Kineret

Generic Name: anakinra (injectable) (an na KIN rah)
Brand Names: Kineret

What is Kineret?

Kineret reduces the actions of chemicals in the body that are involved in inflammatory and immune responses.

Kineret is used to treat the symptoms of moderate to severe rheumatoid arthritis in patients who have had an inadequate response to one or more antirheumatic drugs. Kineret may be used in combination with other antirheumatic medications.

Kineret may also be used for purposes other than those listed in this medication guide.

Important information about Kineret

In rare cases, people receiving Kineret have developed serious infections. Notify your doctor immediately if you develop a fever, flu-like symptoms, or any other sign of infection. Treatment with Kineret should not be started in patients with active infections or those taking other medicines that may suppress the immune system. The use of Kineret in combination with etanercept (Enbrel), infliximab (Remicade), adalimumab (Humira), or other medicines used to treat rheumatoid arthritis, may also increase the risk of a serious infection.

Before using Kineret

In rare cases, people receiving Kineret have developed serious infections. Notify your doctor immediately if you develop a fever, flu-like symptoms, or any other sign of infection. Treatment with Kineret should not be started in patients with active infections or those taking other medicines that may suppress the immune system. The use of Kineret in combination with etanercept (Enbrel), infliximab (Remicade), adalimumab (Humira), or other medicines used to treat rheumatoid arthritis, may also increase the risk of a serious infection. Do not use Kineret without first talking to your doctor if you

• are currently taking etanercept (Enbrel), infliximab (Remicade), or adalimumab (Humira) to treat rheumatoid arthritis;

• have an active infection or a history of recurrent infection;

• have recently been exposed to varicella (chickenpox) virus;

• have a bone marrow disease;

• have a suppressed immune system due to a medical condition or treatment with medication;

• have recently received a live vaccine; or

• have kidney disease.

You may not be able to use Kineret, or you may require a dosage adjustment or special monitoring during treatment.

Kineret is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not use Kineret without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Kineret passes into breast milk. Do not use Kineret without first talking to your doctor if you are breast-feeding a baby. The safety and effectiveness of Kineret have not been established for pediatric patients.

How should I use Kineret?

Use Kineret exactly as directed by your doctor. If you do not understand these directions, ask your doctor, nurse, or pharmacist to explain them to you.

Kineret is used as a subcutaneous (under the skin) injection only. Your doctor or nurse will give you detailed instructions on how and where to inject Kineret. Do not inject this medication if you are unsure how.

Kineret is usually injected once a day. The dose should be injected at approximately the same time every day.

The medication may be allowed to reach room temperature by removing it from the refrigerator about 60 to 90 minutes before administration. This may reduce discomfort during or following the injection.

The medication can be injected into the outer thighs, stomach, back of the upper arms, or buttocks. Rotate the injection site daily to reduce the possibility of soreness or redness. The area of the body being injected does not need to change daily, however each injection site should be at least one inch from the previous day's injection site.

Do not inject Kineret if it is discolored, cloudy, or if it has particles in it. Do not shake the prefilled syringe and do not use Kineret beyond the expiration date shown on the carton. If the solution appears foamy, allow it to sit for a few minutes until it clears.

This medication does not contain a preservative. Therefore, throw away any medication remaining in the syringe after a dose. Do not save the medication for later use.

Never reuse a needle or syringe. Dispose of all needles and syringes in an appropriate, puncture-resistant disposal container.

Your doctor may want you to have blood tests or other medical evaluations during treatment with Kineret to monitor progress and side effects.

Kineret should be used on a regular basis to get the most benefit.

Store Kineret in the refrigerator (36 to 46 degrees Fahrenheit/2 to 8 degrees Celsius) away from moisture, heat and light. Do not allow Kineret to freeze.

What happens if I miss a dose?

Notify your healthcare provider if you miss a dose of this medication.

What happens if I overdose?

Serious or life-threatening side effects are unlikely to occur from an overdose of Kineret. Contact your doctor or seek medical attention if an overdose of Kineret is suspected.

What should I avoid while using Kineret?

Kineret has been associated with an increased incidence of infection. Avoid contact with people who have colds, the flu, or other contagious illnesses [e.g., varicella (chickenpox) and others] and do not receive vaccines that contain live strains of a virus (e.g., live oral polio vaccine) during treatment with Kineret. In addition, avoid contact with individuals who have recently been vaccinated with a live vaccine. There is a chance that the virus can be passed on to you.

Kineret side effects

If you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of your lips, tongue, or face; or hives), stop using Kineret, and seek emergency medical attention. In rare cases, people receiving Kineret have developed serious infections. Notify your doctor immediately if you develop a fever, flu-like symptoms, or any other sign of infection.

Other less serious side effects may be more likely to occur. Continue to use Kineret and notify your doctor if you experience

• nausea or diarrhea;

• a headache;

• sinus irritation or infection; or

• redness, bruising, pain, or swelling at the injection site.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

See also: Kineret side effects (in more detail)

What other drugs will affect Kineret?

Do not receive "live" vaccines during treatment with Kineret without first talking to your doctor. Administration of a live vaccine may result in an inadequate immune response or infection.

Before using Kineret, talk to your doctor if you are taking

• etanercept (Enbrel);

• infliximab (Remicade);

• adalimumab (Humira); or

• a medicine that may decrease the effects of the immune system.

You may not be able to use Kineret, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with Kineret. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

• Your pharmacist has more information about Kineret written for health professionals that you may read.

What does my medication look like?

Anakinra is available with a prescription under the brand name Kineret. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Kineret 100 mg - prefilled glass syringe with 27 gauge needle (0.67 mL)