored breathing
  • dryness or soreness of the throat
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • hoarseness
  • rapid weight gain
  • runny nose
  • shortness of breath
  • tender, swollen glands in the neck
  • tightness in the chest
  • trouble with swallowing
  • voice changes
Less common
  • Anxiety
  • blurred vision
  • burning while urinating
  • chills
  • cold sweats
  • confusion
  • decreased urine output
  • dehydration
  • difficult or painful urination
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • general feeling of discomfort or illness
  • headache
  • irregular breathing
  • joint pain
  • large, flat, blue, or purplish patches in the skin
  • loss of appetite
  • muscle aches and pains
  • nausea or vomiting
  • nervousness
  • noisy breathing
  • pale skin
  • redness of the face, neck, arms, and occasionally, upper chest
  • severe pain or pressure in the chest or the jaw, neck, back, or arms
  • shortness of breath
  • sudden severe headache or weakness
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • trouble sleeping
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • weight gain
Incidence not known
  • Abdominal or stomach pain or tenderness
  • clay colored stools
  • dark urine
  • decreased appetite
  • dry cough
  • general feeling of tiredness or weakness
  • itching
  • rapid breathing
  • skin rash
  • yellow eyes or skin

Some side effects of anagrelide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • back pain
  • belching
  • diarrhea
  • excess air or gas in the stomach or intestines
  • full feeling
  • general feeling of discomfort or illness
  • heartburn
  • hives or welts
  • indigestion
  • lack or loss of strength
  • loss of appetite
  • pain
  • passing gas
  • stomach discomfort, upset, or pain
Less common
  • Burning feeling in the chest or stomach
  • change in vision
  • confusion
  • constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • depression
  • difficulty with moving
  • double vision
  • hair loss or thinning of the hair
  • hearing loss
  • impaired vision
  • increased sensitivity of the skin to sunlight
  • leg cramps
  • loss of memory
  • muscle pain or stiffness
  • nervousness
  • problems with memory
  • redness or other discoloration of the skin
  • seeing double
  • severe sunburn
  • sleepiness or unusual drowsiness
  • stuffy nose
  • swelling or inflammation of the mouth
  • swollen joints

For Healthcare Professionals

Applies to anagrelide: oral capsule

Nervous system

Nervous system side effects have included headache (43%), dizziness (15%), asthenia (23%), paresthesia (6%), depression, somnolence, confusion, insomnia, nervousness, and amnesia.


Cardiovascular side effects have included palpitations, chest pain, tachycardia, arrhythmia, hemorrhage, cardiovascular disease, angina pectoris, heart failure, postural hypotension, thrombosis, vasodilation, migraine, and syncope.

Postmarketing reports: Torsades de pointes and ventricular tachycardia


Gastrointestinal side effects have been reported the most frequently. These have included diarrhea (25.7%), nausea (17.1%), abdominal pain (16.4%), flatulence (10.2%), vomiting (9.7%), anorexia (7.7%), pharyngitis (6.8%), and dyspepsia (5.2%). Constipation, hemorrhage, gastritis, melena, aphthous stomatitis, and eructation have been reported in less than 5%.


General side effects have included edema (20%), pain (15%), fever (8%), peripheral edema (8%), anorexia (7%), malaise (6%), back pain (5%), pruritus (5%), dehydration, tinnitus, flu symptoms, chills, and photosensitivity.


Hematologic side effects including anemia, thrombocytopenia, ecchymosis, and lymphadenopathy have been reported.


Hepatic side effects have included elevated liver enzymes and at least one case of cholestatic liver failure attributed to anagrelide (the active ingredient contained in Agrylin) use.


Musculoskeletal side effects have included arthralgia, myalgia, and leg cramps.


Respiratory side effects have included pharyngitis, cough, rhinitis, epistaxis, respiratory disease, sinusitis, pneumonia, bronchitis, and asthma. Postmarketing reports have included interstitial lung diseases (including allergic alveolitis, eosinophilic pneumonia and interstitial pneumonitis).


Dermatologic side effects have included rash, skin disease, and alopecia.


Ocular side effects have included amblyopia, abnormal vision, visual field abnormality, and diplopia.


Genitourinary side effects have included dysuria and hematuria. Erectile dysfunction has been reported in a young man.

A 30 year old man developed erectile dysfunction after two months of treatment with anagrelide at the initial recommended dosage. Two weeks after anagrelide was stopped, the erectile dysfunction disappeared. The patient's course was suggestive of anagrelide induced erectile dysfunction, although a definitive cause could not be determined.


Hypersensitivity side effects have included severe hypersensitivity pneumonitis. A 60 year old woman developed shortness of breath, palpitations, and chest pain after one week of treatment with anagrelide (the active ingredient contained in Agrylin) leading to respiratory failure and intubation by week five. Patient recovered after empiric treatment with methylprednisolone.

The authors of the case report of severe hypersensitivity pneumonitis suggest that patients receiving anagrelide therapy, alone or in combination with hydroxyurea, may benefit from monitoring with serial chest X-rays, pulmonary function testing, and echocardiography to detect the development of cardiomyopathy or hypersensitivity pneumonitis.


Renal side effects have included postmarketing reports of tubulointerstitial nephritis.

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